您的位置:山东大学 -> 科技期刊社 -> 《山东大学学报(医学版)》

山东大学学报(医学版) ›› 2009, Vol. 47 ›› Issue (10): 83-85.

• 论文 • 上一篇    下一篇

青年胃癌与老年胃癌临床、内镜、病理特点分析

王洪波1,宋素贞2,周成军1,王莉1,许伟华1,刘斌1,郭建强1   

  1. 1. 山东大学第二医院消化科, 济南 250033; 2. 山东中医药大学诊断教研室, 济南 250355
  • 收稿日期:2009-03-09 出版日期:2009-10-16 发布日期:2009-10-16
  • 通讯作者: 郭建强(1964- ),男,博士,主任医师,主要从事胃肠动力学研究。Email:jiangqiangg@sdu.edu.cn
  • 作者简介:王洪波(1974- ),男,博士研究生,主治医师,主要从 事胃肠肿瘤早期诊断研究。 Email:hongbo931@126.com

Clinicopathological and endoscopic characteristics of gastric carcinoma 
in young and elderly patients: a comparative study

WANG Hongbo1, SONG Suzhen2, ZHOU Chengjun1, WANG Li1,
XU Weihua1, LIU Bin1, GUO Jianqiang1   

  1. 1. Department of Gastvoenterology, Second Hosipital of Shandong University, Jinan 250033, China; 
    2. Department of Diagnosis, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
  • Received:2009-03-09 Online:2009-10-16 Published:2009-10-16

摘要:

目的对青年与老年胃癌病例的临床、病理及内镜特点进行比较,以指导临床诊断及治疗。方法对48例青年胃癌(≤40岁)和99例老年胃癌(≥65岁)的临床、病理资料进行回顾性比较分析。结果青年组男女比例为1∶1.08,老年组为3.6∶1;青年组与老年组有肿瘤家族史者分别为15例(37.5%)及12例(16.7%),差异有统计学意义(P<0.05);两组肿瘤发生部位均以远端胃为主,而老年组胃底、贲门部明显增多,占14.3%,与青年组相比差异有统计学意义(P<0.05);进展期胃癌Borrmann分型均以Ⅲ型居多,但两组Ⅲ型、Ⅳ型总和所占比例差异有统计学意义(P<0.05);两组幽门螺杆菌感染率无统计学意义(P>0.05);青年胃癌组织学以低分化腺癌、黏液腺癌、印戒细胞癌和未分化癌为主(72.9%),Lauren分型以弥漫型为主,较老年组分化程度更差,恶性度高;钡餐检查较胃镜检查更易误诊青年胃癌(P<0.05);11例早期胃癌5年生存率为100%。进展期胃癌根治术后两组生存率差异无统计学意义(P>0.05),中位生存期青年组(28.2个月,95%CI 19.8~41.3)较老年组(26.7个月,95%CI 21.0~39.8)略长,但差异无统计学意义(P>0.05)。结论青年胃癌较老年有更明显遗传倾向。病理组织学分化程度差,多为弥漫型。若能行根治手术,与老年胃癌预后无统计学差异。

关键词: 胃肿瘤 病理 胃镜 幽门螺杆菌

Abstract:

 To explore the potential differences in endoscopic and clinicopathological factors between the young and elderly population with gastric cancer(GC). MethodsIn young patients(≤40 years, n=48)  and elderly patients(≥65 years, n=99) with GC, the clinicopathological findings were compared according to clinical manifestations, gender, hereditary tendency, tumor location, histological type, growth type, prevalence of helicobacter pylori, and survival rates. ResultsIn the young and elderly groups, the male to female ratio was 1∶1.08 and 3.3∶1, respectively. 15 young patients and 12 elderly patients had a family history of tumors(P<0.05). Most tumors were found at the lower part of the stomach in both groups, but the tumors located at the upper part were more common in the elderly group than in the young group (P< 0.05). General type in both groups was Borrmann Ⅲ type, but the sum of the Borrmann Ⅲ type and Ⅳ type was statistically different (P<0.05). As compared with the elderly patients, young patients had worse differentiation and growth type. Prevalence of helicobacter pylori infection in both groups were not significantly different (P<0.05). Compared to endoscopy, Barium Xray had a higher misdiagnosis rate(P<0.05). The 5year survival rate of 11 patients with early GC was100%, and the 1, 3, 5year survival rates of young and elderly patients with advanced GC after radical gastroectomy did not statistically differ (P>0.05). The median survival time of patients was  not significantly longer in young patients (28.2months 95%CI 19.8~41.3)than elderly (26.7months, 95%CI 21.0~39.8) patients (P>0.05). ConclusionYoung patients with GC have a more obvious hereditary tendency than elderly patients, but they have a poorer pathological behavior than elderly patients. The prognosis of the young was similar to of the elderly after radical gastroectomy.

Key words: Stomach neoplasms; Pathology; Endoscopy; Helicobacter pylori

中图分类号: 

  • R735.2
[1] 刘海燕1,李陪2,高辉3,朱长军2,董智雄2. 染色体驱动蛋白KIF4A对胃癌细胞迁移和转移的影响[J]. 山东大学学报(医学版), 2013, 51(12): 25-28.
[2] 王晓蕾1,郏雁飞2,郑燕2,刘华2,汪运山2. STAT3真核表达质粒的构建及对胃癌细胞增殖的影响[J]. 山东大学学报(医学版), 2013, 51(9): 45-49.
[3] 杜宪红1,邢召全2,焦晋山1. miR-200c在CIK细胞诱导胃癌细胞凋亡中的作用[J]. 山东大学学报(医学版), 2013, 51(06): 49-52.
[4] 耿超1,潘英芳2,林森1. 肿瘤坏死因子α诱导蛋白8对胃癌细胞转移能力的影响[J]. 山东大学学报(医学版), 2013, 51(5): 85-88.
[5] 王臣臣1,顾晓萌1,王妍2,黄山英3 . TFF3在胃癌、癌前病变中的表达及与血管生成的关系[J]. 山东大学学报(医学版), 2013, 51(2): 99-103.
[6] 张艳霞1,章培军2,闫燕艳3,段爱旭4,李加善2,牛三强5. Ki-67、PCNA 和Survivin在胃肠道间质瘤组织中的表达[J]. 山东大学学报(医学版), 2013, 51(1): 67-70.
[7] 戴新1,郑燕2,郏雁飞2,肖东杰2,童书青1,汪运山2. EC1基因真核表达质粒的构建及对胃癌细胞增殖的影响[J]. 山东大学学报(医学版), 2012, 50(6): 75-.
[8] 陈宗营. HGC-1在胃癌中的表达及其与胃癌临床病理学因素和预后的关系[J]. 山东大学学报(医学版), 2012, 50(4): 87-.
[9] 蒋崇辉1,艾小红2,杨小红3,罗琼3,曹建国3. 活性氧生成在8-硝基白杨素诱导人胃癌SGC-7901细胞凋亡中的作用[J]. 山东大学学报(医学版), 2012, 50(2): 34-37.
[10] 缪玉娥,王珏,王潍博. 胃癌及其癌旁黏膜中维生素D受体的表达[J]. 山东大学学报(医学版), 2012, 50(2): 74-.
[11] 童书青1,肖东杰1,汪运山1,郏雁飞1,郑燕1,马晓丽1,戴新1,桑坦2. STAT3-siRN表达载体的构建及其对胃癌细胞株HGC-27细胞增殖的影响[J]. 山东大学学报(医学版), 2012, 50(1): 76-80.
[12] 卞晓琨1,司元全1,陆楠3,李英杰1,郏燕飞2,张义1. [J]. 山东大学学报(医学版), 2012, 50(1): 117-.
[13] 刘博学1,程欢欢2,董召刚3,王华阳2,尹作花3,宋庆旭2. MB-WCX联合SELDI-TOF-MS在胃癌诊断中的应用[J]. 山东大学学报(医学版), 2011, 49(9): 102-.
[14] 张梅娟1,2,马立宪3,徐昌青2,王义国2. Fas-670和FasL-844基因多态性与胃癌易感的相关性[J]. 山东大学学报(医学版), 2011, 49(9): 106-.
[15] 李艳,李玉,徐光辉. SELlL基因在胃癌组织中的表达及意义[J]. 山东大学学报(医学版), 2011, 49(9): 110-.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!