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山东大学学报(医学版) ›› 2015, Vol. 53 ›› Issue (12): 76-80.doi: 10.6040/j.issn.1671-7554.0.2015.417

• 临床医学 • 上一篇    下一篇

DCE-MRI在颈动脉粥样硬化斑块新生血管定量测量中的应用

刘国明1,2, 史浩1, 程海超1   

  1. 1. 山东大学附属千佛山医院影像科, 山东济南 250014;
    2. 山东中医药大学理工学院, 山东济南 250355
  • 收稿日期:2015-04-27 出版日期:2015-12-10 发布日期:2015-12-10
  • 通讯作者: 程海超。E-mail:chc_007@126.com E-mail:chc_007@126.com
  • 基金资助:
    山东省科技发展计划(2011GGB14095)

Application of DCE-MRI in the quantitative measurement of neovascularization in carotid atherosclerotic plaque

LIU Guoming1,2, SHI Hao1, CHENG Haichao1   

  1. 1. Department of Medical Imaging, Qianfoshan Hospital Affiliated to Shandong University, Jinan 250014, Shandong, China;
    2. Institute of Technology, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China
  • Received:2015-04-27 Online:2015-12-10 Published:2015-12-10

摘要: 目的 采用磁共振动态增强扫描(DCE-MRI)测量颈动脉粥样硬化斑块各成分容积传输常数(Ktrans)评估新生血管,为定量测量新生血管及评估斑块稳定性提供依据。方法 颈动脉粥样硬化斑块患者均行MRI平扫及DCE-MRI扫描,根据各成分信号分为纤维组织组、钙化组、近期出血组和脂质核心组,后处理软件评估各组Ktrans值。结果 各组之间有不同的Ktrans值,纤维组织组拥有较高的Ktrans值(0.591/min)、钙化组(0.031/min)、近期出血组(0.115/min)和脂质核心组(0.048/min)拥有较低的Ktrans值。各组之间Ktrans值两两比较,近期出血组和脂质核心组差异无统计学意义(P>0.05),纤维组织组与钙化组、纤维组织组与近期出血组、纤维组织组与脂质核心组、钙化组与近期出血组、钙化组与脂质核心组之间差异有统计学意义(P<0.05)。结论 Ktrans值反映各组渗透性和新生血管含量的不同,可作为定量评估斑块新生血管、评估斑块稳定性的重要依据。

关键词: 定量测量, 新生血管, DCE-MRI, 颈动脉粥样硬化斑块

Abstract: Objective To evaluate neovascularization by measuring the volume transfer constant (Ktrans) of the different components in carotid atherosclerosis plaques after DCE-MRI dynamic contrast-enhanced magnetic resonance imaging, in order to provide evidence to determine plaque stability and quantitative measurement of neovascularization. Methods A total of 41 patients with suspected atherosclerotic plaques in carotid arteries were scanned with MRI and DCE-MRI, and then divided into different groups according to each component signal:fibrosis group, calcification group, recent hemorrhage group and lipid core group. Data of dynamic enhancement were treated with a post processing procedure to evaluate and compare the volume transfer constant (Ktrans) of various components in the plaques. Results There were different Ktrans values in different groups:0.591/min in fibrosis group, 0.031/min in calcification group, 0.115/min in recent hemorrhage group, and 0.048/min in lipid core group. There was no difference between the lipid core and recent hemorrhage groups (P>0.05), but there were differences between the other groups (P<0.05). Conclusion Ktrans value in different components can reflect the different permeability and blood supply. It can be used as an indicator to assess the plaque stability and neovascularization.

Key words: Carotid atherosclerotic plaques, Neovascularization, DCE-MRI, Quantitative measurement

中图分类号: 

  • R445
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