前列腺增生症患者逼尿肌中转化生长因子的变化及其意义

山东大学学报(医学版)

前列腺增生症患者逼尿肌中转化生长因子的变化及其意义

韩增篪¹，徐忠华¹，刘　犇²，阎　磊¹，周尊林¹，陈修德¹，刘海南¹，刘照旭¹，范医东¹，郑宝钟¹

1. 山东大学齐鲁医院泌尿外科，山东济南 250012；2. 浙江大学医学院第一附属医院泌尿外科，浙江杭州 310003

收稿日期:2006-05-15 修回日期:1900-01-01 出版日期:2007-01-24 发布日期:2007-01-24
通讯作者: 徐忠华

Changes of transforming growth factor-β of human detrusor after bladder outlet obstruction induced by benign prostatic hyperplasia

HAN Zeng-chi¹，XU Zhong-hua¹，LIU Ben²，YAN Lei¹，ZHOU Zun-lin¹，CHEN Xiu-de¹，LIU Hai-nan¹，LIU Zhao-xu¹，FAN Yi-dong¹，ZHENG Bao-zhong¹

1. Department of Urology, Qilu Hospital of Shandong University, Jinan 250012;2. Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou 310003

Received:2006-05-15 Revised:1900-01-01 Online:2007-01-24 Published:2007-01-24
Contact: XU Zhong-hua

摘要/Abstract

摘要： 目的：探讨前列腺增生（benign prostatic hyperplasia ，BPH)造成患者膀胱出口梗阻（bladder outlet obstruction，BOO）后膀胱逼尿肌中转化生长因子β(transforming growth factor-β，TGF-β)的表达变化。方法：BPH患者54例,分为逼尿肌稳定组（33例）和逼尿肌过度活动（detrusor overactivity，DO）组（21例）。对照组15例为同期在我院因膀胱癌施行开放手术的男性患者，应用免疫组化观察各组逼尿肌中TGF-β的表达。结果：BPH患者包括逼尿肌稳定组与DO组TGF-β的表达水平均明显高于对照组，在对照组、逼尿肌稳定组、DO组之间两两比较差异均有统计学意义（P<0.01）。结论：BPH造成BOO后逼尿肌中TGF-β的表达明显增高，这种变化可能与BOO后膀胱逼尿肌纤维化及DO相关。

Abstract: Objective: To investigate the changes of human detrusor transforming growth factor -β(TGF-β) after bladder outlet obstruction (BOO) induced by benign prostatic hyperplasia (BPH). Methods： Obstructive detrusor stability was found in 33 patients and obstructive detrusor overactivity in 21 patients; and bladder tumor in 15 men (control) who were operated on in the same period. TGF-β was measured by immunohistochemical staining. Results： The TGF-βlevels of the obstructive groups were much higher than those in the control group. There were significant differences among the three groups (P<0.01). Conclusion： The TGF-β level is significantly higher after BOO, which might be correlated with denervation supersensitivity and detrusor overactivity.

Key words: Prostatic hyperplasia, Transforming growth factor bata, Detrusor overactivity

中图分类号:

R711.32

韩增篪,徐忠华,刘　犇,阎　磊,周尊林,陈修德,刘海南,刘照旭,范医东,郑宝钟 . 前列腺增生症患者逼尿肌中转化生长因子的变化及其意义[J]. 山东大学学报(医学版), 2007, 45(1): 59-61.

HAN Zeng-chi,XU Zhong-hua,LIU Ben,YAN Lei,ZHOU Zun-lin,CHEN Xiu-de,LIU Hai-nan,LIU Zhao-xu,FAN Yi-dong,ZHENG Bao-zhong. Changes of transforming growth factor-β of human detrusor after bladder outlet obstruction induced by benign prostatic hyperplasia[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(1): 59-61.

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