关键词: 2型糖尿病；中膜厚度；动脉粥样斑块

Abstract:

To investigate the incidence of artery plaques in newly  diagnosed type 2 diabetic patients and its correlated risk factors. MethodsBmode ultrasound was used for screening for plaques located in the common carotid artery, common iliac artery or femoral artery. Based on thickness of IMT, patients were divided into two groups: 425 patients without plaques（IMT≤1.3?mm）and 113 patients with artery plaques（IMT＞1.3?mm）. Furthermore, differences of age, sex, waistline, BMI, SBP, DBP, FBG, 2hBG, HbA1c, HOMAIR, TG, TC, LDLC and HDLC between the two groups were calculated and subsequently analyzed. ResultsIncidence of artery plaques in these newly diagnosed type 2 diabetic patients was 28.6%. The IMT thickness of the common carotid artery, common iliac artery or femoral artery in patients without artery plaques was (0.74±0.17)mm, (0.74±0.15)mm or (0.74±0.17)mm. However, in patients with artery plaques, the corresponding data was (0.91±0.23)mm, (0.94±0.21)mm and (0.88±0.22)mm. A significant difference in mean values of intimamedia thickness was observed between patients with artery plaques and the controls（P<0.05）.  By multivariate logistic regression performed on the overall series of subjects, independent risk predictors of artery plaques were age, systolic blood pressure and TG. ConclusionPrevalence of plaques in newly diagnosed type 2 diabetes is high, suggesting that dysfunction of glucose metabolism or lipid metabolism plays an important role in the development of artherosclerosis.

Key words: Type 2 diabetes mellitus; Intra media thickness; Artery atheromatous plaques