三七皂甙对急性脑梗塞患者血浆和脑脊液MCP-1、ET含量的影响

山东大学学报(医学版)

三七皂甙对急性脑梗塞患者血浆和脑脊液MCP-1、ET含量的影响

王频，于君2，周庆博1，谢兆宏1，毕建忠1，王晓云1，刘震1，孙琳1，王萍

1. 山东大学第二医院神经内科，山东济南 250033;2. 山东中医药大学附属医院感染管理科，山东济南 250012

收稿日期:2005-10-29 修回日期:1900-01-01 出版日期:2006-05-24 发布日期:2006-05-24
通讯作者: 王频

Role of saponins on MCP1 and ET in serum and cerebrospinalfluid of patients with acute brain infarction

WANG Pin, YU Jun, ZHOU Qing-bo, XIE Zhao-hong, BI Jian-zhong, WANG Xiao-yun, LIU Zhen, SUN Lin, WANG Ping

.Department of Neurology,Second Hospital of Shandong University, Jinan 250033, Shandong, China;2.Department of Prevention of Infection, Affiliated Hospital of Shandong University ofTraditional Chinese Medicine, Jinan 250012, Shandong, China

Received:2005-10-29 Revised:1900-01-01 Online:2006-05-24 Published:2006-05-24
Contact: WANGPIN

摘要/Abstract

摘要： 研究三七皂甙对急性脑梗塞患者血浆和脑脊液单核细胞趋化因子（MCP1）和内皮素（ET）水平在不同时段变化的影响。方法：用酶联免疫法和放射免疫法测定MCP1和ET在不同时间血浆和脑脊液含量的变化情况，及应用三七皂甙治疗后的影响。结果：脑梗塞患者血浆MCP1和ET的水平明显增加，三七皂甙组各时间段MCP1和ET的含量与对照组比较有显著性差异（P<0.05）,MCP1在第3天达到峰值，第5天开始下降。ET在第3～5天达峰值，之后逐渐下降，第10天的含量仍高于第1天。脑梗塞48?h后患者脑脊液MCP1和ET的含量亦明显升高。应用三七皂甙后血浆MCP1和ET的水平均显著低于对照组（P<0.01）。结论：脑梗塞后血浆和脑脊液MCP1和ET水平明显增高（P<0.05）；MCP1和ET的变化有一定相关性（r=0.852）。三七皂甙对脑梗塞后血浆和脑脊液MCP1和ET的表达有部分抑制作用，这可能是三七皂甙减轻脑梗塞后缺血缺氧的分子机制之一。

Abstract: To investigate the concention changes of the monocyte chemoattractant protein1(MCP1) and the endothelia(ET) in serum and cerebrospinal fluid(csf) of patients with acute brain infarction treated by saponins. Methods: The level of MCP1and ET in different times in serum and cerebrospinal were determined by enzymelinked immunoadsordent (ELLISA) and radioreceptor assay (RRA). CSF samples were obtained on the first day of the onset and at 48 hours later during the lumbar puncture procedure. Results: Both the serum levels of MCP1 and ET in different times were notably higher in ischemic stroke than healthy man(P<0.05). The level of MCP1 reached the peak on the day 3 and then decreased on the day 510, and that of ET, too.The levels of MCP

Key words: Brain infarction, Saponins, Monocyte chemoattractant protein1,

王频,于君,周庆博,谢兆宏,毕建忠,王晓云,刘震,孙琳,王萍. 三七皂甙对急性脑梗塞患者血浆和脑脊液MCP-1、ET含量的影响[J]. 山东大学学报(医学版), 2006, 44(5): 455-458.

WANG Pin,YU Jun, ZHOU Qing-bo,XIE Zhao-hong,BI Jian-zhong,WANG Xiao-yun,LIU Zhen,SUN Lin,WANG Ping. Role of saponins on MCP1 and ET in serum and cerebrospinalfluid of patients with acute brain infarction[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2006, 44(5): 455-458.

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