雷替曲塞联合奥沙利铂或伊立替康二线治疗晚期结直肠癌的临床观察

摘要/Abstract

摘要： 目的观察雷替曲塞联合奥沙利铂或伊立替康二线治疗晚期结直肠癌的疗效及安全性。方法 25例结直肠癌患者,17 例给予雷替曲塞 3 mg/m² 静脉滴注15 min,奥沙利铂 130 mg/ m²静脉滴注 2 h;8 例给予雷替曲塞 2.6 mg/ m² 静脉滴注 15 min,伊立替康 300 mg/m² 静脉滴注90 min。均3周为1个治疗周期。观察患者近期疗效,不良反应和生存状况。结果总有效率为24 %(6/25),疾病控制率为68 %(17/25);中位无疾病进展时间5.3 个月;最常见的不良反应主要为白细胞减少(64%)、中性粒细胞减少(52%)、乏力(56%)、食欲减退(48%)和肝功能异常(56%),多为Ⅰ～Ⅱ级。结论雷替曲塞联合奥沙利铂或伊立替康在晚期结直肠癌的二线化疗中疗效确切,耐受性好,值得临床借鉴。

关键词: 二线化疗, 职业, 伊立替康, 基础教学, 安全教育, 雷替曲塞, 高职护理学, 奥沙利铂, 结直肠癌

Abstract: Objective To observer the clinical effects of raltitrexed combined with oxaliplatin or irinotecan as second-line chemotherapy for advanced colorectal cancer. Methods Out of twenty five patients enrolled, seventeen patients received raltitrexed 3 mg/m² as a 15-min infusion, followed by oxaliplatin 130 mg/m² as a 2-hour infusion, and nine patients received raltitrexed 2.6 mg/m² as a 15-min infusion, followed by irinotecan 300 mg/m² as a 90-min infusion. Results The overall response rate of raltitrexed combined with oxaliplatin or irinotecan was 24%(6/25), and disease control rate was 68%(17/25). The median time of progression-free survival was 5.3 months. The most common adverse reactions were leucopenia/neutropenia decline, fatigue, appetite decrease and hepatic disorders, with incidence rates of 64%, 52%, 56%, 48%, and 56%, respectively, which mainly be graded Ⅰ to Ⅱ. Conclusion Raltitrexed combined with oxaliplatin or irinotecan as second-line chemotherapy has a high efficacy with acceptable tolerability, therefore being worth recommending for advanced colorectal cancer.

Key words: second-line chemotherapy, raltitrexed, oxaliplatin, irinotecan, colorectal cancer

中图分类号:

R735.3

李剑萍, 缪宇锋, 陈平, 陈苏蓉, 刘红旗. 雷替曲塞联合奥沙利铂或伊立替康二线治疗晚期结直肠癌的临床观察[J]. 山东大学学报（医学版）, 2014, 52(S1): 49-50.

LI Jian-ping, MIAO Yu-feng, CHEN Ping, CHEN Su-rong, LIU Hongqi. Use of raltitrexed combined with oxaliplatin or irinotecan as second-line chemotherapy for advanced colorectal cancer[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(S1): 49-50.

参考文献

[1] Slatter J G,Schaaf L J,Sams J P,et al.Pharmacokinetics,metabolism,and excretion of irinotecan (CPT-11) following iv infusion of [14C] CPT-11 in cancer patients[J].Drug Metab and Dispos,2000,28(4): 423-433.
[2] 张文,许立功.晚期结直肠癌的化疗进展[J].中国癌症杂志,2004,14(4): 378-382.
[3] Seitz J F,Bennouna J,Paillot B,et al.Multicenter non-randomized phase II study of raltitrexed (Tomudex) and oxaliplatin in non-pretreated metastatic colorectal cancer patients[J].Ann of Oncol,2002,13(7): 1072-1079.
[4] Scheithauer W,Kornek G V,Schuell B,et al.Second-line treatment with oxaliplatin+ raltitrexed in patients with advanced colorectal cancer failing fluoropyrimidine/leucovorin-based chemotherapy[J].Annals of oncology,2001,12(5): 709-714.
[5] Therasse P,Arbuck S G,Eisenhauer E A,et al.New guidelines to evaluate the response to treatment in solid tumors[J].J Natl Cancer Inst,2000,92(3): 205-216.
[6] 王佳蕾,李进,秦叔逵,等.雷替曲塞或氟尿嘧啶/亚叶酸钙联合奥沙利铂治疗局部晚期或复发转移性结直肠癌的随机对照多中心 Ⅲ 期临床试验[J].临床肿瘤学杂志,2012,17(1): 6-11.
[7] 谢达成,李宁,王静珏,等.雷替曲塞联合伊立替康 2 周方案对比 FOLFIRI 方案二线治疗晚期结直肠癌的疗效观察[J].临床肿瘤学杂志,2013,18(2): 140-143.

相关文章 15

[1]	李梓绮,魏闫若雪,刘晓晗,刘春铖,赵然,刘玉昆. 长链非编码RNA HEATR3反义RNA 1参与结直肠癌发生发展的功能及其临床意义[J]. 山东大学学报 (医学版), 2025, 63(9): 108-115.
[2]	杜雪,李春霞,刘云霞,张涛. 基于MFPC-Cox的结直肠癌患者预后动态预测模型[J]. 山东大学学报 (医学版), 2025, 63(5): 101-110.
[3]	王刚,徐鹏演,赵旭安,王海锋,葛苗苗,潘华峰,江志伟. ω-3多不饱和脂肪酸对腹腔镜结直肠癌术后迷走神经和肠功能恢复的影响[J]. 山东大学学报 (医学版), 2025, 63(2): 36-42.
[4]	崔倩倩,李金鹏,吴豫丹,侯志平,孙玮螺,崔盼盼,何培元. 粪便miRNA对结直肠进展期腺瘤无创筛查的临床价值[J]. 山东大学学报 (医学版), 2025, 63(2): 43-50.
[5]	常宇,胡云峰,王会丰,郭静,张跳,郝雅琴,刘雨. 阑尾切除术与结直肠癌发病风险关联的孟德尔随机化研究[J]. 山东大学学报 (医学版), 2025, 63(2): 77-83.
[6]	俞静,王刚,王烨,邵明月,潘华峰,葛苗苗,王海锋,江志伟. 基于I-FEED评分系统观察益气导滞方对结直肠癌术后胃肠功能恢复的影响[J]. 山东大学学报 (医学版), 2025, 63(12): 35-43.
[7]	王潇,孔文茹,崔伟亮,王姝麒. 羊角棉总生物碱增强氟尿嘧啶对结直肠癌化疗敏感性[J]. 山东大学学报 (医学版), 2024, 62(6): 30-37.
[8]	魏闫若雪,李梓绮,刘春铖,刘晓晗,赵然,刘玉昆. 结直肠癌中SP1的瘤内异质性表达及其临床意义[J]. 山东大学学报 (医学版), 2024, 62(5): 89-94.
[9]	刘春铖,刘晓晗,魏闫若雪,李梓绮,刘玉昆,赵然. 结直肠癌中含溴结构域蛋白9的亚细胞定位模式及其临床意义[J]. 山东大学学报 (医学版), 2024, 62(4): 24-30.
[10]	于丽,王弋嘉,杨勇,刘学焕,万雪花,包翠萍,苗蓓亮,李斯琪,李静,刘筠. 基于光学表面波技术探究具核梭杆菌介导的自噬与细胞折射率的关系[J]. 山东大学学报 (医学版), 2024, 62(10): 87-97.
[11]	术洪婷,任敏敏,王慧,孙相洁,封丹珺. 护士职业压力与生活质量的关系:一个有调节的中介模型[J]. 山东大学学报 (医学版), 2024, 62(1): 89-94.
[12]	董雅琪,王新慧,赵颖慧,王传新. 血清外泌体LINC02163作为结直肠癌远处转移标志物的临床价值[J]. 山东大学学报 (医学版), 2023, 61(9): 19-28.
[13]	蒋莉莉,吴柳柳,徐新阳,张晓荣,曹枫林,辛育恒. 疾控人员职业倦怠潜在剖面分析及与工作特征的关系[J]. 山东大学学报 (医学版), 2023, 61(2): 102-109.
[14]	高怡明,赵香玉,王清,周淼,厉萍. 手术室护士心理资本对职业倦怠的影响:工作沉浸的中介作用及性别调节[J]. 山东大学学报 (医学版), 2023, 61(1): 74-79.
[15]	卢燕娥,王娟,张烜,毛芳香,孙萌,曹枫林. 护士遭受职场心理暴力的潜在类别分析及其与职业倦怠的关系[J]. 山东大学学报 (医学版), 2022, 60(5): 118-124.

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed