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山东大学学报（医学版） ›› 2016, Vol. 54 ›› Issue (5): 84-87.doi: 10.6040/j.issn.1671-7554.0.2016.094

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RbAp48在子宫内膜腺癌中的表达及临床意义

王平1,陈静2,史庆1,傅艺冰1   

  1. 1.山东大学附属省立医院妇科, 山东 济南 250021;2.济南市妇幼保健院妇产科, 山东 济南 250001
  • 收稿日期:2016-01-25 出版日期:2016-05-16 发布日期:2016-05-16
  • 通讯作者: 傅艺冰. E-mail:Fu_yibing@163.com E-mail:Fu_yibing@163.com
  • 基金资助:
    山东省自然科学基金(ZR2014HM008)

RbAp48 expression and its clinical significance in endometrial adenocarcinoma

WANG Ping1, CHEN Jing2, SHI Qing1, FU Yibing1   

  1. 1.Department of Gynecology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China;
    2. Department of Obstetrics and Gynecology, Hospital of Maternal and Child Health, Jinan 250001, Shandong, China
  • Received:2016-01-25 Online:2016-05-16 Published:2016-05-16

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摘要： 目的 探讨RbAp48在子宫内膜腺癌中的表达及临床意义。 方法 收集标本,采用免疫组织化学SP法检测72例正常子宫内膜组织(增生期21例,分泌期27例,绝经期24例)、27例子宫内膜不典型增生、52例不同分化程度的子宫内膜腺癌组织标本中RbAp48蛋白的表达,并分析RbAp48表达与临床病理特征的关系。 结果 子宫内膜腺癌组织中RbAp48的表达高于正常子宫内膜及子宫内膜不典型增生,与增生期无关(P>0.05),与分泌期、绝经期及不典型增生有关(P<0.05);分化程度低的腺癌RbAp48表达比分化程度高的腺癌RbAp48表达高,RbAp48表达与FIGO分期、远处转移、孕激素服用史、肌层浸润深度以及肥胖、糖尿病等有关,与年龄、月经初潮、痛经、体质量指数、盆腔淋巴结转移、淋巴血管间隙受累无关。 结论 RbAp48在正常子宫内膜、子宫内膜不典型增生及子宫内膜腺癌组织中均有表达,腺癌组织中RbAp48表达上调,提示其可能在子宫内膜腺癌中发挥重要作用。

关键词: 子宫内膜腺癌, PcG蛋白, 视网膜母细胞瘤结合蛋白, 视网膜母细胞瘤结合蛋白48

Abstract: Objective To explore RbAp48 expression and its significance in endometrial adenocarcinoma. Methods Specimens were collected from 72 cases of normal endometrium(21 in hyperplasia phase, 27 in secretory phase, 24 in menopause), 27 cases of atypical hyperplasia, and 52 cases of endometrial adenocarcinoma with varying degrees of differentiation. The RbAp48 expression was detected with immunohistochemical method. The relevance between RbAp48 expression and the clinicopathological features of endometrial adenocarcinoma was analyzed. Results The RbAp48 expression was higher in endometrial adenocarcinoma than in normal endometrium and atypical hyperplasia. It was related to the secretory phase, menopause and atypical hyperplasia(P<0.05), but not related to proliferative phase(P>0.05). Poorly differentiated endometrial adenocarcinomas expressed higher RbAp48 than highly differentiated ones. RbAp48 expression was related to FIGO staging, distant metastasis, progestin use, myometrial invasion, obesity and diabetes, but not related to age, menarche age, dysmenorrhea, BMI, metastasis of pelvic lymph node, and lymphvascular space involvement. Conclusion RbAp48 is expressed in normal endometrium, endometrial atypical hyperplasia and endometrial adenocarcinoma tissues. RbAp48 expression is up-regulated in endometrial adenocarcinoma tissues suggesting that it may play an important role in endometrial adenocarcinoma.

Key words: Endomertrial adenocarcinoma, Retinoblastoma-associated protein48, PcG protein, Retinoblastoma

中图分类号: 

  • R737.33
[1] Struhl G. A gene product required for correct initiation of segmental determination in drosophila[J]. Nature,1981, 293(5827):36-41.
[2] Qian YW, Wang YC, Hollingsworth RE, et al. A retinoblastoma-binding protein related to a negative regulator of Ras in yeast[J]. Nature, 1993, 364(6438):648-652.
[3] Alejandra L, Genevieve A. Histone chaperones, a supporting role in the limelight[J]. Biochim Biophys Acta, 2004, 1677(1-3):3-11.
[4] Scuto A, Zhang H, Zhao H, et al. RbAp48 regulates cytoskeletal organization and morphology by increasing K-Ras activity and signaling through mitogen-activated protein kinase[J]. Cancer Res, 2007, 67(21):10317-10324.
[5] Lai A, Lee JM, Yang WM, et al. RBP1 recruits both histone deacetylase-dependent and independent repression activities to retinoblastoma family proteins [J]. Mol Cell Biol, 1999, 19(10):6632-6641.
[6] Tsujii A, Miyamoto Y, Moriyama T, et al. Retinoblastoma-binding protein 4-regulated classical nuclear transport is involved in cellular senescence [J]. J Biol Chem, 2015, 290(49):29375-29388.
[7] Huang HJ, Lee CC, Chen CY. Lead discovery for alzheimer's disease related target protein RbAp48 from traditional chinese medicine[J]. Biomed Res Int, 2014, 2014(2014):764946-764959.
[8] Francesco P, Michele P, Gennaro C, et al. RbAp48 is a target of nuclear factor-κB activity in thyroid cancer [J]. J Clin Endocrinol Metab, 2007, 92(4):1458-1466.
[9] Hai S, Shuang-LX, Cheng L, et al. Genes encoding Pir51,Beclin 1,RbAp48 and aldolase b are up or down-regulated in human primary hepatocellular carcinoma [J]. World J Gastroenterol, 2004, 10(4):509-513.
[10] Fukuoka J, Fujii T, Shih JH, et al. Chromatin remodeling factors and BRM/BRG1 expression as prognostic indicators in non-small cell lung caneer[J]. Clin Cancer Res, 2004, 10(13):4314-4324.
[11] Cui F, Zan X, Li Y, et al. Grifola frondosa glycoprotein GFG-3a arrests S phase, alters proteome, and induces apoptosis in human gastric cancer cells[J]. Nutr Cancer, 2016, 68(2):267-279.
[12] Kong L, Yu XP, Bai XH, et al. RbAp48 is a critical mediator controlling the transforming activity of human papillomavirus type 16 in cervical cancer[J]. J Biol Chem, 2007, 282(36):26381-26391.
[13] Zheng L, Tang W, Wei FH, et al. Radiation-inducible protein RbAp48 contributes to radiosensitivity of cervical cancer cells[J]. Gynecol Oncol, 2013, 130(3):601-608.
[14] 钟晶晶, 杨旭锐, 麦梅清, 等. 下调RbAp48表达可抑制人宫颈癌MS751细胞株的迁移侵袭能力[J]. 南方医科大学学报, 2015, 35(11):1564-1569. ZHONG Jingjing, YANG Xurui, MAI Meiqing, et al. Effect of RbAp48 knockdown on migration and invasion of human cervical cancer cell line MS751 in vitro[J]. Journal of Southern Medical University, 2015, 35(11):1564-1569.
[15] 张雯, 冯婷婷, 郑琳, 等. 重组腺病毒介导的RbAp48基因表达对人宫颈癌细胞生长、增殖的影响[J]. 山东大学学报(医学版), 2014, 52(4):13-17. ZHANG Wen, FENG Tingting, ZHENG Lin, et al. Effects of enhanced expression of RbAp48 mediated by recombinant adenovirus on proliferation and growth of cervical cancer cells[J]. Journal of Shandong University(Health Sciences), 2014, 52(4):13-17.
[16] Torres-Roca JF, Fulp WJ, Caudell JJ, et al. Integration of a radiosensitivity molecular signature into the assessment of local recurrence risk in breast cancer[J]. Int J Radiat Oncol Biol Phys, 2015, 93(3):631-638.
[17] Kitange GJ, Mladek AC, Schroeder MA, et al. Retinoblastoma binding protein 4 modulates temozolomide sensitivity in glioblastoma by regulating DNA repair proteins[J]. Cell Rep, 2016, 14(11):2587-2598.
[18] Amy L, Creekmore, Kjirsten A, et al. The role of retinoblastoma-associated proteins 46 and 48 in estrogen receptor ɑ mediated gene expression[J]. Mol Cell Endocrinol, 2008, 291(1-2):79-86.
[19] Francesco P, Michele P, Gennaro C, et al. RbAp48 is a target of nuclear factor-κB activity in thyroid cancer[J]. J Clin Endocrinol Metab, 2007, 92(4):1458-1466.
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