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山东大学学报（医学版） ›› 2016, Vol. 54 ›› Issue (5): 79-83.doi: 10.6040/j.issn.1671-7554.0.2015.1144

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养正消积胶囊联合化疗治疗转移性乳腺癌的临床疗效及安全性

徐志宏1,刘荣凤1,王晓翔1,冯莉1,姚铁柱2,刘红3   

  1. 河北医科大学第四医院 1.肿瘤内科;2.心内科;3.妇瘤科, 河北 石家庄 050011
  • 收稿日期:2015-11-20 出版日期:2016-05-16 发布日期:2016-05-16
  • 通讯作者: 姚铁柱. E-mail:13733315579 @163.com E-mail:13733315579 @163.com

Efficacy and safety of Yangzheng Xiaoji capsule combined with chemotherapy in treating metastatic breast cancer

XU Zhihong1, LIU Rongfeng1, WANG Xiaoxiang1, FENG Li1, YAO Tiezhu2, LIU Hong3   

  1. 1. Department of Oncology;
    2. Department of Cardiology;
    3. Department of Gynecological Tumor, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei, China
  • Received:2015-11-20 Online:2016-05-16 Published:2016-05-16

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摘要： 目的 探讨养正消积胶囊联合化疗治疗转移性乳腺癌的有效性和安全性以及对T淋巴细胞亚群的影响。 方法 将转移性乳腺癌79例患者按随机数字表法分为治疗组(40例)和对照组(39例);对照组给予GT化疗方案治疗,21d/周期,共6个周期;治疗组在对照组基础上口服养正消积胶囊,化疗第1天开始给予,4粒/次,3次/d,连续服用,21d/周期,共6个周期。比较两组临床疗效和不良反应;参照生活质量问卷-乳腺癌模式量表(QLQ-BR23)分析两组生存质量;检测两组血清T 淋巴细胞亚群水平。 结果 治疗组总有效率为55%,明显高于对照组的28.21%(P<0.05);治疗组肝肾功能不全发生率为10%,明显低于对照组的33.33%(P<0.05);治疗后6个月,治疗组患者的体型和未来看法评分均明显高于对照组,而性功能、性乐趣、乳房症状、脱发引起的烦恼、手臂症状以及系统治疗不良反应评分均低于对照组(P<0.01);治疗后3个月,治疗组CD3+、CD4+、CD4+/CD8+水平均明显高于治疗前和对照组同期水平,而CD8+水平明显降低(P<0.01)。 结论 养正消积胶囊联合化疗治疗转移性乳腺癌的疗效确切,安全性高,且可明显改善患者生活质量及提高细胞免疫功能。

关键词: 转移性乳腺癌, 联合化疗, T淋巴细胞亚群, 养正消积胶囊

Abstract: Objective To investigate the efficacy and safety of Yangzheng Xiaoji capsule combined with chemotherapy in the treatment of metastatic breast cancer and its influence on T lymphocyte cell subsets. Methods A total of 79 metastatic breast cancer patients were randomly divided into the treatment group(n=40)and control group(n=39)according to digital table method. The control group was treated with GT chemotherapy, which was a total of 6 courses of treatment with q3w. The treatment group received the same amount of chemotherapy, and Yangzheng Xiaoji capsules, 4 capsules/time, 3 times/day, 21 days/course, for 6 courses of treatment. The clinical efficacy and adverse reactions were compared between the two groups. The survival quality of all patients was analyzed by QLQ-BR23. T sublymphocyte level was detected in both groups. Results The total efficacy rate of the treatment group was 55%, which was superior to that of the control group, 28.21%(P<0.05). Incidence of liver and kidney function deficiency in the treatment group was 10%, which was lower than that of the control group, 33.33%(P<0.05). Six months after treatment, scores of QLQ-BR23 in the treatment group were superior to those of the control group(P<0.01). Three months after treatment, levels of CD3+, CD4+ and CD4+/CD8+ of the treatment group were higher than those of the control group, while CD8+ was lower, with statistically significant difference(P<0.01). Conclusion Yangzheng 山 东 大 学 学 报 (医 学 版)54卷5期 -徐志宏,等.养正消积胶囊联合化疗治疗转移性乳腺癌的临床疗效及安全性 \=-Xiaoji capsule combined with chemotherapy in treating metastatic breast cancer can increase efficacy, decrease adverse reactions, and improve quality of life and cellular immune function.

Key words: Yangzheng Xiaoji capsule, Metastatic breast cancer, Combined chemotherapy, T lymphocyte cell subsets

中图分类号: 

  • R737.9
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