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山东大学学报(医学版) ›› 2015, Vol. 53 ›› Issue (1): 58-62.doi: 10.6040/j.issn.1671-7554.0.2014.551

• 临床医学 • 上一篇    下一篇

垂体柄阻断综合征患儿垂体核磁共振表现与功能损伤的相关性

王凤雪, 王倩, 李桂梅, 胡艳艳, 王增敏   

  1. 山东大学附属省立医院儿科, 山东 济南 250014
  • 收稿日期:2014-08-25 修回日期:2014-11-04 发布日期:2015-01-10
  • 通讯作者: 李桂梅。E-mail:lgmusa05@yahoo.com E-mail:lgmusa05@yahoo.com
  • 基金资助:
    山东省科委立项课题(2013GSF11817)

Correlation between pituitary MRI and endocrine functions in patients with pituitary stalk interruption syndrome

WANG Fengxue, WANG Qian, LI Guimei, HU Yanyan, WANG Zengmin   

  1. Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250014, Shandong, China
  • Received:2014-08-25 Revised:2014-11-04 Published:2015-01-10

摘要: 目的 探讨垂体强化核磁共振(MRI)对垂体柄阻断综合征(PSIS)的诊断价值并分析垂体MRI表现与垂体-靶腺功能损伤的相关性。方法 选取PSIS患儿64例(PSIS组),同时选取正常儿童及青少年60例(对照组)。根据垂体MRI表现将PSIS组分为部分性垂体柄阻断(pPSIS)组和完全性垂体柄阻断(cPSIS)组。检测相关激素水平,分析MRI表现与缺乏的激素种类数目及严重程度的相关性。结果 PSIS组垂体核磁共振表现与功能损伤呈正相关。比较垂体-靶腺激素,cPSIS组缺乏的激素种类数目及严重程度均显著高于pPSIS组(P<0.01)。PSIS组男性(24例,年龄均大于15岁)性激素水平显著低于对照组(P<0.05),cPSIS组男性睾酮水平显著低于pPSIS组(P<0.01),其余性激素水平无显著差异。结论 下丘脑-垂体区强化MRI可显示垂体柄的受损程度,可用于评估PSIS患儿垂体功能。

关键词: 生长激素缺乏症, 强化核磁共振, 垂体激素缺乏, 部分性垂体柄阻断综合征, 完全性垂体柄阻断综合征

Abstract: Objective To investigate the correlation between magnetic resonance imaging (MRI) and levels of pituitary-target hormones in patients with pituitary stalk interruption syndrome (PSIS). Methods A total of 64 patients with PSIS were divided into two groups according to the appearance of pituitary stalk: partial PSIS group (group pPSIS) and complete PSIS group (group cPSIS). Meanwhile, 60 healthy children and teenagers were recruited as controls. Pituitary functions were measured and compared between PSIS patients and age-matched controls. Results There was significantly small anterior pituitary in cPSIS group (P<0.01). The incidence of ectopic posterior pituitary was significantly higher in cPSIS group than in pPSIS group (P<0.01). In addition, serum levels of growth hormone (GH), pituitary-thyroid hormones, and pituitary-adrenal hormones were significantly lower in the two PSIS groups than in the controls, and those were lower in cPSIS group than in pPSIS group (P<0.01). The levels of pituitary-gonadal hormones were not significantly different in the two PSIS groups, except for testosterone (T, P<0.05). Conclusion Grades of MRI can predict occurrence and severity of PSIS, which are also correlated with the levels of the pituitary-target hormone deficiencies.

Key words: Magnetic resonance imaging, Pituitary hormone deficiency, Growth hormone deficiency, Complete pituitary stalk interruption syndrome, Partial pituitary stalk interruption syndrome

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