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Protective effect of Ligustrazine bisphenylmethyl piperazine derivatives on ECV-304 cells injured by hydrogen peroxide

CHENG Xian-chao1,LIU Xin-yong1,XU Wen-fang1,GUO Xiu-li2,OU Yang2   

  1. 1. Institute of Medicinal Chemistry; 2. Institute of Pharmacology, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
  • Received:2007-01-22 Revised:1900-01-01 Online:2007-09-24 Published:2007-09-24
  • Contact: LIU Xin-yong

Abstract: Objective: To evaluate the protective effect of Ligustrazine bisphenylmethyl piperazine derivatives on ECV-304 cells injured by hydrogen peroxide. Methods: ECV-304 cells were injured by hydrogen peroxide and assessed by methyl thiazolyl tetrazolium (MTT) assay. Results: Ligustrazine bisphenylmethyl piperazine derivatives showed protective effects on ECV-304 cells injured by hydrogen peroxide, which were more effective than Ligustrazine. Conclusion: Ligustrazine bisphenylmethyl piperazine derivatives can protect ECV-304 cells against hydrogen peroxide injury.

Key words: Ligustrazine, Derivatives, ECV-304 cells, Hydrogen peroxide, Injuries

CLC Number: 

  • R965
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