关键词: 25(OH)D, 胰岛素抵抗, 空腹血糖, 糖尿病

Abstract:

Objective  To analyze the relationships among serum 25-hydroxy Vitamin D［25(OH)D］ level, fasting blood glucose(FBG) and insulin sensitivity in the adults of Chinese Han population  from Jinan. Methods  A total of 1244 subjects who lived in Jinan more than five years and aged between 20 to 82 years were included with random sampling method in this cross-sectional study. All individuals were divided into four groups based on the serum level of 25(OH)D:group A (≤32.1nmol/L), group B (32.2-37.7nmol/L), group C (37.8-47.4nmol/L) and group D(≥47.5nmol/L). Analysis of covariance was performed to compare serum FBG levels in the four groups. Simple and partial correlations and bivariate logistic regression analysis were used to explore the associations among FBG, insulin sensitivity and serum level of 25(OH)D. Results  The estimated prevalence of impaired fasting glucose was nearly 9.24%. After adjustments for age and gender, FBG showed a decrease with the increase of serum 25(OH)D level. After adjustments for the confounding factors such as age, gender, drinking status, body mass index, systolic blood pressure, high-density lipoprotein cholesterol  and uric acid, serum 25(OH)D level showed significant inverse correlation to FBG(r=-0.086， P=0.002) and significant positive correlation to log HOMA-β (r=0.079， P=0.005), whereas no significant correlation was found between log HOMA-IR and 25(OH)D. Bivariate Logistic regression analysis showed that serum 25(OH)D level was associated with impaired fasting glucose and Vitamine D may be a protective factor for FBG(OR=0.974, 95%CI: 0.955-0.992, P=0.006). Conclusion  Serum 25(OH)D level is closely related to FBG and the low 25(OH)D level may be a risk factor for impaired fasting glucose.

Key words: 25-hydroxy Vitamin D, Insulin resistance, Fasting blood glucose, Diabetes mellitus