子痫前期胎盘中HIF1α和Endoglin的表达及其与血清中sEng的相关性研究

山东大学学报(医学版)

子痫前期胎盘中HIF1α和Endoglin的表达及其
与血清中sEng的相关性研究

尚慧¹，陈丽君¹，邢静²

（1. 山东大学齐鲁医院妇产科，济南 250012； 2. 武警医学院附属医院妇产科，天津 300162）

收稿日期:1900-01-01 修回日期:1900-01-01 发布日期:2009-04-16
通讯作者: 陈丽君

Relationship of hypoxiainducible factor1α and Endoglin in the placenta with the serum soluble endoglin in preeclampsia

SHANG Hui¹,　CHEN Lijun¹,　XING Jing²

（1. Department of Obstetrics, Qilu Hospital of Shandong University, Jinan 250012, China;
2. Department of Obstetrics, Chinese People′s Armed Police Forces Hospital,Tianjin 300162, China）

Received:1900-01-01 Revised:1900-01-01 Published:2009-04-16
Contact: CHEN Lijun

摘要/Abstract

摘要： 目的探讨子痫前期患者胎盘组织中缺氧诱导因子1α（HIF1α）、Endoglin和血清中可溶性Endoglin(sEng)的表达。方法用免疫组织化学SP法检测20例正常妊娠妇女（对照组）和40例子痫前期患者（子痫前期组，其中轻度子痫前期组10例，重度子痫前期组30例）胎盘组织中HIF1α和Endoglin的表达，双抗体夹心酶联免疫吸附(ELISA)法检测血清sEng的水平，并进行统计分析。结果①HIF1α、Endoglin及sEng水平在子痫前期组中的表达较对照组明显升高（P<0.01），三者在重度子痫前期组中的表达较轻度子痫前期组明显升高（P<0.01）；②子痫前期组HIF1α的表达与Endoglin及血清中sEng的表达均呈正相关关系（r分别为0.686、0.866）。结论子痫前期患者胎盘HIF1α的表达增高可引起胎盘中Endoglin和血清中sEng增多，从而共同参与子痫前期的病理过程。

关键词: 子痫, 胎盘, 缺氧诱导因子1α, Endoglin, 可溶性Endoglin

Abstract: To investigate expressions of hypoxiainducible factor1α and Endoglin in the placenta and the serum soluble endoglin in preeclampsia. MethodsExpressions of HIF1α and Endoglin in the placenta collected from 40 pregnant women with preeclampsia（including mild and severe preeclampsia）and 20 normal pregnant women were determined by immunohistochemistry. The level of soluble endoglin in the serum was detected by enzyme linked immunosorbent assay. Results①Expressions of HIF1α and Endoglin protein in preeclampsia placenta were significantly higher than those in normal placenta (P<0.01), and were higher in the severe group than those in the mild group (P<0.01). ② The level of sEng in the serum of the preeclampsia group was significantly higher than that of the controls (P＜0.01) and was higher in the severe group than in the mild group(P<0.01). ③In the preeclampsia group, HIF1α expression in the placenta was positively correlated with expression of Endoglin in the placenta(r=0.686) and in the serum level（r=0.866). ConclusionAbnormal excess expression of HIF1α in the placenta may induce high expression of Endoglin in the placenta and sEng in the serum, which may be involved in the pathophysiological processes of preeclampsia.

Key words: Preeclampsia, Placenta, HIF1α, Endoglin, Soluble endoglin

中图分类号:

R714.24

尚慧1 ，陈丽君1 ，邢静2
. 子痫前期胎盘中HIF1α和Endoglin的表达及其
与血清中sEng的相关性研究[J]. 山东大学学报(医学版), 2009, 47(04): 98-100.

SHANG Hui¹,　CHEN Lijun¹,　XING Jing².

Relationship of hypoxiainducible factor1α and Endoglin in the placenta with the serum soluble endoglin in preeclampsia

[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2009, 47(04): 98-100.

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