克氏综合征的生育相关研究进展

doi:10.6040/j.issn.1671-7554.0.2019.765

摘要/Abstract

摘要： 克氏综合征是男性不育中最常见的遗传性疾病。由于睾丸发育不良,无法正常生产精子常导致无精子症,无法生育后代。许多夫妇选择收养或使用捐精者的精子生育。近些年来,随着辅助生殖技术的发展,对克氏综合征患者的治疗有了更多的策略,可采用内分泌治疗以及通过获取睾丸精子进行卵母细胞内单精子注射治疗。对克氏综合征生育相关研究进行综述,探讨克氏综合征患者取精年龄、手术方式、内分泌治疗以及遗传风险相关问题。

关键词: 克氏综合征, 男性不育, 临床表现, 睾丸取精, 内分泌治疗

Abstract: The Klinefelter syndrome is the most frequent chromosomal aberration in infertile males. Due to testicular 山东大学学报 (医学版)57卷10期 -马刚,等.克氏综合征的生育相关研究进展 \=-dysplasia, patients are often diagnosed with azoospermatism and cannot have offspring. Many couples choose to adopt or use donor sperms to have babies. In recent years, with the development of assisted reproductive technology, there have been more strategies for the treatment of patients with Klinefelter syndrome. Endocrine therapy and intracytoplasmic sperm injection with sperm acquired from the testicle make it possible for patients to have offspring. In this paper, we will review the research on fertility related to Klinefelter syndrome, and discuss the age of sperm extraction, surgical methods, endocrine therapy and genetic risks in patients with Klinefelter syndrome.

Key words: Klinefelter syndrome, Male infertility, Clinical manifestation, Testicular sperm extraction, Endocrine therapy

中图分类号:

R574

马刚,许超. 克氏综合征的生育相关研究进展[J]. 山东大学学报 (医学版), 2019, 57(10): 67-73.

MA Gang, XU Chao. Research progress on fertility of the Klinefelter syndrome[J]. Journal of Shandong University (Health Sciences), 2019, 57(10): 67-73.

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