血必净注射液对急性有机磷中毒性心血管损伤的干预研究

山东大学学报(医学版) ›› 2008, Vol. 46 ›› Issue (12): 1169-1172.

血必净注射液对急性有机磷中毒性心血管损伤的干预研究

王颖,许荣廷,邹艳果,李锦绣

山东大学第二医院急诊科，济南 250033

收稿日期:2008-09-11 出版日期:2008-12-16 发布日期:2009-12-16
通讯作者: 许荣廷（1951- ），男，教授，主任医师。
作者简介:王颖（1983- ），女，硕士研究生，研究方向为中毒与心血管急救。
基金资助:
国家中医药（天津红日药业）血必净脓毒症研究基金资助课题（20070607）。

Intervention of Xuebijing injection in acute organophosphate poisoning complicated with cardiovascular injury

WANG Ying, XU Rongting, ZOU Yanguo, LI Jinxiu

Department of Emergency, Second Hospital of Shandong University， Jinan 250033， China

Received:2008-09-11 Online:2008-12-16 Published:2009-12-16

摘要/Abstract

摘要：

目的观察血必净注射液对急性有机磷中毒性心血管损伤患者外周血中性粒细胞核转录因子-kappa B（NF-κB）的活化程度及损伤预后的影响。方法将70例急性有机磷中毒合并心血管损伤患者随机分为阳性对照组（35例）和实验组（35例），用免疫酶组织化学法检测其外周血中性粒细胞NF-κB的活化程度，并观察患者血清心肌酶活性值的变化。结果 ①实验组死亡率低于对照组（P＜0.05）；②对照组NFκB活化程度高于实验组（P＜0.05）；③血必净注射液呈剂量依赖性地抑制中性粒细胞NF-κB的活性（P＜0.05）；④实验组血清心肌酶活性值恢复程度优于对照组，且与血必净注射液用量呈剂量依赖性（P＜0.05）。结论早期联合应用血必净注射液和常规治疗药物，可改善急性有机磷中毒并发心血管损伤患者的预后，提高救治成功率。

关键词: 血必净注射液；有机磷中毒；心血管系统；损伤；免疫组织化学；核转录因子κB

Abstract:

Objective To observe the effects of Xuebijing injection on nuclear factor-kappa B activation of PMN and the prognosis of cardiovascular injury. Methods 70 cases of acute organophosphate poisoning complicated with cardiovascular injury were divided into the positive control group (35 cases)and the test group(35 cases) at random. The enzyme labeled immunohistochemical method was used to determine the NF-κB activation degree. Changes of myocardial enzyme were also observed. Results ① Death rate of the test group was lower than that of the control group(P＜0.05). ② The NF-κB activation degree of the control group was higher than that of the test group(P＜0.05).　③ Xuebijing injection suppressed the activation of NF-κB on dosage(P＜0.05). ④ The degree of myocardial enzyme recovery of the test group was superior to that of the control group and was dose-dependent on Xuebijing injection(P＜0.05). Conclusion Xuebijing injection in combination with routine therapies has obvious efficiency on increasing the success rate of acute organophosphorus pesticide poisoning patients complicated with cardiovascular injury.

Key words: Xuebijing Injection; Organophosphate poisoning; Cardiovascular systerm; Injuries; Immunohistochemistry; Nuclear factor-kappa B

中图分类号:

R541.78

王颖,许荣廷,邹艳果,李锦绣. 血必净注射液对急性有机磷中毒性心血管损伤的干预研究[J]. 山东大学学报(医学版), 2008, 46(12): 1169-1172.

WANG Ying, XU Rongting, ZOU Yanguo, LI Jinxiu. Intervention of Xuebijing injection in acute organophosphate poisoning complicated with cardiovascular injury[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2008, 46(12): 1169-1172.

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