JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2010, Vol. 48 ›› Issue (2): 105-.

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Dynamic observation of serum interleukin6 and matrix metalloproteinase-9 in patients with cerebral hemorrhage after minimally invasive hematoma aspiration

YU Zhaoang, CUI Yuanxiao, ZHANG Qinghua, TIAN Min, TANG Qianqian   

  1. Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China
  • Received:2009-10-26 Online:2010-02-16 Published:2010-02-16

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Abstract:

Objective  To study the dynamic changes of serum interleukin -6 and matrix metalloproteinase -9 in patients with cerebral hemorrhage after minimally invasive surgery(MIS)， and to assess the efficacy of minimally invasive surgery. Methods  Blood samples were obtained on the admission day and  days 2, 7 and 14 after the onset from 30 patients with MIS and 30 patients with non-minimally invasive surgery(NMIS). Serum IL-6 and MMP-9 were detected by enzyme linked immunosorbent assay(ELISA). Results  Serum MMP-9 and IL-6 levels increased within 6h after onset in patients with cerebral hemorrhage. Both groups reached the peak on day 2, but the control group increased more significantly. The IL-6 and MMP-9 levels were decreased significantly on days 7 and 14 in the operation group. The results also showed that the clinical efficacy in the minimally invasive group was better than that in the control group. Conclusion  Minimally invasive surgery can decrease the serum levels of IL-6 and MMP-9. Serum IL-6 and MMP-9 can be used as the biomarkers for prognosis and outcome in patients with MIS.

Key words: Cerebral hemorrhage； Interleukin-6； Gelatinase B； Minimally invasive hematoma aspiration

CLC Number: 

  • R743.34
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[2] CUI Yuan-xiao1， TANG Qian-qian1， GUO Zhang-yu1, SHANG Xiao1, ZHANG Qing-hua1， FENG Xiao-ya2. Experimental research of apoptosis in rat tissue cells surrounding
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[3] TANG Qian-qian1， YUAN Qian2, CUI Yuan-xiao1， ZHANG Qing-hua1， GUO Zhang-yu1. Effects of heat shock protein 70 on expressions of the Bcl-2 and Bax proteins in nerve cells of rats with intracerebral hemorrhage [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(11): 40-.
[4] TIAN Min, YUAN Qian, CUI Yuan-xiao, ZHANG Qing-hua, TANG Qian-qian . Dynamic fluctuation of fibrinolytic activity in patients withmini-invasive hematoma aspiration [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(10): 73-76.
[5] . Effect of miniinvasive hematoma aspiration on the content of glial

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