Abstract: Objective： To study the preparation of penciclovir liposomes and its quality control. Methods： The optimum preparation technology was established by a uniform design. Negative staining and the laser scattering particle size distribution analyzer were used to study the structure and size of liposomes. A gel column and Kratio spectrophotometry were developed to determine the entrapment efficiency. Results： The average size of liposomes was 426.8nm. The entrapment efficiency was 60.76%. Conclusion： The preparation of penciclovir liposome is practicable and should be investigated further.

Key words: Penciclovir, Lliposome, Quality control