药物/聚合物微纳纤维的制备与释药性

doi:10.6040/j.issn.1671-7554.0.2015.845

山东大学学报（医学版） ›› 2015, Vol. 53 ›› Issue (12): 33-37.doi: 10.6040/j.issn.1671-7554.0.2015.845

药物/聚合物微纳纤维的制备与释药性

蔡晓青¹, 赵青云², 郭园园¹, 栾玉霞¹

1. 山东大学药学院药物制剂研究所, 山东济南 250012;
2. 即墨市中医院小儿科, 山东即墨 266200

收稿日期:2015-09-07 出版日期:2015-12-10 发布日期:2015-12-10
通讯作者: 栾玉霞。E-mail:yuxialuan@sdu.edu.cn E-mail:yuxialuan@sdu.edu.cn
基金资助:
国家自然科学基金(21373126)

Preparation of drug/polymer fibers in micrometer or nanometer size and their drug release behavior

CAI Xiaoqing¹, ZHAO Qingyun², GUO Yuanyuan¹, LUAN Yuxia¹

1. College of Pharmacy, Shandong University, Jinan 250012, Shandong, China;
2. Hospital of Traditional Chinese Medicine of Jimo, Jimo 266200, Shandong, China

Received:2015-09-07 Online:2015-12-10 Published:2015-12-10

摘要/Abstract

摘要： 目的制备载有牛血清白蛋白(BSA)的聚乙烯醇(PVA)微纳纤维,建立一种新型的药物缓释载体。方法将适量的PVA和BSA混合溶液在液氮下快速冷冻,然后冷冻干燥48 h即得载BSA的PVA纤维。运用扫描电子显微镜(SEM)、X-射线粉末衍射(XRD)、差示扫描量热(DSC)等技术对制备的载药纤维进行表征,并对其体外释药动力学进行研究。结果 BSA成功地包载到PVA中,制得的PVA纤维具有较好的稳定性、较高的载药量和100%的包封率。体外释放实验表明BSA在PVA纤维中具有较好的释放度,其释放曲线符合双相动力学方程。结论载药聚合物纤维能够延缓药物的释放,是一种具有潜在应用价值的新型药物缓释载体。

关键词: 牛血清白蛋白, 聚合物纤维, 聚乙烯醇, 药物释放

Abstract: Objective To prepare the poly(vinyl alcohol) (PVA) fibers loaded with bovine serum albumin (BSA) and to construct a novel drug delivery system. Methods PVA and BSA mixed aqueous solution was quickly frozen using liquid nitrogen then drying for 48 hours, which resulted in the formation of BSA-loaded PVA fibers. The synthesized BSA-loaded PVA fibers were characterized with scanning electron microscopy (SEM), powder X-ray diffraction (XRD) and differential scanning calorimetry (DSC). The drug release behavior of the as-prepared products was also studied. Results The results showed that BSA was successfully incorporated into the biocompatible polymer and the PVA-based fibers had good stability, desired drug loading content and 100% entrapment efficiency. Furthermore, the drug release rate of the as-prepared drug-loaded fibers could be well controlled. The drug release behavior of the BSA-loaded PVA fibers obeyed Biexponential kinetics model with good sustained release. Conclusion The drug release behavior of the micro/nano-fibers demonstrates their promising application in drug delivery system.

Key words: Drug release, Bovine serum albumin, Polymer fiber, Polyvinyl alcohol

中图分类号:

蔡晓青, 赵青云, 郭园园, 栾玉霞. 药物/聚合物微纳纤维的制备与释药性[J]. 山东大学学报（医学版）, 2015, 53(12): 33-37.

CAI Xiaoqing, ZHAO Qingyun, GUO Yuanyuan, LUAN Yuxia. Preparation of drug/polymer fibers in micrometer or nanometer size and their drug release behavior[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(12): 33-37.

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药物/聚合物微纳纤维的制备与释药性

Preparation of drug/polymer fibers in micrometer or nanometer size and their drug release behavior

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