PDGF及其受体在大鼠胰腺纤维化中的作用

山东大学学报(医学版)

PDGF及其受体在大鼠胰腺纤维化中的作用

王东盛1，刘倩2，寇妍3

1. 山东大学医学院, 山东济南 250012； 2. 山东省千佛山医院消化科，山东济南 250014；3. 济南第四人民医院烧伤科, 山东济南 250031

收稿日期:2005-08-12 修回日期:1900-01-01 出版日期:2006-04-24 发布日期:2006-04-24

Expression of PDGF and its receptor on pancreas fibrosis in rats

WANG Dongsheng1, LIU Qian2, KOU Yan3

1. School of Medicine, Shandong University, Jinan 250012; 2.Department of Digestion,Shandong Provincial Qianfoshan Hospital, Jinan 250014; 3. Department of Burn, Jinan Fourth People′s Hospital, Jinan 250031

Received:2005-08-12 Revised:1900-01-01 Online:2006-04-24 Published:2006-04-24

摘要/Abstract

摘要： 目的：探讨血小板源生长因子（PDGF）及其受体（PDGFR）在胰腺纤维化过程中的作用及意义。方法: 通过胰管内注射2%三硝基苯磺酸(TNBS）的方法制作大鼠胰腺纤维化模型，采用免疫组化方法检测2、3、4、5、6周PDGF 、PDGFR及α平滑肌肌动蛋白（αSMA）在大鼠胰腺组织中的表达。结果:第4周，PDGFB、PDGFRβ、αSMA在模型组的表达均强于对照组（P均<0.01）。αSMA与PDGFB、PDGFRβ定量分析呈正相关（P均<0.01），与PDGFA、PDGFRα无相关关系（P均>0.05）。模型组中不同时期PDGFB及PDGFRβ表达分别强于PDGFA、PDGFRα（P均<0.01）。结论: PDGF、PDGFR在慢性胰腺炎发生纤维化过程中具有重要作用，其中以PDGFB及PDGFRβ为主。

Abstract: Objective: To study the expression and significance of PDGF and its receptor in the process of pancreas fibrosis. Methods: The animal model of chronic pancreatitis was established by injection of 2% TNBS to rat′s pancreatic duct. Expressions of PDGF, PDGFR and αSMA were determined in pancreas tissues in different stages by using immnnohistochemistry technique. Results: Expressions of PDGFB, PDGFRβ and αSMA were stronger in model than in control group on the fourth week. There was a positive correlation between αSMA and PDGFB and PDGFRβ, and no correlation between αSMA and PDGFA and PDGFRα. The expressions of PDGFB and PDGFRβ were stronger than those of PDGFA and PDGFRα with a significant difference in model group. Conclusion: PDGFB and PDGFRβ are mainly to act play a key role in pancreas fibrosis and development.

Key words: Receptors, plateletderived growth factor, Pancreatitis, Rat, Wistar

中图分类号:

R576

王东盛,刘倩,寇妍. PDGF及其受体在大鼠胰腺纤维化中的作用[J]. 山东大学学报(医学版), 2006, 44(4): 360-363.

WANG Dongsheng,LIU Qian,KOU Yan. Expression of PDGF and its receptor on pancreas fibrosis in rats[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2006, 44(4): 360-363.

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