关键词:  2型糖尿病；糖尿病足；下肢动脉病变；截肢；螺旋CT血管成像

Abstract:

To determine the relationship between angiographic evaluation of peripheral arterial occlusive disease and amputation in diabetic foot. MethodsThere were 95 patients involved in this study. All the patients were divided into two groups after 1 year′s observation according to with or without amputation. The diabetic patients were interviewed about duration, treatment profile, presence or absence of chronic DM complications, prior amputation, blood  pressure, height, and body mass index (BMI). Fasting blood samples were taken to assess lipid profile, blood sugar and glycated hemoglobin (HbA1C) levels, total lipid profile (high density lipoprotein (HDL), low density lipoprotein (LDL)) and urinary albumin concentration. Lower limb arterial diseases were assessed in all the diabetic feet by slice spiral CT angiography(CTA). All the patients underwent CTA examination on the common iliac artery, the external iliac artery, the femoral artery, the popliteal artery, the anterior tibial artery, the posterior tibial artery, the peroneal artery and the dorsal artery of the foot. Diagnosis of diabetic foot accorded with Wagner classification. ResultsAmputation was carried out in 23.2% of the patients afflicted with diabetic foot. Multivariate logistic regression analysis revealed that angiographic score(OR=1.2，P=0.012), complicated Infection(OR=4.2，P=0.027) andPrior amputation(OR=5.8，P=0.017) were independent risk factors for amputation. Conclusion Angiographic score, complicated infection and prior amputation are independent risk factors for amputation.

Key words:  Diabetes; Diabetic foot; Peripheral arterial occlusi ve disease; Amputation; Slice spiral CT angiography