婴儿期免疫干预对毛细支气管炎预后的影响

山东大学学报(医学版)

婴儿期免疫干预对毛细支气管炎预后的影响

刘向红¹，张岩²

1．山东大学医学院，济南市儿童医院呼吸科，济南 250022；
2. 山东大学齐鲁医院儿科，济南 250012

收稿日期:2007-11-03 修回日期:1900-01-01 出版日期:2008-10-16 发布日期:2008-10-16
通讯作者: 刘向红

Effect of immunologic intervention for bronchiolitis in infancy

刘向红¹，张岩²

1. Department of Pediatrics, Jinan Children′s Hospital, School of Medicine, Shandong University, Jinan 250022, China;
2. Department of Pediatrics, Qilu Hospital of Shandong University， Jinan 250012, China

Received:2007-11-03 Revised:1900-01-01 Online:2008-10-16 Published:2008-10-16
Contact: LIU Xiang-hong

摘要/Abstract

摘要： 目的观察婴儿期进行免疫干预对改善毛细支气管炎患儿Th1/Th2免疫紊乱和复发喘息的影响。方法年龄小于6个月毛支患儿50例，随机分为毛支观察组和毛支对照组各25例，同时设正常对照婴儿15例，毛支观察组给予卡介苗素治疗1年，治疗前后分别对毛支观察组和毛支对照组及正常对照组用ELISA方法检测血清IL-10、IL-12，并随访两年内喘息发作次数和喘息持续时间。结果①毛支观察组和毛支对照组IL-10明显高于正常对照组，IL-12明显低于正常对照组（P＜0.001）。②毛支观察组经卡介苗多糖核酸治疗后IL-10明显降低，IL-12明显升高。③反复喘息次数明显减少，喘息时间明显缩短。结论毛支患儿存在着Th1/Th2免疫功能紊乱，婴儿期进行免疫干预能明显改善毛支患儿Th1/Th2免疫紊乱状况，并能预防哮喘的发生、发展。

关键词: 哮喘, 卡介苗, 毛细支气管炎

Abstract: To explore the effects of immunologic intervention on the Th1/Th2 immunologic derangement and relapse gasp in acute bronchiolitis. Methods50 infants less than 6 months with acute bronchiolitis were randomly divided into 2 groups: the experimental group and the control group. Meanwhile 15 normal infants served as the blank control. The control group was treated with routine therapies and the experimental group was treated with polysaccharide nucleic acid fraction of BCG for one year besides routine therapy. The levels of serum IL-10 and IL-12 were determined by using ELISA before and after the treatment. Also, times and duration of gasping were followed up for 2 years. ResultsThe IL-10 level was significantly higher in the experimental group than that in the blank control group, however the IL-12 level was significantly lower in the experimental group than that in the blank control group（P＜0.001). After polysaccharide nucleic acid fraction of BCG treatment, the IL10 level was significantly decreased and the IL-12 level was significantly increased（P＜0.01, also, the times of gasping in 2 years decreased（P＜0.001) and the duration of gasping was obviously shortened. Conclusion Immunologic intervention can improve the immunologic derangement of Th1/Th2 in bronchiolitis and prevents the development of asthma.

Key words: Bronchiolitis, Vaccine, Asthma

中图分类号:

R725.6

刘向红,张岩 . 婴儿期免疫干预对毛细支气管炎预后的影响[J]. 山东大学学报(医学版), 2008, 46(10): 974-976.

刘向红,张岩. Effect of immunologic intervention for bronchiolitis in infancy[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2008, 46(10): 974-976.

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