Abstract:

Objective   To study the metabolic features of alkaline phosphatase(Alp), calcium(Ca) and phosphorus(P) in premature infants and provide a basis for rational supplement of Ca and P. Methods  120 premature infants were enrolled as the observation group and 60 full term healthy infants in the same period were enrolled as the control group. The levels of Alp, Ca and P in the serum within 72 hours after birth were tested. Data were analyzed not only between the observation group and the control group, but also within the observation group on the basis of different genders, birth weights and gestational ages. Results  ① The levels of serum Alp, P in  the  observation group were higher than that in the control group, while the level of serum Ca was lower (P＜0.01); ②　The difference were not statistically significant in the levels of Alp, P and Ca based on different genders in the observation group(P＞0.05); the levels of serum Alp, P in the observation group decreased with increasing birth weight r=-0.83, -0.65, P＜0.01）, while the level of Ca increased(r=0.67, P＜0.05）; the levels of serum Alp, P in the observation group were negatively correlated with gestational age（r=-0.80,-0.64, P＜0.01）, but the level of Ca was positively correlated（r=0.52, P＜0.01）. Conclusions  Birth weight and gestational age were important factors affecting the levels of serum Alp, Ca and P in premature infants. Ca and P could be appended rationally by detecting Alp, Ca and P in the serum of preterm infants so as to prevent metabolic bone disease.

Key words: Premature； Alkaline phosphatase; Calcium; Phosphorus; Metabolic bone disease