JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

• Articles • Previous Articles     Next Articles

mRNA expression of lunx in regional lymph nodes of non-small cell lung cancer and its correlation with prognosis

NIU Rui1，LIU Bo2，SHAO Ming-ju1，WANG Wei1   

  1. 1． Department of Respiratory, Second Hospital of Shandong University, Jinan 250033, Shandong, China;2． Department of Respiratory, Weihai Municipal Hospital, Weihai 264200, Shandong, China
  • Received:2007-07-29 Revised:1900-01-01 Online:2007-09-24 Published:2007-09-24
  • Contact: WANG Wei

PDF (PC)

675

Abstract: Objective： To explore the mRNA expression of lunx in regional lymph nodes of non-small cell lung cancer (NSCLC) and its correlation with prognosis. Methods SYBR greenⅠreal-time RT-PCR was used to determine the lunx mRNA level in 153 regional lymph nodes obtained from 75 patients with NSCLC. All patients had been followed up for 3 years. Six factors that may influence the survival rate were analyzed by a Cox regression model. Results： Expressions of lunx in regional lymph nodes had a statistical correlation with age, nutritional index, relapse within 3 years and metastasis(P＜0.01, P＜0.01, and P＜0.05) but had no correlation with gender, tumor types and pathological grades（P＞0.05). There were statistical significances between the survival of NSCLC patients and post-operative adjuvant therapy and expression of lunx (P＜0.05 and P＜0.01). Conclusions： The expression of Lunx in regional lymph nodes closely correlates with the survival of NSCLC patients and it may be a target gene for detection of micrometastasis from NSCLC and a marker for detection in 3 years prognosis. Quantitative real-time RT-PCR is helpful in early diagnosis of micrometastasis of the lymph node in patients with NSCLC.

Key words: Lung neoplasms, Micrometastasis, Lunx, RT-PCR

CLC Number: 

  • R734.2
[1] GU Xu, WANG Xiaqing, REN Wanhua, QIN Chengyong, HAN Guoqing. Expression and clinical significance of NPRL2 and Survivin in hepatocellular carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(6): 68-72.
[2] LIU Yimin, DU Lutao, WANG Lili, JIANG Xiumei, LI Juan, QU Ailin, WANG Haiyan, ZHENG Guixi, ZHANG Xin,YANG Yongmei, WANG Chuanxin. Identification and validation of suitable reference genes for the investigation of serum microRNA in bladder cancer patients [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(5): 86-91.
[3] ZU Shan-shan1, MA Xiao-li1,2, JIA Yan-fei1,2, ZHAO Yun3, JIA Ying1, XIAO Dong-jie1,2, WANG Yun-shan1,2. Effects of down-regulated α5-nicotinic acetylcholine receptor expression on HIF-1α expression in lung cancer cells [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(9): 8-12.
[4] ZHANG Lin1, ZHANG Zhen-jiang2, MENG Long1, MA Wei1, DU Jia-jun1. Surgical treatment for malignant focal ground glass opacity lung nodule [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(9): 84-87.
[5] CAO Hong-li1, LIU Shu-ying2. Relationship of plasma concentration of brain natriuretic peptide and lung cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(8): 62-64.
[6] LIU Bing1， YU Zhuang1， HOU Xian-peng1， YAO Ru-yong2. Different expressions of EGFR and HER-3 genes in human lung adenocarcinoma cells and pemetrexed-resistant cells [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(5): 20-23.
[7] FAN Ming-de1, ZHANG Yuan2, MIAO Bao-wang1, ZHENG Kun-peng1, LI Ke1, WANG Cheng-wei1. Expression of Nod-like receptor pyrin domain-containing protein 3 (NLRP3) in glioma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(4): 51-54.
[8] WANG Xue-qin1, YUE Zhong-yong2, LI Ke-zhong1, MA Jin-feng1. Effects of cyclic mechanical stretch on the expression of TLR4 in alveolar macrophages of rats [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(06): 40-43.
[9] TIAN Tian-tian1, LI Ji-sheng1, WANG Ya-wei1, MA Dao-xin2, WANG Xiu-wen1. Genistein exerts antitumor effects in small cell lung cancer H446 cells via suppressing the activity of FoxM1 pathway [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(06): 44-48.
[10] LIU Qing-liang1, MU Xiao-yan1, WANG-Jing2, CHI Xiang-yu2, ZHANG Min3, MA Wei-xia3. Inhibitory effects of RNA interference and Erlotinib by blocking epidermal
growth factor receptor pathway on the proliferation of A549 cells [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(9): 11-.
[11] LIU Hai-rong1， YU Jin-ming2， LI Yan1， LIANG Jing1， LIU Xiao-lin1. Study of the relationship between ER， PR， C-erB-2 and
bone metastasis of  lung adenocacinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(4): 91-.
[12] SUN Xue-fei, PEI Yan-tao,YIN Qiu-wei, YANG Guo-tao, WANG De-jiang. Inhibitory effect of Radix Actinidiae extractive on transplantation
tumor of the lung cancer cell line A549 in nude mice [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(2): 38-42.
[13] ZHANG Zhen-wei1， JIANG Zhong-min2. Expression and clinical significance of Mel-18 mRNA in
esophageal squamous cell carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(2): 78-.
[14] YU Yang1， ZHAO Jian2， ZHONG Kai-ze2， LIU Chun-yan1， LI Yi3， SHI Jing3， CHEN Wei-wen1， JIANG An-li1. Construction of eukaryotic expression vector for human miR-147a and
its effects on the proliferation and invasion of lung cancer cells [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(12): 25-30.
[15] LI Ming-ying1， WANG Guang-li2， CUI Ding-ye2， ZHANG Cheng-qi2. Preliminary study of lung cancer types with gemstone spectral CT imaging [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(12): 73-.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd