山东大学学报 (医学版) ›› 2019, Vol. 57 ›› Issue (2): 70-74.doi: 10.6040/j.issn.1671-7554.0.2018.1132
• • 上一篇
张晓英1*,赵云2*,刘桂香1,王振光3
ZHANG Xiaoying1*, ZHAO Yun2*, LIU Guixiang1, WANG Zhenguang3
摘要： 目的 探讨放射线治疗的分子机制,以更好地指导口腔鳞癌患者的临床放射治疗。 方法 以不同剂量(0、4、8、10 Gy)的放射线照射舌鳞癌Tca8113细胞,采用流式细胞仪检测细胞周期分布及凋亡,并在相差显微镜下观察细胞形态学变化。 结果 流式细胞仪分析结果显示,10 Gy放射线照射明显诱导了Tca8113细胞G2/M期阻滞和细胞凋亡,并且Tca8113细胞经10 Gy放射线照射后细胞形态发生了明显的变化。 结论 放射线照射可导致口腔癌细胞周期阻滞、凋亡和胀亡的形态学变化。
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