关键词: 慢性阻塞性肺疾病；胰岛素抵抗；微量白蛋白尿

Abstract:

To  investigate the relativity of chronic obstructive pulmonary disease（COPD） and insulin resistance（IR）. MethodsA total of 330 cases of COPD were divided into four groups based on the chronic obstructive pulmonary disease diagnosis and treatment guidelines (revised edition 2007): 95 cases of  mild COPD, 95 cases of moderate COPD, 75 cases of severe COPD, 65 cases of extremely severe COPD. 40 persons served as the normal controls. Fasting plasma glucose and insulin, blood lipids, urine albumin excretion rate, and insulin sensitivity index(ISI) were determined. ResultsCompared with the normal control group, fasting blood glucose, blood lipids, urinary albumin excretion rate in different COPD groups were significantly increased, while ISI was markedly reduced(P＜0.05). Compared with the mild and moderate COPD groups, fasting blood glucose, blood lipids, urinary albumin excretion rate of the severe and very severe COPD groups were significantly increased, while ISI was significantly reduced (P＜0.05). ConclusionPatients with chronic obstructive pulmonary disease have insulin resistance, and the more serious the disease, the lower the insulin sensitivity.

Key words: Chronic obstructive pulmonary disease; Insulin resistance; Microalbuminuria