您的位置:山东大学 -> 科技期刊社 -> 《山东大学学报(医学版)》

山东大学学报 (医学版) ›› 2019, Vol. 57 ›› Issue (9): 1-4.doi: 10.6040/j.issn.1671-7554.0.2018.1491

• 加速康复外科重点专--专家综述 •    

多模式镇痛在加速康复外科中的作用

江志伟,周嘉晖,成汇   

  1. 江苏省中医院普通外科, 江苏 南京 210029
  • 发布日期:2022-09-27
  • 通讯作者: 江志伟. E-mail:surgery34@163.com
  • 基金资助:
    国家自然科学基金(81500417);江苏省社会发展项目(BE2015687)

Role of multimodal analgesia in enhanced recovery after surgery

JIANG Zhiwei, ZHOU Jiahui, CHENG Hui   

  1. Department of General Surgery, Hospital of Chinese Medicine of Jiangsu Province, Nanjing 210029, Jiangsu, China
  • Published:2022-09-27

摘要: 加速康复外科(ERAS)是以循证医学依据为基础,以减少手术患者的生理及心理的创伤应激为目的,通过外科、麻醉、护理、营养等多学科协作,对围手术期处理的临床路径予以优化,从而减少围手术期应激反应及术后并发症,缩短住院时间,促进患者康复的一种理念。这一优化的临床路径贯穿于住院前、围手术期及出院后,强调要以服务患者为中心。术后疼痛是影响患者恢复的一大因素,不仅影响术后住院天数,同时也会影响患者远期的生活质量。因此,充分止痛是快速康复计划中一个重要环节,也是早期下床活动及早期口服营养的必要前提,能够减少手术应激反应。目前多推荐使用多模式镇痛(MMA)。本文主要讨论外科手术后疼痛管理以及多模式镇痛在术后疼痛管理中的意义,阐述了阿片类药物、非甾体类抗炎药(NSAIDS)、其他辅助镇痛药物及镇痛技术的使用现状。

关键词: 加速康复外科, 围手术期管理, 多模式镇痛, 术后疼痛, 止痛药物

Abstract: Based on evidence-based medicine, with the help of multidisciplinary collaborations such as surgery, anesthesia, nursing, and nutrition, enhanced recovery after surgery(ERAS)optimizes the clinical pathway for perioperative management, in order to reduce perioperative stress response and postoperative complications, relieve the physical and psychological traumatic stress of surgical patients, shorten hospital stay, and promote patients recovery. The optimized clinical pathway involves the whole process from pre-hospital, perioperative, to post-discharge, with an emphasis on serving patients. Postoperative pain is a major factor affecting the recovery of patients, which affects not only the length of hospital stays, but also patients long-term quality of life. Therefore, adequate pain relief is an important part of EARS, a prerequisite for early bed-out activities and early oral nutrition, and a meaningful way to reduce the surgical stress response. Multimodal analgesia(MMA)is currently recommended. This article focuses on postoperative pain management and multimodal analgesia, and reviews the current status of opioids, non-steroidal anti-inflammatory drugs(NSAIDS), other analgesic drugs, and analgesic techniques.

Key words: Enhanced recovery after surgery, Perioperative management, Multimodal analgesia, Postoperative pain, Painkiller

中图分类号: 

  • R61
[1] 江志伟, 李宁, 黎介寿. 快速康复外科的概念及临床意义[J]. 中国实用外科杂志, 2007, 27(2): 131-133.
[2] 江志伟, 黎介寿. 规范化开展加速康复外科几个关键问题[J]. 中国实用外科杂志, 2016,36(1): 44-46.
[3] Tan M, Law LS, Gan TJ. Optimizing pain management to facilitate Enhanced Recovery After Surgery pathways [J]. Can J Anaesth, 2015, 62(2): 203-218.
[4] Baliki MN, Chialvo DR, Geha PY, et al. Chronic pain and the emotional brain: specific brain activity associated with spontaneous fluctuations of intensity of chronic back pain [J]. J Neurosci, 2006, 26(47): 12165-12173.
[5] Dunn LK, Durieux ME, Nemergut EC. Non-opioid analgesics: novel approaches to perioperative analgesia for major spine surgery [J]. Best Pract Res Clin Anaesthesiol, 2016, 30(1): 79-89.
[6] American Society of Anesthesiologists Task Force on Acute Pain Management. Practice guidelines for acute pain management in the perioperative setting: an updated report by the American Society of Anesthesiologists Task Force on Acute Pain Management [J]. Anesthesiology, 2004, 100(6): 1573-1581.
[7] Lovich-Sapola J, Smith CE, Brandt CP. Postoperative pain control [J]. Surg Clin North Am, 2015, 95(2): 301-318.
[8] 陈凛, 陈亚进, 董海龙, 等. 加速康复外科中国专家共识及路径管理指南(2018版)[J]. 中国实用外科杂志, 2018, 38(1): 1-20.
[9] Suleyman H, Demircan B, Karagoz Y. Anti-inflammatory and side effects of cyclooxygenase inhibitors [J]. Pharmacol Rep, 2007, 59(3): 247-258.
[10] Luo Z, Wang H, Huang D. The impact of parecoxib on pain management for laparoscopic cholecystectomy: a meta-analysis of randomized controlled trials[J]. Surg Laparosc Endosc Percutan Tech, 2019, 29(2): 69-74.
[11] Noyes EM, Hao X, Bruce P, et al. Parecoxib relieves pain and has an opioid-sparing effect following major gastrointestinal surgery [J]. Int J Gen Med, 2017, 10: 319-327. doi: 10.2147/IJGM.S143837.
[12] Schjerning OA, Fosbol EL, Lindhardsen J, et al. Duration of treatment with nonsteroidal anti-inflammatory drugs and impact on risk of death and recurrent myocardial infarction in patients with prior myocardial infarction: a nationwide cohort study [J]. Circulation, 2011, 123(20): 2226-2235.
[13] Klein M. Postoperative non-steroidal anti-inflammatory drugs and colorectal anastomotic leakage. NSAIDs and anastomotic leakage [J]. Dan Med J, 2012, 59(3): B4420.
[14] Eren M, Koltka K, Koknel TG, et al. Comparison of analgesic activity of intraarticular lornoxicam, bupivacaine and saline after knee arthroscopy [J]. Agri, 2008, 20(4): 17-22.
[15] Rosero EB, Joshi GP. Preemptive, preventive, multimodal analgesia: what do they really mean? [J]. Plast Reconstr Surg, 2014, 134(4 Suppl 2): 85-93.
[16] Seaton S, Reeves M, Mclean S. Oxycodone as a component of multimodal analgesia for lactating mothers after Caesarean section: relationships between maternal plasma, breast milk and neonatal plasma levels [J]. Aust N Z J Obstet Gynaecol, 2007, 47(3): 181-185.
[17] Bekhit MH. Profile of extended-release oxycodone/acetaminophen for acute pain [J]. J Pain Res, 2015, 8: 719-728. doi: 10.2147/JPR.S73567.
[18] 刘艳君, 王鸾, 张文, 等. 氨酚羟考酮与盐酸曲马多在混合痔术后镇痛中的效果对比观察[J]. 中国临床医生杂志, 2018, 46(2): 211-212.
[19] 戴仁锋, 王伟娟, 刘英. 罗哌卡因局部浸润对全身麻醉下扁桃体摘除术后小儿躁动的影响[J]. 中华全科医学, 2016, 14(5): 736-738.
[20] Wang D, Kong Y, Zhong B, et al. Fast-track surgery improves postoperative recovery in patients with gastric cancer: a randomized comparison with conventional postoperative care[J]. J Gastrointest Surg, 2010, 14(4): 620-627.
[21] Hofstad JK, Winther SB, Rian T, et al. Perioperative local infiltration anesthesia with ropivacaine has no effect on postoperative pain after total hip arthroplasty[J]. Acta Orthop, 2015, 86(6): 654-658.
[22] Li CS, Liu SF, Zhou Y, et al. Effect of dexmedetomidine on perioperative stress and postoperative pain in patients with radical resection of esophageal cancer under combined thoracoscope and laparoscope [J]. Zhonghua Yi Xue Za Zhi, 2018, 98(46): 3778-3783.
[23] Rorarius MG, Mennander S, Suominen P, et al. Gabapentin for the prevention of postoperative pain after vaginal hysterectomy [J]. Pain, 2004, 110(1-2): 175-181.
[24] 张继国, 张颜波, 杨明峰, 等. 加巴喷丁对大鼠内脏炎症痛的镇痛作用及机制初步研究[J]. 中国药理学通报, 2011, 27(11): 1610-1614.
[25] Zakkar M, Frazer S, Hunt I. Is there a role for gabapentin in preventing or treating pain following thoracic surgery? [J]. Interact Cardiovasc Thorac Surg, 2013, 17(4): 716-719.
[26] Kelly DJ, Ahmad M, Brull SJ. Preemptive analgesia I: physiological pathways and pharmacological modalities [J]. Can J Anaesth, 2001, 48(10): 1000-1010.
[27] BELL R F, DAHL J B, MOORE R A, et al. WITHDRAWN: Perioperative ketamine for acute postoperative pain[J]. Cochrane Database Syst Rev, 2015,(7): Cd004603.
[1] 王波,熊颖,倪志福,屈振繁. 加速康复外科理念在1~3岁日间疝手术中的应用[J]. 山东大学学报 (医学版), 2020, 58(12): 92-96.
[2] 李玉杰,韩伟,黄炜,董玉科,李韬,党燕伟,蔡晓清,申晓,龚文丹,许连方. 加速康复外科在44例悬雍垂腭咽成形术中的应用[J]. 山东大学学报 (医学版), 2020, 58(11): 92-97.
[3] 支梦伟,江志伟,戴新娟,王刚,程伟. 加速康复外科指导下胃癌患者围手术期心率变异度的临床观察[J]. 山东大学学报 (医学版), 2020, 58(11): 85-91.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!