Abstract: To study the effect of traditional Chinese medicine “Fuganling” （FGL）on liver injury induced by CCl4 in rabbits. Methods: Experimental liver injury models of rabbits were established by hyodermic injection of CCl4 oil solution(10%, 5?ml/kg), and then they were distributed to pumping brine group(control), CCl4 group, and high, median, low dose FGL group. The blood serum aspartate aminotransferase (AST), the glutamicpyruvic transaminase(ALT), the rglutamltransferase(rGT), the gross protein, the albumin, and the globin were tested 2 months later. Results: (1) The body weights decreased obviously in CCl4indued injury group compared with brine group（P<0.01），　while they decreased unconspicuously in FGL therapy groups compared with brine groups（P>0.05）;　(2) Levels of serum AST, ALT and　rGT in CCl4induced injury groups increased obviously compared with FGL therapy groups （P<0.01）; (3) CCl4indued liver MDA enhance was decreased by FGL evidently （P<0.01）; (4) Microscope and electron microscopy revealed that the liver structure had been ameliorated in Fuganling treatment groups. Conclusion: Fuganling has obviously protection effect on liver injury.

Key words: Carbon tetrachloride, Liver function test, Rabbit, Fuganling