糖神胶囊工艺改革及量效关系的实验研究

山东大学学报(医学版)

糖神胶囊工艺改革及量效关系的实验研究

钟丽红¹,杨竞²,张秀娟³

山东大学 1. 齐鲁医院药剂科； 2. 齐鲁医院中医科； 3. 医学院，山东济南 250012

收稿日期:2006-02-10 修回日期:1900-01-01 出版日期:2006-08-24 发布日期:2006-08-24
通讯作者: 钟丽红

ZHONG li-hong¹,YANG Jing²,ZHANG Xiu-juan³

Received:2006-02-10 Revised:1900-01-01 Online:2006-08-24 Published:2006-08-24
Contact: ZHONG li-hong

摘要/Abstract

摘要： 目的：比较糖神胶囊普通制剂和不同剂量新工艺制剂的疗效关系。方法：制备链脲佐菌素糖尿病大鼠模型，分别用普通制剂和不同剂量新工艺制剂的糖神胶囊灌胃，观察8周。检测服药前后空腹血糖（FBG）、红细胞中山梨醇（RBCS）的含量、运动神经传导速度（MNCV）、甩尾反射潜伏期（TFL）。结果：与普通制剂相比，新工艺制剂的糖神胶囊可降低链脲佐菌素糖尿病大鼠的FBG、RBCS含量，加快MNCV，延长TFL（P均＜0.05）。1/2剂量的新工艺制剂与普通制剂疗效相似。结论：糖神胶囊新工艺制剂可明显提高药效，减少服药剂量。

Abstract: To compare the effect of Tangshen capsule's normal preparations with new preparations. Methods: Diabetic rat models induced by streptozotocin administered through intragastricinfusion with normal preparations of Tangshen capsule and different dosages of Tangshen capsule made with new technics respectively, were observed for 8 weeks.The foreandaft fasting blood glucose (FBG), content of sorbitol in red cells (RBCS), conduct velocity of the motor nerve (MNCV) and tail flick latency (TFL) were detected. Results: Compared with the normal preparation, the new technical preparations of the Tangshen capsule could reduce the FBG, RBCS, speed up the MNCV and make the TFL longer（P＜0.05）. Half dosage of the new technical prepartions and full dosage of normal prepartions had the same effect. Conclusion: Tangshen capsule prepared with new technical method markedly improves the effect and reduces dosage of drugs.

Key words: Tangshen capsule, Technology, pharmaceutical, Sorbitol, Rats, Wistar

钟丽红,杨竞,张秀娟 . 糖神胶囊工艺改革及量效关系的实验研究[J]. 山东大学学报(医学版), 2006, 44(8): 846-848.

ZHONG li-hong,YANG Jing,ZHANG Xiu-juan. [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2006, 44(8): 846-848.

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