慢性乙型病毒性肝炎、肝癌组织HLAⅠ类抗原的表达及意义

山东大学学报(医学版)

慢性乙型病毒性肝炎、肝癌组织HLAⅠ类抗原的表达及意义

程宝泉1，谢英慧2，刘春涛1，钟宁1，樊薇1，张尚忠1

1. 山东大学齐鲁医院消化内科，山东济南 250012； 2.山东大学东校区医院, 山东济南 250100

收稿日期:2005-01-10 修回日期:1900-01-01 出版日期:2006-04-24 发布日期:2006-04-24

Hepatic tissue expression of HLAI in patients with chronic hepatitis B virus and hepatocellular carcinoma

CHENG Baoquan1,　XIE Yinghui2,　LIU Chuntao1,　ZHONG Ning1,　FAN Wei1,　ZHANG Shangzhong1

1. Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;2. The east Campus Hospital of Shandong University, Jinan 250100, Shandong, China

Received:2005-01-10 Revised:1900-01-01 Online:2006-04-24 Published:2006-04-24

摘要/Abstract

摘要： 目的：探讨慢性乙型肝炎、肝癌组织中人类白细胞抗原I（HLAI）的表达和临床意义。方法:应用流式细胞仪对51例慢性乙型肝炎患者肝组织和43例原发性肝癌癌组织中的HLAI抗原进行检测。结果:肝癌组织中HLAI抗原表达为36.47±19.38，明显低于慢性乙肝的79.54±41.55和正常肝组织的81.86±46.53（P均＜0.01），而慢性乙型肝炎肝组织和正常肝组织HLAI类抗原表达无明显差异（P＞0.05），伴有肝内和(或)淋巴结转移的肝癌组织中HLAI抗原表达较无转移组明显降低（22.83±11.59 vs 46.28±23.16，P＜0.05);HLAI类抗原表达与血清AFP水平呈明显负相关（r=-0.741?1, P＜0.01）,但与肝癌组织分化程度呈明显正相关(r=0.805?1, P ?.05)。结论:HLAI抗原表达异常与肝癌的发生和转移密切相关。［关键词］HLAI类抗原;肝炎，乙型;癌，肝细胞

Abstract: HObjective: To study the expression of human leucocyte antigen I（HLAⅠ） in patients with hepatitis B virus infection and hepatocellular carcinoma. Method: HLAI in 51 liver tissues of viral hepatitis B and 43 tumor tissues of hepatocellular carcinoma was examined by flow cytometry. Results: The expression of HLAI was lower in tumor tissue of hepatocellular carcinoma(36.47±19.38) than that in liver tissue of chronic viral hepatitis B(79.54±41.55, P＜0.01)and normal liver tissues(81.86±46.53, P＜0.01), but no significant difference was found between the normal liver tissues and tissues of chronic viral hepatitis(P＞0.05). Moreover, the expression of HLAI in tumor tissues with lymphnode involvement was lower than in tumors without involvement(22.83±11.59 vs 46.28±23.16) (P＜0.05). There was a reverse relation between the expression of HLAI and the level of serum alpha fetoprotein (r=-0.741?1, P＜0.01), but a positive relation was found between with histological differenciation grading(r=0.805?1, P＜0.05). Conclusion: Low expression of HLAI is relation to development and metastasis of hepatocellular carcinoma.

Key words: LAI antigens, Hepatitis B, Carcinoma, hepatocellular

中图分类号:

R512.62

程宝泉,谢英慧,刘春涛,钟宁,樊薇,张尚忠. 慢性乙型病毒性肝炎、肝癌组织HLAⅠ类抗原的表达及意义[J]. 山东大学学报(医学版), 2006, 44(4): 357-359.

CHENG Baoquan,XIE Yinghui,LIU Chuntao,ZHONG Ning,FAN Wei,ZHANG Shangzhong. Hepatic tissue expression of HLAI in patients with chronic hepatitis B virus and hepatocellular carcinoma[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2006, 44(4): 357-359.

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