山东大学学报 (医学版) ›› 2026, Vol. 64 ›› Issue (9): 100-110.doi: 10.6040/j.issn.1671-7554.0.2026.0084
• 综述 • 上一篇
尤欣语1, 王文华1, 王森1, 刘少壮2, 黄鑫2, 刘腾2, 王保珍1
YOU Xinyu1, WANG Wenhua1, WANG Sen1, LIU Shaozhuang2, HUANG Xin2, LIU Teng2, WANG Baozhen1
摘要： 代谢相关脂肪性肝病(metabolic dysfunction-associated fatty liver disease, MAFLD)是全球突出的公共卫生问题之一,其发生发展与氧化应激密切相关。膳食是外源性抗氧化剂的主要来源,但既往研究多聚焦单一营养素或特定膳食模式,难以量化个体整体膳食抗氧化水平,导致膳食抗氧化能力与MAFLD关联的结论存在分歧,缺乏可指导临床实践的整合性证据。本文比较了膳食总抗氧化能力(dietary total antioxidant capacity, DTAC)和复合膳食抗氧化指数(composite dietary antioxidant index, CDAI)这两个核心评价指标的差异,并从方法学异质性、病理阶段特异性及人群代谢特征等角度,解析现有结论不一致的原因;围绕MAFLD的氧化应激机制、膳食抗氧化评价指标及其与MAFLD的关联证据三个方面,总结当前研究进展,为MAFLD的膳食干预和临床防治提供理论依据。
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| [1] Eslam M, Sanyal A J, George J, et al. MAFLD: a consensus-driven proposed nomenclature for metabolic associated fatty liver disease[J]. Gastroenterology, 2020, 158(7): 1999-2014. [2] Devarbhavi H, Asrani S K, Arab J P, et al. Global burden of liver disease: 2023 update[J]. J Hepatol, 2023, 79(2): 516-537. [3] Riazi K, Azhari H, Charette J H, et al. The prevalence and incidence of NAFLD worldwide: a systematic review and meta-analysis[J]. Lancet Gastroenterol Hepatol, 2022, 7(9): 851-861. [4] Zhou J H, Zhou F, Wang W X, et al. Epidemiological features of NAFLD from 1999 to 2018 in China[J]. Hepatology, 2020, 71(5): 1851-1864. [5] Younossi Z M, Kalligeros M, Henry L. Epidemiology of metabolic dysfunction-associated steatotic liver disease[J]. Clin Mol Hepatol, 2025, 31: S32-S50. DOI:10.3350/cmh.2024.0431 [6] Sun D Q, Jin Y, Wang T Y, et al. MAFLD and risk of CKD[J]. Metabolism, 2021, 115: 154433. DOI:10.1016/j.metabol.2020.154433 [7] Liu Z Q, Lin C Q, Suo C, et al. Metabolic dysfunction-associated fatty liver disease and the risk of 24 specific cancers[J]. Metabolism, 2022, 127: 154955. DOI:10.1016/j.metabol.2021.154955 [8] Liang Y B, Chen H L, Liu Y X, et al. Association of MAFLD with diabetes, chronic kidney disease, and cardiovascular disease: a 4.6-year cohort study in China[J]. J Clin Endocrinol Metab, 2022, 107(1): 88-97. [9] Zhou X D, Targher G, Byrne C D, et al. An international multidisciplinary consensus statement on MAFLD and the risk of CVD[J]. Hepatol Int, 2023, 17(4): 773-791. [10] Portincasa P, Khalil M, Mahdi L, et al. Metabolic dysfunction-associated steatotic liver disease: from pathogenesis to current therapeutic options[J]. Int J Mol Sci, 2024, 25(11): 5640. DOI:10.3390/ijms25115640 [11] Tauil R B, Golono P T, de Lima E P, et al. Metabolic-associated fatty liver disease: the influence of oxidative stress, inflammation, mitochondrial dysfunctions, and the role of polyphenols[J]. Pharmaceuticals(Basel), 2024, 17(10): 1354. DOI:10.3390/ph17101354 [12] Arroyave-Ospina J C, Wu Z M, Geng Y N, et al. Role of oxidative stress in the pathogenesis of non-alcoholic fatty liver disease: implications for prevention and therapy[J]. Antioxidants, 2021, 10(2): 174. DOI:10.3390/antiox10020174 [13] Loomba R, Friedman S L, Shulman G I. Mechanisms and disease consequences of nonalcoholic fatty liver disease[J]. Cell, 2021, 184(10): 2537-2564. [14] Hu Z N, Yue H X, Jiang N, et al. Diet, oxidative stress and MAFLD: a mini review[J]. Front Nutr, 2025, 12: 1539578. DOI:10.3389/fnut.2025.1539578 [15] Clare K, Dillon J F, Brennan P N. Reactive oxygen species and oxidative stress in the pathogenesis of MAFLD[J]. J Clin Transl Hepatol, 2022, 10(5): 939-946. [16] He Y H, Wang H, Lin S L, et al. Advanced effect of curcumin and resveratrol on mitigating hepatic steatosis in metabolic associated fatty liver disease via the PI3K/AKT/mTOR and HIF-1/VEGF cascade[J]. Biomed Pharmacother, 2023, 165: 115279. DOI:10.1016/j.biopha.2023.115279 [17] Luo X Q, Zhang W Y, He Z Y, et al. Dietary vitamin C intake is associated with improved liver function and glucose metabolism in Chinese adults[J]. Front Nutr, 2021, 8: 779912. DOI:10.3389/fnut.2021.779912 [18] Amanullah I, Khan Y H, Anwar I, et al. Effect of vitamin E in non-alcoholic fatty liver disease: a systematic review and meta-analysis of randomised controlled trials[J]. Postgrad Med J, 2019, 95(1129): 601-611. [19] Lee S W, Lee Y J, Baek S M, et al. Mega-dose vitamin C ameliorates nonalcoholic fatty liver disease in a mouse fast-food diet model[J]. Nutrients, 2022, 14(11): 2195. DOI:10.3390/nu14112195 [20] Vahid F, Rahmani D, Hekmatdoost A. The association between dietary antioxidant index(DAI)and nonalcoholic fatty liver disease(NAFLD)onset; new findings from an incident case-control study[J]. Clin Nutr ESPEN, 2021, 41: 360-364. DOI:10.1016/j.clnesp.2020.10.020 [21] Sohouli M H, Fatahi S, Sayyari A, et al. Associations between dietary total antioxidant capacity and odds of non-alcoholic fatty liver disease(NAFLD)in adults: a case-control study[J]. J Nutr Sci, 2020, 9: e48. DOI:10.1017/jns.2020.39 [22] Salehi-Sahlabadi A, Mokari A, Elhamkia M, et al. Die-tary total antioxidant capacity and risk of non-alcoholic fatty liver disease: a case-control study[J]. J Res Health Sci, 2020, 20(3): e00486. DOI:10.34172/jrhs.2020.18 [23] Chen Z, Tian R F, She Z G, et al. Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver di-sease[J]. Free Radic Biol Med, 2020, 152: 116-141. DOI:10.1016/j.freeradbiomed.2020.02.025 [24] Allameh A, Niayesh-Mehr R, Aliarab A, et al. Oxidative stress in liver pathophysiology and disease[J]. Antioxidants(Basel), 2023, 12(9): 1653. DOI:10.3390/antiox12091653 [25] Ferramosca A, di Giacomo M, Zara V. Antioxidant die-tary approach in treatment of fatty liver: new insights and updates[J]. World J Gastroenterol, 2017, 23(23): 4146-4157. [26] Guo X Y, Yin X Z, Liu Z J, et al. Non-alcoholic fatty liver disease(NAFLD)pathogenesis and natural pro-ducts for prevention and treatment[J]. Int J Mol Sci, 2022, 23(24): 15489. DOI:10.3390/ijms232415489 [27] Pafili K, Roden M. Nonalcoholic fatty liver disease(NAFLD)from pathogenesis to treatment concepts in humans[J]. Mol Metab, 2021, 50: 101122. DOI:10.1016/j.molmet.2020.101122 [28] Franceschetti L, Bonomini F, Rodella L F, et al. Critical role of NF-κB in the pathogenesis of non-alcoholic fatty liver disease: a widespread key regulator[J]. Curr Mol Med, 2021, 21(6): 495-505. [29] Xu J Q, Shen J Y, Yuan R L, et al. Mitochondrial targeting therapeutics: promising role of natural products in non-alcoholic fatty liver disease[J]. Front Pharmacol, 2021, 12: 796207. DOI:10.3389/fphar.2021.796207 [30] Baratta F, Pastori D, Bartimoccia S, et al. Poor adhe-rence to Mediterranean diet and serum lipopolysaccharide are associated with oxidative stress in patients with non-alcoholic fatty liver disease[J]. Nutrients, 2020, 12(6): 1732. DOI:10.3390/nu12061732 [31] El-Sehrawy A A M A, Mohammed A N, Gupta J, et al. Combating oxidative stress in non-alcoholic fatty liver disease: from mechanisms to therapeutic strategies[J]. Pathol Res Pract, 2025, 272: 156053. DOI:10.1016/j.prp.2025.156053 [32] Li R, Chen Z X. Validation and comparison of two die-tary indexes for predicting nonalcoholic fatty liver disease in US adults[J]. J Nutr, 2023, 152(12): 2865-2876. [33] Poulos J E, Kalogerinis P T, Milanov V, et al. The effects of vitamin E, silymarin and carnitine on the metabolic abnormalities associated with nonalcoholic liver di-sease[J]. J Diet Suppl, 2022, 19(3): 287-302. [34] Aranda N, Valls R M, Romeu M, et al. Consumption of seafood and its estimated heavy metals are associated with lipid profile and oxidative lipid damage on healthy adults from a Spanish Mediterranean area: a cross-sectional study[J]. Environ Res, 2017, 156: 644-651. DOI:10.1016/j.envres.2017.04.037 [35] Whalen K A, McCullough M L, Flanders W D, et al. Paleolithic and Mediterranean diet pattern scores are inversely associated with biomarkers of inflammation and oxidative balance in adults[J]. J Nutr, 2016, 146(6): 1217-1226. [36] Luisi M L E, Lucarini L, Biffi B, et al. Effect of Mediterranean diet enriched in high quality extra virgin olive oil on oxidative stress, inflammation and gut microbiota in obese and normal weight adult subjects[J]. Front Pharmacol, 2019, 10: 1366. DOI:10.3389/fphar.2019.01366 [37] Barrea L, Verde L, Savastano S, et al. Adherence to Mediterranean diet: any association with NAFLD?[J]. Antioxidants(Basel), 2023, 12(7): 1318. DOI:10.3390/antiox12071318 [38] Alkan ?瘙塁 B, Artaç M, Aksoy F, et al. The evaluation of dietary antioxidant capacity, dietary inflammatory index and serum biomarkers in breast cancer: a prospective study[J]. Nutr Cancer, 2023, 75(8): 1625-1637. [39] Liu Y B, Chen M K. Dietary and lifestyle oxidative ba-lance scores are independently and jointly associated with nonalcoholic fatty liver disease: a 20 years nationally representative cross-sectional study[J]. Front Nutr, 2023, 10: 1276940. DOI:10.3389/fnut.2023.1276940 [40] Wu S J, Liao X Y, Zhu Z J, et al. Antioxidant and anti-inflammation effects of dietary phytochemicals: the Nrf2/NF-κB signalling pathway and upstream factors of Nrf2[J]. Phytochemistry, 2022, 204: 113429. DOI:10.1016/j.phytochem.2022.113429 [41] Konstantinidou V, Covas M I, Sola R, et al. Up-to date knowledge on the in vivo transcriptomic effect of the Mediterranean diet in humans[J]. Mol Nutr Food Res, 2013, 57(5): 772-783. [42] Ravaut G, Légiot A, Bergeron K F, et al. Monounsa-turated fatty acids in obesity-related inflammation[J]. Int J Mol Sci, 2021, 22(1): 330. DOI:10.3390/ijms22010330 [43] Rives C, Fougerat A, Ellero-Simatos S, et al. Oxidative stress in NAFLD: role of nutrients and food contaminants[J]. Biomolecules, 2020, 10(12): 1702. DOI:10.3390/biom10121702 [44] Zhou B, Luo Y C, Bi H Q, et al. Amelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11[J]. Cell Metab, 2024, 36(10): 2228-2244. [45] Bo T, Gao L, Yao Z Y, et al. Hepatic selective insulin resistance at the intersection of insulin signaling and me-tabolic dysfunction-associated steatotic liver disease[J]. Cell Metab, 2024, 36(5): 947-968. [46] Chen L L, Fan Z Q, Sun X D, et al. Diet-derived antioxidants and nonalcoholic fatty liver disease: a Mendelian randomization study[J]. Hepatol Int, 2023, 17(2): 326-338. [47] Anderson E J, Thayne K A, Harris M, et al. Do fish oil omega-3 fatty acids enhance antioxidant capacity and mitochondrial fatty acid oxidation in human atrial myocar-dium via PPARγ activation?[J]. Antioxid Redox Signal, 2014, 21(8): 1156-1163. [48] Lagouge M, Argmann C, Gerhart-Hines Z, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α[J]. Cell, 2006, 127(6): 1109-1122. [49] Wang J, Zou Q H, Suo Y, et al. Lycopene ameliorates systemic inflammation-induced synaptic dysfunction via improving insulin resistance and mitochondrial dysfunction in the liver-brain axis[J]. Food Funct, 2019, 10(4): 2125-2137. [50] Quesada-Vázquez S, Aragonès G, Del Bas J M, et al. Diet, gut microbiota and non-alcoholic fatty liver disease: three parts of the same axis[J]. Cells, 2020, 9(1): 176. DOI:10.3390/cells9010176 [51] Calabrese F M, Disciglio V, Franco I, et al. A low glycemic index Mediterranean diet combined with aerobic physical activity rearranges the gut microbiota signature in NAFLD patients[J]. Nutrients, 2022, 14(9): 1773. DOI:10.3390/nu14091773 [52] Shin J H, Lee Y, Song E J, et al. Faecalibacteriumprausnitzii prevents hepatic damage in a mouse model of NASH induced by a high-fructose high-fat diet[J]. Front Microbiol, 2023, 14: 1123547. DOI:10.3389/fmicb.2023.1123547 [53] Eaton S M, Chai W W, Moss O, et al. Relationship between diet quality, intestinal permeability, and gut microbiota features in individuals with obesity[J]. Nutrients, 2026, 18(5): 775. DOI:10.3390/nu18050775 [54] Cuciniello R, Di Meo F, Filosa S, et al. The antioxidant effect of dietary bioactives arises from the interplay between the physiology of the host and the gut microbiota: involvement of short-chain fatty acids[J]. Antioxidants, 2023, 12(5): 1073. DOI:10.3390/antiox12051073 [55] Jansen E, Ruskovska T. Serum biomarkers of(anti)oxidant status for epidemiological studies[J]. Int J Mol Sci, 2015, 16(11): 27378-27390. [56] Jungert A, Frank J. Intra-individual variation and reliability of biomarkers of the antioxidant defense system by considering dietary and lifestyle factors in premenopausal women[J]. Antioxidants(Basel), 2021, 10(3): 448. DOI:10.3390/antiox10030448 [57] Wang Y, Yang M, Lee S G, et al. Dietary total antioxidant capacity is associated with diet and plasma antioxidant status in healthy young adults[J]. J Acad Nutr Diet, 2012, 112(10): 1626-1635. [58] Çolak B B Ö, Kürklü N S, Adıgüzel K T, et al. Dietary and serum antioxidant capacity is inversely associated with patients in osteoarthritis: a case-control study[J]. J Health PopulNutr, 2024, 43(1): 101. DOI:10.1186/s41043-024-00566-8 [59] Hernández-Ruiz A, García-Villanova B, Guerra-Hernández E, et al. Comparison of the dietary antioxidant profiles of 21 a priori defined Mediterranean diet indexes[J]. J Acad Nutr Diet, 2018, 118(12): 2254-2268. [60] Saura-Calixto F, Goñi I. Antioxidant capacity of the Spanish Mediterranean diet[J]. Food Chem, 2006, 94(3): 442-447. [61] Aleksandrova K, Koelman L, Rodrigues C E. Dietary patterns and biomarkers of oxidative stress and inflammation: a systematic review of observational and intervention studies[J]. Redox Biol, 2021, 42: 101869. DOI:10.1016/j.redox.2021.101869 [62] Floegel A, Kim D O, Chung S J, et al. Development and validation of an algorithm to establish a total antioxidant capacity database of the US diet[J]. Int J Food Sci Nutr, 2010, 61(6): 600-623. [63] Sheng L T, Jiang Y W, Pan A, et al. Dietary total antioxidant capacity and mortality outcomes: the Singapore Chinese Health Study[J]. Eur J Nutr, 2022, 61(5): 2375-2382. [64] Kong J S, Lee J, Kim Y, et al. Associations of cumulative average dietary total antioxidant capacity and intake of antioxidants with metabolic syndrome risk in Korean adults aged 40 years and older: a prospective cohort study(KoGES_CAVAS)[J]. Epidemiol Health, 2023, 45: e2023067. DOI:10.4178/epih.e2023067 [65] Pashayee-Khamene F, Hajimohammadebrahim-Ketabforoush M, Heidari Z, et al. Dietary total antioxidant capacity in relation to disease severity and risk of mortality in cirrhosis; results from a cohort study[J]. Heliyon, 2024, 10(18): e37733. DOI:10.1016/j.heliyon.2024.e37733 [66] Heshmati S, Moludi J, Nachvak S M, et al. The association of dietary total antioxidant capacity and gestational diabetes: a prospective cohort study from the Mothers and their childrens health(MATCH)[J]. Nutr Diabetes, 2024, 14: 78. DOI:10.1038/s41387-024-00333-y [67] Li Y, Ling G C, Ni R B, et al. Association of dietary total antioxidant capacity with all-cause and cardiovascular mortality in patients with chronic kidney disease: based on two retrospective cohort studies of NHANES[J]. Ren Fail, 2023, 45(1): 2205950. DOI:10.1080/0886022X.2023.2205950 [68] Wang Y, Yang M, Lee S G, et al. Plasma total antioxidant capacity is associated with dietary intake and plasma level of antioxidants in postmenopausal women[J]. J Nutr Bio chem, 2012, 23(12): 1725-1731. [69] Nouri M, Soltani M, Rajabzadeh-Dehkordi M, et al. Dietary antioxidant capacity indices are negatively correlated to LDL-oxidation in adults[J]. Int J Clin Pract, 2023, 2023: 5446163. DOI:10.1155/2023/5446163 [70] do Nascimento Peixoto T, de Assis Lima L C B, Lima J G, et al. Dietary total antioxidant capacity and polyphenol intake benefit the inflammatory profile and HDL-C concentrations in individuals with metabolic syndrome[J]. Nutr Res, 2025, 139: 100-112. DOI:10.1016/j.nutres.2025.05.002 [71] Wright M E, Mayne S T, Stolzenberg-Solomon R Z, et al. Development of a comprehensive dietary antioxidant index and application to lung cancer risk in a cohort of male smokers[J]. Am J Epidemiol, 2004, 160(1): 68-76. [72] Ma R C, Zhou X Y, Zhang G L, et al. Association between composite dietary antioxidant index and coronary heart disease among US adults: a cross-sectional analysis[J]. BMC Public Health, 2023, 23(1): 2426. DOI:10.1186/s12889-023-17373-1 [73] Wang M H, Shi H. Composite dietary antioxidant index is nonlinearly associated with low muscle mass in the general US population: findings from NHANES 2001-2018[J]. Nutr J, 2025, 24(1): 92. DOI:10.1186/s12937-025-01166-w [74] Vahid F, Rahmani D, Davoodi S H. The correlation between serum inflammatory, antioxidant, glucose handling biomarkers, and Dietary Antioxidant Index(DAI)and the role of DAI in obesity/overweight causation: population-based case-control study[J]. Int J Obes, 2021, 45(12): 2591-2599. [75] Jiménez-Ortega R F, Meneses-León J, Hernández S, et al. High dietary antioxidant index associated with reduced insulin resistance in female Mexican children and adolescents[J]. Nutr Res, 2024, 132: 53-66. DOI:10.1016/j.nutres.2024.09.016 [76] Zhou A Y, Li P, Feng L, et al. Systemic immune-inflammation index-mediated association of composite dietary antioxidant index with obesity in children and adolescents: based on NHANES 2011-2018[J]. Lipids Health Dis, 2025, 24(1): 384. DOI:10.1186/s12944-025-02798-x [77] Zheng Y Y, Liu W L, Zhu X Y, et al. Associations of dietary inflammation index and composite dietary antioxidant index with preserved ratio impaired spirometry in US adults and the mediating roles of triglyceride-glucose index: NHANES 2007-2012[J]. Redox Biol, 2024, 76: 103334. DOI:10.1016/j.redox.2024.103334 [78] Lv J M, Lin P H, Yao Q Z, et al. Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems[J]. J Cell Mol Med, 2010, 14(4): 840-860. [79] Gulcin(·overI). Antioxidants: a comprehensive review[J]. Arch Toxicol, 2025, 99(5): 1893-1997. [80] Terao J. Revisiting carotenoids as dietary antioxidants for human health and disease prevention[J]. Food Funct, 2023, 14(17): 7799-7824. [81] Miazek K, Beton K, Sliwińska A, et al. The effect of β-carotene, tocopherols and ascorbic acid as anti-oxidant molecules on human and animal in vitro/in vivo studies: a review of research design and analytical techniques used[J]. Biomolecules, 2022, 12(8): 1087. DOI:10.3390/biom12081087 [82] Wu M Y, Si J Y, Liu Y H, et al. Association between composite dietary antioxidant index and hypertension: insights from NHANES[J]. Clin Exp Hypertens, 2023, 45(1): 2233712. DOI:10.1080/10641963.2023.2233712 [83] Teng T Q, Liu J, Hu F F, et al. Association of compo-site dietary antioxidant index with prevalence of stroke: insights from NHANES 1999-2018[J]. Front Immunol, 2024, 15: 1306059. DOI:10.3389/fimmu.2024.1306059 [84] Ding W, Liu H M, Qin Z Q, et al. Dietary antioxidant anthocyanins mitigate type II diabetes through improving the disorder of glycometabolism and insulin resistance[J]. J Agric Food Chem, 2021, 69(45): 13350-13363. [85] Dong J X, Jiang L L, Liu Y P, et al. Association between composite dietary antioxidant index and metabolic dysfunction-associated fatty liver disease: a cross-sectional study from NHANES[J]. BMC Gastroenterol, 2024, 24(1): 465. DOI:10.1186/s12876-024-03556-6 [86] Fu Y D, Jiang C, Li Z L, et al. Association between the composite dietary antioxidant index and non-alcoholic fatty liver disease: evidence from National Health and Nutrition Examination Survey 2005-2016[J]. Front Nutr, 2025, 12: 1473487. DOI:10.3389/fnut.2025.1473487 [87] Ding Y C, Fan M M, Jiang C, et al. Association of composite dietary antioxidant index with the risk of nonalcoholic fatty liver disease and all-cause and cause-specific mortality: evidence from NHANES 2001-2018[J]. Int J Endocrinol, 2025, 2025: 3255533. DOI:10.1155/ije/3255533 [88] Gao L X, Fang H Y, Zhao Z B, et al. Synergistic impact of Composite Dietary Antioxidant Index and physical activity on fatty liver disease[J]. Front Nutr, 2024, 11: 1486700. DOI:10.3389/fnut.2024.1486700 [89] Georgoulis M, Fragopoulou E, Kontogianni M D, et al. Blood redox status is associated with the likelihood of nonalcoholic fatty liver disease irrespectively of diets total antioxidant capacity[J]. Nutr Res, 2015, 35(1): 41-48. [90] Hua S Y, Zhong W, Sha Y P, et al. Negative association of composite dietary antioxidant index with risk of hepatic fibrosis in individuals underwent cholecystectomy: a cross-sectional study[J]. Sci Rep, 2025, 15(1): 9040. DOI:10.1038/s41598-025-93782-z [91] French C D, Arsenault J E, Arnold C D, et al. Within-person variation in nutrient intakes across populations and settings: implications for the use of external estimates in modeling usual nutrient intake distributions[J]. Adv Nutr, 2021, 12(2): 429-451. [92] de Oliveira D G, de Faria Ghetti F, Moreira A P B, et al. Association between dietary total antioxidant capacity and hepatocellular ballooning in nonalcoholic steatohepatitis: a cross-sectional study[J]. Eur J Nutr, 2019, 58(6): 2263-2270. [93] Kamrani F, Nikparast A, Etesami E, et al. Dietary antioxidant capacity, flavonoid subclasses, and metabolic dysfunction-associated fatty liver disease in overweight and obese youth[J]. J Health Popul Nutr, 2025, 44(1): 420. DOI:10.1186/s41043-025-01155-z [94] Salavatizadeh M, Soltanieh S, Poustchi H, et al. Dietary total antioxidant capacity is inversely associated with the odds of non-alcoholic fatty liver disease in people with type-2 diabetes[J]. Front Nutr, 2022, 9: 1037851. DOI:10.3389/fnut.2022.1037851 [95] Quetglas-Llabrés M M, Monserrat-Mesquida M, Bouzas C, et al. Impact of adherence to the Mediterranean diet on antioxidant status and metabolic parameters in NAFLD patients: a 24-month lifestyle intervention study[J]. Antioxidants(Basel), 2024, 13(4): 480. DOI:10.3390/antiox13040480 [96] Quetglas-Llabrés M M, Monserrat-Mesquida M, Bouzas C, et al. Effects of a two-year lifestyle intervention on intrahepatic fat reduction and renal health: mitigation of inflammation and oxidative stress, a randomized trial[J]. Antioxidants(Basel), 2024, 13(7): 754. DOI:10.3390/antiox13070754 [97] Zhang K N, Xu Y, Zhang N, et al. Association of the composite dietary antioxidant index and consumption time with NAFLD: the U.S. national health and nutrition examination survey, 2017-2020[J]. Nutrients, 2024, 16(20): 3556. DOI:10.3390/nu16203556 [98] Zhen Y K, Xi Z N, Hu L Y, et al. Impacts of circadian gene Period2 knockout on intestinal metabolism and hepatic antioxidant and inflammation state in mice[J]. Oxid Med Cell Longev, 2022, 2022: 7896371. DOI:10.1155/2022/7896371 [99] Sennels H P, Jørgensen H L, Fahrenkrug J. Diurnal changes of biochemical metabolic markers in healthy young males-the Bispebjerg study of diurnal variations[J]. Scand J Clin Lab Invest, 2015, 75(8): 686-692. |
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