您的位置:山东大学 -> 科技期刊社 -> 《山东大学学报(医学版)》

山东大学学报 (医学版) ›› 2018, Vol. 56 ›› Issue (5): 8-12.doi: 10.6040/j.issn.1671-7554.0.2018.431

• • 上一篇    下一篇

抗苗勒氏管激素在妇科肿瘤领域的应用前景

曹冬焱,毕晓宁,沈铿   

  1. 中国医学科学院北京协和医学院 北京协和医院妇产科, 北京 100730
  • 收稿日期:2018-04-09 发布日期:2022-09-27
  • 通讯作者: 曹冬焱. E-mail:caodongyan@pumch.cn

Application of anti-Mullerian hormone in gynecologic oncology

CAO Dongyan, BI Xiaoning, SHEN Keng   

  1. Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &
    Peking Union Medical College, Beijing 100730, China
  • Received:2018-04-09 Published:2022-09-27

摘要: 作为评估卵巢储备功能的指标,抗苗勒氏管激素(AMH)在生殖内分泌领域已得到广泛应用。随着肿瘤治疗的发展以及人们对肿瘤生殖学的重视,妇科肿瘤患者的卵巢功能与生育问题引起了广泛关注。AMH作为月经周期中相对恒定的指标,在监测妇科肿瘤复发、评估妇科肿瘤手术损伤以及指导恶性肿瘤患者保留生育功能等方面起着至关重要的作用。

关键词: 抗苗勒氏管激素, 妇科肿瘤, 卵巢储备功能, 肿瘤标志物, 手术损伤, 保留生育功能

Abstract: Anti-Mullerian hormone has been widely used as a marker of ovarian reserve in the field of reproductive endocrinology. With the development of oncology treatment and oncofertility, ovarian function and fertility problems in gynecological oncological patients have drawn widespread attention. As a relatively constant marker in the menstrual cycle, AMH plays a crucial role in monitoring the recurrence of gynecological tumors, assessing surgical injuries, and guiding fertility preservation treatment for gynecologic malignancies.

Key words: Anti-Müllerian hormone, Gynecologic oncology, Ovarian reserve, Tumor marker, Surgical injury, Fertility preservation

中图分类号: 

  • R737.3
[1] Cate RL, Mattaliano RJ, Hession C, et al. Isolation of the bovine and human genes for Mullerian inhibiting substance and expression of the human gene in animal cells[J]. Cell, 1986, 45(5): 685-698.
[2] Kelsey TW, Anderson RA, Wright P, et al. Data-driven assessment of the human ovarian reserve[J]. Mol Hum Reprod, 2012, 18(2): 79-87.
[3] Jeppesen JV, Anderson RA, Kelsey TW, et al. Which follicles make the most anti-Mullerian hormone in humans? Evidence for an abrupt decline in AMH production at the time of follicle selection[J]. Mol Hum Reprod, 2013, 19(8): 519-527.
[4] Dewailly D, Andersen CY, Balen A, et al. The physiology and clinical utility of anti-Mullerian hormone in women[J]. Hum Reprod Update, 2014, 20(3): 370-385.
[5] Lindhardt JM, Hagen CP, Johannsen TH, et al. Anti-mullerian hormone and its clinical use in pediatrics with special emphasis on disorders of sex development[J]. Int J Endocrinol, 2013, 2013:198698.
[6] Huang H, Wang C, Tian Q. Gonadal tumour risk in 292 phenotypic female patients with disorders of sex development containing Y chromosome or Y-derived sequence[J]. Clin Endocrinol(Oxf), 2017, 86(4): 621-627.
[7] Karkanaki A, Vosnakis C, Panidis D. The clinical significance of anti-Mullerian hormone evaluation in gynecological endocrinology[J]. Hormones(Athens), 2011, 10(2): 95-103.
[8] Farkkila A, Koskela S, Bryk S, et al. The clinical utility of serum anti-Mullerian hormone in the follow-up of ovarian adult-type granulosa cell tumors—a comparative study with inhibin B[J]. Int J Cancer, 2015, 137(7): 1661-1671.
[9] Rey RA, Lhomme C, Marcillac I, et al. Antimullerian hormone as a serum marker of granulosa cell tumors of the ovary: comparative study with serum alpha-inhibin and estradiol[J]. Am J Obstet Gynecol, 1996, 174(3): 958-965.
[10] Haltia UM, Hallamaa M, Tapper J, et al. Roles of human epididymis protein 4, carbohydrate antigen 125, inhibin B and anti-Mullerian hormone in the differential diagnosis and follow-up of ovarian granulosa cell tumors[J]. Gynecol Oncol, 2017, 144(1): 83-89.
[11] McLucas B, Voorhees WD 3rd, Snyder SA. Anti-Mullerian hormone levels before and after uterine artery embolization[J]. Minim Invasive Ther Allied Technol, 2018, 27(3):186-190.
[12] Wang HY, Quan S, Zhang RL, et al. Comparison of serum anti-Mullerian hormone levels following hysterectomy and myomectomy for benign gynaecological conditions[J]. Eur J Obstet Gynecol Reprod Biol, 2013, 171(2): 368-371.
[13] Yuan H, Wang C, Wang D, et al. Comparing the effect of laparoscopic supracervical and total hysterectomy for uterine fibroids on ovarian reserve by assessing serum anti-mullerian hormone levels: a prospective cohort study[J]. J Minim Invasive Gynecol, 2015, 22(4): 637-641.
[14] Moorman PG, Myers ER, Schildkraut JM, et al. Effect of hysterectomy with ovarian preservation on ovarian function[J]. Obstet Gynecol, 2011, 118(6): 1271-1279.
[15] Trabuco EC, Moorman PG, Algeciras-Schimnich A, et al. Association of ovary-sparing hysterectomy with ovarian reserve[J]. Obstet Gynecol, 2016, 127(5): 819-827.
[16] Song T, Kim MK, Kim ML, et al. Impact of opportunistic salpingectomy on anti-Mullerian hormone in patients undergoing laparoscopic hysterectomy: a multicentre randomised controlled trial[J]. BJOG, 2017, 124(2): 314-320.
[17] Sahin C, Taylan E, Akdemir A, et al. The impact of salpingectomy and single-dose systemic methotrexate treatments on ovarian reserve in ectopic pregnancy[J]. Eur J Obstet Gynecol Reprod Biol, 2016, 205: 150-152.
[18] Salihoglu KN, Dilbaz B, Cirik DA, et al. Short-term impact of laparoscopic cystectomy on ovarian reserve tests in bilateral and unilateral endometriotic and nonendometriotic cysts[J]. J Minim Invasive Gynecol, 2016, 23(5): 719-725.
[19] Asgari Z, Rouholamin S, Hosseini R, et al. Comparing ovarian reserve after laparoscopic excision of endometriotic cysts and hemostasis achieved either by bipolar coagulation or suturing: a randomized clinical trial[J]. Arch Gynecol Obstet, 2016, 293(5): 1015-1022.
[20] Vignali M, Mabrouk M, Ciocca E, et al. Surgical excision of ovarian endometriomas: does it truly impair ovarian reserve? Long term anti-Mullerian hormone(AMH)changes after surgery[J]. J Obstet Gynaecol Res, 2015, 41(11): 1773-1778.
[21] Ferrero S, Venturini PL, Gillott DJ, et al. Hemostasis by bipolar coagulation versus suture after surgical stripping of bilateral ovarian endometriomas: a randomized controlled trial[J]. J Minim Invasive Gynecol, 2012, 19(6): 722-730.
[22] Giampaolino P, Bifulco G, Di Spiezio Sardo A, et al. Endometrioma size is a relevant factor in selection of the most appropriate surgical technique: a prospective randomized preliminary study[J]. Eur J Obstet Gynecol Reprod Biol, 2015, 195: 88-93.
[23] Green DM, Nolan VG, Kawashima T, et al. Decreased fertility among female childhood cancer survivors who received 22-27 Gy hypothalamic/pituitary irradiation: a report from the Childhood Cancer Survivor Study[J]. Fertil Steril, 2011, 95(6): 1922-1927.
[24] Barton SE, Najita JS, Ginsburg ES, et al. Infertility, infertility treatment, and achievement of pregnancy in female survivors of childhood cancer: a report from the Childhood Cancer Survivor Study cohort[J]. Lancet Oncol, 2013, 14(9): 873-881.
[25] Bath LE, Wallace WH, Shaw MP, et al. Depletion of ovarian reserve in young women after treatment for cancer in childhood: detection by anti-Mullerian hormone, inhibin B and ovarian ultrasound[J]. Hum Reprod, 2003, 18(11): 2368-2374.
[26] Petrek JA, Naughton MJ, Case LD, et al. Incidence, time course, and determinants of menstrual bleeding after breast cancer treatment: a prospective study[J]. J Clin Oncol, 2006, 24(7): 1045-1051.
[27] Morgan S, Anderson RA, Gourley C, et al. How do chemotherapeutic agents damage the ovary?[J]. Hum Reprod Update, 2012, 18(5): 525-535.
[28] Anderson RA, Themmen AP, Al-Qahtani A, et al. The effects of chemotherapy and long-term gonadotrophin suppression on the ovarian reserve in premenopausal women with breast cancer[J]. Hum Reprod, 2006, 21(10): 2583-2592.
[29] Dillon KE, Sammel MD, Prewitt M, et al. Pretreatment antimullerian hormone levels determine rate of posttherapy ovarian reserve recovery: acute changes in ovarian reserve during and after chemotherapy[J]. Fertil Steril, 2013, 99(2): 477-483.
[30] Decanter C, Morschhauser F, Pigny P, et al. Anti-Mullerian hormone follow-up in young women treated by chemotherapy for lymphoma: preliminary results[J]. Reprod Biomed Online, 2010, 20(2): 280-285.
[31] Bi X, Zhang J, Cao D, et al. Anti-Mullerian hormone levels in patients with gestational trophoblastic neoplasia treated with different chemotherapy regimens: a prospective cohort study[J]. Oncotarget, 2017, 8(69): 113920-113927.
[32] Rosendahl M, Andersen CY, la Cour Freiesleben N, et al. Dynamics and mechanisms of chemotherapy-induced ovarian follicular depletion in women of fertile age[J]. Fertil Steril, 2010, 94(1): 156-166.
[33] Anderson RA, Cameron DA. Pretreatment serum anti-mullerian hormone predicts long-term ovarian function and bone mass after chemotherapy for early breast cancer[J]. J Clin Endocrinol Metab, 2011, 96(5): 1336-1343.
[34] Anderson RA, Rosendahl M, Kelsey TW, et al. Pretreatment anti-Mullerian hormone predicts for loss of ovarian function after chemotherapy for early breast cancer[J]. Eur J Cancer, 2013, 49(16): 3404-3411.
[35] Elgindy E, Sibai H, Abdelghani A, et al. Protecting ovaries during chemotherapy through gonad suppression: a systematic review and meta-analysis[J]. Obstet Gynecol, 2015, 126(1): 187-195.
[36] Muraji M, Sudo T, Iwasaki S, et al. The effect of abdominal radical trachelectomy on ovarian reserve: serial changes in serum anti-mullerian hormone levels[J]. J Cancer, 2012, 3: 191-195.
[37] Naasan M, Harrity C, Rajab H, et al. Patients with cancer at the margins of reproductive age had reduced levels of anti-Mullerian hormone compared with patients experiencing infertility[J]. Int J Gynaecol Obstet, 2016, 133(2): 226-229.
[1] 赵汉卿,周新睿,李子建,唐兴. 循环肿瘤细胞联合血清学检测在非小细胞肺癌中的应用[J]. 山东大学学报 (医学版), 2025, 63(5): 79-85.
[2] 杜雪,李春霞,刘云霞,张涛. 基于MFPC-Cox的结直肠癌患者预后动态预测模型[J]. 山东大学学报 (医学版), 2025, 63(5): 101-110.
[3] 刘昶,王倩男,张悦,陈忠绍,褚然,姚舒. 卵巢交界性肿瘤保留生育功能术后肿瘤预后及妊娠结局[J]. 山东大学学报 (医学版), 2023, 61(8): 61-66.
[4] 吴磊丽,蔡华丽,孙德胜,魏蔚霞. 超声引导穿刺硬化术联合地诺孕素治疗卵巢子宫内膜异位囊肿的疗效[J]. 山东大学学报 (医学版), 2023, 61(6): 65-69.
[5] 鹿群,赵璐璐. 子宫内膜癌、子宫内膜非典型增生保留生育功能后助孕策略[J]. 山东大学学报 (医学版), 2022, 60(9): 35-41.
[6] 王稳,董绍华,田翔宇,崔秀娟. 盆腹腔多发脾种植误诊为妇科肿瘤1例[J]. 山东大学学报 (医学版), 2020, 1(9): 116-118.
[7] 官燕飞,陈志强,袁春雷,彭建明,米贤军,刘君,陈昂,袁斌,刘子成. 外周血循环肿瘤细胞、糖类抗原153、糖类抗原125、癌胚抗原检测对105例乳腺导管原位癌或伴微小浸润癌的诊断价值[J]. 山东大学学报 (医学版), 2020, 58(2): 72-78.
[8] 胡佳林,吕家驹,谈月清,管明德,毛昌琳,丁森泰. 睾丸肿瘤86例临床分析[J]. 山东大学学报 (医学版), 2019, 57(4): 77-83.
[9] 杨佳欣,沈铿,王遥. 妇科恶性肿瘤保留生育功能治疗的现状与展望[J]. 山东大学学报 (医学版), 2018, 56(5): 1-7.
[10] 张颖,杨佳欣,曹冬焱,俞梅,沈铿,黄惠芳,潘凌亚,吴鸣,郎景和,游燕. 早期上皮性卵巢癌保留生育功能手术患者预后与妊娠状况的影响因素[J]. 山东大学学报 (医学版), 2018, 56(5): 13-17.
[11] 俞梅,杨佳欣,曹冬焱,王遥,沈铿. 早期子宫内膜癌保留生育功能治疗后复发的诊治[J]. 山东大学学报 (医学版), 2018, 56(5): 23-29.
[12] 杨旎,曹冬焱,杨佳欣,游燕,沈铿. 卵巢支持间质细胞肿瘤保留生育功能治疗的预后及相关因素[J]. 山东大学学报 (医学版), 2018, 56(5): 30-34.
[13] 中国医师协会检验医师分会妇科肿瘤检验医学专家委员会. 妇科肿瘤标志物应用专家共识[J]. 山东大学学报 (医学版), 2018, 56(10): 3-8.
[14] 中国医师协会检验医师分会肺癌检验医学专家委员会. 肺癌实验室诊断专家共识[J]. 山东大学学报 (医学版), 2018, 56(10): 9-17.
[15] 高春芳,黄晨军. 肝内胆管细胞癌肿瘤标志物研究与临床应用进展[J]. 山东大学学报 (医学版), 2018, 56(10): 24-30.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!