NFκB、bcl-2、bax在胃不典型增生、胃癌中的表达及其意义

NFκB、bcl-2、bax在胃不典型增生、胃癌中的表达及其意义

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山东大学学报(医学版)

崔涛¹,朱祖安²,刘莹¹费素娟²,李凤朝²

徐州医学院 1.病理学教研室； 2.附属医院消化科，江苏徐州 221006

收稿日期:2006-03-29 修回日期:1900-01-01 出版日期:2006-07-24 发布日期:2006-07-24
通讯作者: 崔涛

CUI Tao¹,LIU Ying²,ZHU Zu-an¹,FEI Su-juan²,LI Feng-chao²

徐州医学院 1.病理学教研室； 2.附属医院消化科，江苏徐州 221006

Received:2006-03-29 Revised:1900-01-01 Online:2006-07-24 Published:2006-07-24
Contact: CUI Tao

摘要： 探讨核因子κB（nuclear factor kappa B， NFκB）、bcl2及bax在胃不典型增生及胃癌中的表达及在胃癌发生中的作用。方法：采用免疫组化Power Vision两步法检测84例胃癌和54例胃不典型增生组织中NFκB、bcl2及bax的表达，TNNEL法染色检测凋亡指标的改变。结果：NFκB、bcl2、bax在84例胃癌组织中的阳性表达率分别为59.52%、52.38%、16.67%，在33例胃轻度不典型增生组织中阳性表达率分别为24.24%、21.21%、33.33%，三者在胃癌与轻度不典型增生组之间差异有统计学意义（P＜0.05)。NFκB、bcl2表达与肿瘤的大小相关（P＜0.05），NFκB与bcl2之间呈正相关（P＜0.05)。在轻度不典型增生、重度不典型增生与胃癌组织中AI分别为（1.29±0.50）％、（0.96±0.36）％、（0.70±0.43）％，轻度不典型增生与重度不典型增生、胃癌之间差异均有统计学意义（P＜0.05) 。结论：在胃癌中NFκB可通过上调bcl2的表达、改变bcl2与bax的比值而抑制肿瘤细胞凋亡，进而影响肿瘤的生长、浸润、转移。

Abstract: To explore the expression and role of NFκB, bcl2 and bax protein in gastric cancer and atypical hyperplasia. Method： The expressions of NFκB,bcl2 and bax were determined with Power VisionTM immunohistochemical analysis in 84 patients with gastric cancer and 54 with gastric atypical hyperplasia. Apoptosis was detected by terminal deoxynucleotidyl transferasemediated dUTPbiotin nick end labeling(TUNEL). Result： The rates of NFκB（59.52%） and bcl2（52.38%）in gastric cancer were significantly higher than those in gastric atypical hyperplasia (P＜0.05）. Overexpression of NFκB in gastric cancer was related to tumor size (P＜0.05）, and there was positive correlation between the expression of NFκB and of bcl2. The apoptosis index(AI) gradually decreased to （1.29±0.50）％, （0.96±0.36）％, and （0.70±0.43）％ in low dysplasia, high dysplasia and gastric cancer, in which there were significant differences (P＜0.05）. Conclusions： NFκB may inhibit the

Key words: Gastriccarcinoma, Gastric atypical hyperplasia, NFkappa B, Genes,bcl2, Genes, bax

崔涛,朱祖安,刘莹费素娟,李凤朝 . NFκB、bcl-2、bax在胃不典型增生、胃癌中的表达及其意义[J]. 山东大学学报(医学版), 2006, 44(7): 689-693.

CUI Tao,LIU Ying,ZHU Zu-an,FEI Su-juan,LI Feng-chao. [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2006, 44(7): 689-693.

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