JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2010, Vol. 48 ›› Issue (2): 109-112.

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Expression and significance of PTEN, E-cd and MMP-9 in human glioma

ZHANG Junpu, XU Wen, LIU Xianghui   

  1. Department of Neurosurgery, Dezhou People′s Hospital, Dezhou 253014, Shandong,  China
  • Received:2009-10-21 Online:2010-02-16 Published:2010-02-16

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Abstract:

Objective  To investigate expressions of tumor suppressor PTEN, E-cadherin(E-cd)and matrix metalloproteinase-9(MMP-9)in human glioma and to elucidate its clinical significance. Method  Immunohistochemical staining was used to detect  expressions of PTEN, E-cd and MMP-9 in 50 cases of human glioma and 11 of normal brain tissues. Results  In normal brain tissues, the positive rates of E-cd and PTEN were 100％ and of MMP-9 was 14％. The positive rate of PTEN in glioma was lower than that in the control group(P<0.05), and the positive rate of PTEN in low grade glioma was higher than that in high grade glioma (75％ vs. 38％, P<0.05). The positive rate of E-cd in glioma was lower than that in the control group(P<0.05), but there was no significant difference between low grade glioma and high grade glioma (42％ vs. 23％, P>0.05). The positive rate of MMP-9 in glioma was higher than that in the control group(P<0.05), and there was significant difference between low grade glioma and high grade glioma (33％ vs. 62％, P<0.05). Conclusion  PTEN, E-cd and MMP-9 play important roles in the biological behavior of glioma, which may be related to invasiveness.

Key words: Glioma; Suppressor PTEN; E-cadherin; Matrix metallo proteinase-9

CLC Number: 

  • R737.9
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