合并Whipple三联征的多发性内分泌腺瘤1型——附2例报道

doi:10.6040/j.issn.1671-7554.0.2015.258

摘要/Abstract

摘要： 目的分析2例以Whipple三联征为首发症状的多发性内分泌腺瘤1型(MEN1)的CT及MRI表现,以期提高对该病的认识。方法 2例MEN1型病例均采用实验室检查、超声、CT及MRI检查,行手术探查和胰岛素瘤病灶切除,并与病理结果对照。结果术中发现2例患者共11个胰岛素瘤病灶,CT检出4个(36%),MRI检出6个(55%),未检出的病灶直径均低于0.5 cm。病变发生于胰头、胰体、胰尾部分别为2、4、5个。1例合并垂体微腺瘤,1例合并单侧肾上腺瘤及双侧甲状旁腺增生。结论 CT及MRI有助于检出MEN1型患者的多个胰岛素瘤病灶,但对于微小病灶的检出仍有困难。

关键词: 胰岛素瘤, CT, 多发性内分泌腺瘤1型, MRI

Abstract: Objective To analyze the CT and MRI features of two cases of multiple endocrine neoplasia type 1(MEN1), and improve the knowledge to it. Methods Lab examination, ultrsonography, CT and MRI enhancement scan were performed in two cases of MEN1 patients. Image findings were compared with the surgery of insulinoma resection and pathology. Results Eleven foci were found in operation. Four and six nodules were detected by CT and MRI, respectively. The nodules smaller than 0.5 cm were not found. Two, four and five lesions located at the head, body and tail of pancreas, respectively. One patient had pituitary microadenoma, the other had unilateral adrenal adenoma and bilateral parathyroid hyperplasia. Conclusion CT and MRI are valuable tools in the detection of multiple lesions of insulinoma in MEN1 patients but it is rather hard to determine the very small nodules.

Key words: Multiple endocrine neoplasia type 1, Insulinoma, MRI, CT

中图分类号:

R445.2

李笃民,王茜,李传福,王青. 合并Whipple三联征的多发性内分泌腺瘤1型——附2例报道[J]. 山东大学学报（医学版）, 2016, 54(1): 62-66.

LI Dumin, WANG Qian, LI Chuanfu, WANG Qing. Two cases of multpile endoncrine neoplasia type 1 with Whipple syndrome[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(1): 62-66.

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