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山东大学学报 (医学版) ›› 2020, Vol. 58 ›› Issue (12): 72-76.doi: 10.6040/j.issn.1671-7554.0.2020.0838

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改良颈腮腺入路切除咽旁间隙高位良性肿瘤

吴昊1,徐克2,韩靓3,徐菲菲1,王东琴1,达鹏1,殷勇1   

  1. 1. 南通大学附属医院耳鼻咽喉-头颈外科, 江苏 南通 226001;2. 南通大学附属医院口腔-颌面外科, 江苏 南通 226001;3. 南通肿瘤医院头颈外科, 江苏 南通 226001
  • 发布日期:2020-12-08
  • 通讯作者: 吴昊. E-mail:entwuhao@163.com
  • 基金资助:
    2018年南通市科技局重点疾病的规范化诊疗项目(MS22018011)

Modified cervical-parotid approach in the resection of upper benign tumors in the parapharyngeal space

WU Hao1, XU Ke2, HAN Liang3, XU Feifei1, WANG Dongqin1, DA Peng1, YIN Yong1   

  1. 1. Department of Otolaryngology Head Neck Surgery, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, China;
    2. Department of Stomatology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, China;
    3. Department of Head Neck Surgery, Nantong Tumor Hospital, Nantong 226001, Jiangsu, China
  • Published:2020-12-08

摘要: 目的 探讨改良颈腮腺入路在高位咽旁间隙良性肿瘤手术中的应用疗效。 方法 7例咽旁间隙良性肿瘤患者,术前影像学检查提示为高位、肿瘤巨大、哑铃型且边界欠清,采用改良颈腮腺入路术式,解剖辨认面神经总干及颞面干后,于外耳道软骨前方、腮腺的后缘以及颞面干的上方间隙向深部分离至肿瘤上极,剥离子分离并下压肿瘤与下方常规颈部自下而上肿瘤游离会师后,从颌下区取出肿瘤。腮腺浅叶不切除,面神经分支不做过多解剖。 结果 所有患者均一次性完整切除肿瘤;术后病理示多形性腺瘤6例,神经鞘瘤1例;术中出血均少于300 mL;1例患者出现术后同侧眼睑轻度闭合障碍,两周后完全正常;所有患者面容美学保存理想。 结论 对于高位咽旁间隙良性肿瘤采用改良颈腮腺入路术式,不仅可以安全完整地切除肿瘤,同时由于减少了面神经及腮腺浅叶的处置,术后相关神经并发症及腮腺区凹陷性改变的发生率下降。

关键词: 咽旁间隙, 肿瘤, 良性, 外科手术, 手术入路

Abstract: Objective To investigate the efficacy of modified cervical-parotid approach in resection of upper benign tumors in the parapharyngeal space. Methods A total of 7 patients were enrolled. Preoperative imaging showed big-sized, dumbbell-shaped tumors with unclear boundary. The modified cervical-parotid approach was adopted. After the main trunk and temporal branch of the facial nerves were identified, the upper part of the tumors was separated through the anterior cartilage of the external auditory canal, the posterior margin of parotid gland and the upper part of temporal branch. The tumors were then isolated and removed from the submaxillary region. During the procedure, the superficial lobe of the parotid gland was preserved, and only the necessary facial nerve branches were dissected. Results All tumors were completely removed in one stage operation. Postoperative pathology showed pleomorphic adenoma in 6 cases and schwannoma in 1 case. The hemorrhage volume was less than 300 mL. Mild peripheral facial paralysis occurred in 1 patient, who returned normal 14 days later. All patients had satisfactory cosmetic outcomes. Conclusion The modified cervical-parotid approach can remove the tumors safely and completely, reduce the exposure of facial nerves and superficial lobe of the parotid gland, and reduce the incidence of postoperative neuropathic complications and parotid pitting changes.

Key words: Parapharyngeal space, Tumor, Benign, Surgery, Surgical approach

中图分类号: 

  • R766
[1] Kuet ML, Kasbekar AV, Masterson L, et al. Management of tumors arising from the parapharyngeal space: a systematic review of 1, 293 cases reported over 25 years [J]. Laryngoscope, 2015, 125(6): 1372-1381.
[2] Stanley RE. Parapharyngeal space tumours [J]. Ann Acad Med Singapore, 1991, 20(5): 589-596.
[3] Kanzaki S, Nameki H. Standardised method of selecting surgical approaches to benign parapharyngeal space tumours, based on pre-operative images [J]. J Laryngol Otol, 2008, 122(6): 628-634.
[4] 文锋, 沈泓, 高为华, 等. 72例咽旁间隙肿瘤患者的诊疗分析[J]. 临床耳鼻咽喉头颈外科杂志, 2018, 32(17): 1343-1347. WEN Feng, SHEN Hong, GAO Weihua, et al. Analysis and surgical treatment of 72 cases of parapharyngeal space tumors [J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2018, 32(17): 1343-1347.
[5] Wang XL, Xu ZG, Wu YH, et al. Surgical management of parapharyngeal lymph node metastasis of thyroid carcinoma: a retrospective study of 25 patient s[J]. Chin Med J(Engl), 2012, 125(20): 3635-3639.
[6] Singh M, Gupta SC, Singla A. Our experiences with parapharyngeal space tumors and systematic review of the literature [J]. Indian J Otolaryngol Head Neck Surg, 2009, 61(2): 112-119.
[7] Batsakis JG, Sneige N. Parapharyngeal and retropharyngeal space diseases [J]. Ann Otol Rhinol Laryngol, 1989, 98(4 pt 1): 320-321.
[8] Shi XL, Tao L, Li XM, et al. Surgical management of primary parapharyngeal space tumors: a 10-year review [J]. Acta Oto-Laryngol, 2017, 137(6): 656-661.
[9] Riffat F, Dwivedi RC, Palme C, et al. A systematic review of 1143 parapharyngeal space tumors reported over 20 years [J]. Oral Oncol, 2014, 50(5): 421-430.
[10] Som PM, Curtin HD. Lesions of the parapharyngeal space. Role of MR imaging [J]. Otolaryngol Clin N Am, 1995, 28(3): 515.
[11] Hong Y, Hu J, Liang Z. Analysis of clinical diagnosis and treatment of 112 cases of parapharyngeal space tumors [J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2015, 29(11): 994-997.
[12] Gupta A, Chazen JL, Phillips CD. Imaging evaluation of the parapharyngeal space [J]. Otolaryngol Clin North Am, 2012, 45(6): 1223-1232.
[13] Najeeb T, Khan M. Sympathetic chain schwannoma resembling carotid body tumour [J]. J Coll Physicians Surg Pak, 2016, 26(6 suppl): 68-70.
[14] Chen WL, Wang WJ, Huang ZQ, et al. Osteotomy in the vertical ramus outside the mandibular foramen for tumours in the parapharyngeal space [J]. J Craniomaxillofac Surg, 2014, 42(3): 29-32.
[15] 王晓敏, 李慧, 陈德尚, 等. 高位咽旁间隙良性肿瘤的手术治疗[J]. 临床耳鼻咽喉头颈外科杂志, 2018, 32(23): 1804-1809. WANG Xiaomin, LI Hui, CHEN Deshang, et al. The surgical management of upper parapharyngeal regions [J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2018, 32(23): 1804-1809.
[16] 黄乃邦, 达鹏, 卢军, 等. 不同下颌骨截骨方式在咽相关区域肿瘤手术中的应用[J]. 山东大学学报(医学版), 2015, 53(8): 79-82. HUANG Naibang, DA Peng, LU Jun, et al. Applications of different mandibulotomy approaches to the resection of pharyngeal region tumors [J]. Journal of Shandong University(Health Sciences), 2015, 53(8): 79-82.
[17] Ducic Y, Oxford L, Pontius AT. Transoral approach to the superomedial parapharyngeal space [J]. Otolaryngol Head Neck Surg, 2006, 134(3): 466-470.
[18] Dimitrijevic MV, Jesic SD, Mikic AA, et al. Parapharyngeal space tumors: 61 case reviews [J]. Int J Oral Maxillofac Surg, 2010, 39(10): 983-989.
[19] Cassoni A, Terenzi V, Della Monaca M, et al. Parapharyngeal space benign tumours: our experience [J]. J Craniomaxillofac Surg, 2014, 42(2): 101-105.
[20] Papadogeorgakis N, Petsinis V, Goutzanis L, et al. Parapharyngeal space tumors: surgical approaches in a series of 13 cases [J]. Int J Oral Maxillofac Surg, 2010, 39(3): 243-250.
[21] Betka J, Chovanec M, Klozar J, et al. Transoral and combined transoral-transcervical approach in the surgery of parapharyngeal tumors [J]. Eur Arch Otorhinolaryngol, 2010, 267(5): 765-772.
[22] 黄卓珊, 张大明, 陈伟良, 等. 2种手术入路在巨大咽旁间隙肿瘤切除术中的效果比较[J]. 中国口腔颌面外科杂志, 2018, 16(1): 56-59. HUANG Zhuoshan, ZHANG Daming, CHEN Weiliang, et al. Endoscopy-assisted transoral versus endoscopy-assisted transcervical minimal incision plus mandibular osteotomy approach in resection of large parapharyngeal space tumors [J]. China Journal of Oral and Maxillofacial Surgery, 2018, 16(1): 56-59.
[23] Liu Y, Yu HJ, Zhen HT. Transoral and endoscope-assisted transoral approaches to resecting benign tumours of the parapharyngeal space located in the medial portion of the carotid sheaths and extending toward the skull base: our experience [J]. J Laryngol Otol, 2018, 132(8): 748-752.
[24] Okamoto I, Tsukahara K, Sato H. Parapharyngeal space tumor surgery using a modified cervical-parotid approach [J]. Acta Oto-Laryngol, 2018, 138(2): 165-169.
[25] 刘丰, 俞志维, 刘胜文, 等. 咽旁间隙肿瘤手术入路10例分析[J]. 口腔颌面外科杂志, 2015, 25(3): 216-219. LIU Feng, YU Zhiwei, LIU Shengwen, et al. Surgical approaches of parapharyngeal space tumors: report of 10 cases [J]. Journal of Oral and Maxillofacial Surgery, 2015, 25(3): 216-219.
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