JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

• Articles • Previous Articles     Next Articles

Gene expression regulation between tongue squamous cell carcinoma cell line Tca-8113 and normal tongue mucosa fibroblasts

WANG Zhen-guang, SUN Shan-zhen, SHI Lin, WANG Dong-guan   

  1. Institute of Pathology，School of Stomatology， Shandong University， Jinan 250012， Shandong， China
  • Received:2006-06-18 Revised:1900-01-01 Online:2007-05-24 Published:2007-05-24
  • Contact: WANG Zhen-guang

PDF (PC)

446

Abstract: Objective： To study the gene expression changes of tongue epithelial tumor cell line Tca-8113 and its neighboring fibroblast (normal mucosa fibroblasts NMFs) after co-culture. Methods： Primarily cultured NMFs were co-cultured with Tca-8113. Then, morphological changes were produced. Changes of growth factors (IGFBP1), signal transducers (Notch3), proteasea/proteases inhibitors (ST3，TIMP3，TFPI-2), and extracellular matrix components or associated protein relating to matrix degradation (Tenascin-C) isolated from oral cancer cells， normal mucosa fibroblast and co-culture cells were determined by semiquantiative RT-PCR experiment. Results: After being co-cultured, NMFs grew surrounding Tca-8113. The cellular organs of the two cells grew more than before co-culture. IGFBP1 of Tca-8113 was decreased, however, TFPI-2 of Tca-8113 or Notch3, TIMP-3, ST3, Tenascin-C of NMFs were increased. Conclusion: The potential complex regulation of Tca-8113 and NMFs raises a question concerning the global pro-or anti-tumor consequences of these heterotypic interactions.

Key words: Tongue neoplasms, Fibroblasts, Gene expression regulation

CLC Number: 

  • R739.85
[1] LU Zhenzhen, YAN Lei, ZHANG Hui, ZHANG Xiaohui, ZHAO Xingbo. Effects of TGF β-1 on the activation of endometrial stromal cells in tumor microenvironment [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(9): 37-40.
[2] HAO Lijing, GE Shuqing, WANG Shufen, ZHENG Wenjiao, ZHANG Bin. Effects of sorafenib on the proliferation and apoptosis of cisplatin-resistant tongue cancer cells in vitro [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(1): 17-21.
[3] CHEN Yan, LIU Juan, CHEN Hanxiang, ZHANG Weifang, ZHAO Weiming. Effects of miR-17 on the senescence of human foreskin fibroblasts [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(5): 55-59.
[4] ZHU Zhenkun, ZHOU Qin, SUN Ruinan, XU Xin. Expression of Hsp27 in lipopolysaccharide-induced injury of human gingival fibroblasts [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(3): 36-40.
[5] LIU Zhenzhong, JIANG Duyin, WANG Wei, ZONG Xianlei, ZHANG Jixun, LIU Lei. Proliferative effect of TGF-β1 phage model peptide on fibroblasts [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(3): 50-55.
[6] SHANG Rui1,2, TANG Meng-xiong2,3, LIU Lin1,2, DING Wen-yuan2,3, HAO Pan-pan2,3, CHEN Yu-guo2,3. Role of ALK7 in the transformation of cardiac fibroblasts and the production of collagen type I induced by high glucose [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(8): 1-6.
[7] HAO Wei1, LI Fu-hai2, WANG Yu-lin1. Effects of omega-3 polyunsaturated fatty acids on
keratinocytes and fibroblasts [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(9): 50-54.
[8] WANG Qi-lei1, REN Man-yi2, WANG De-jin1, XU Dong-ling1, DU Yi-meng1, WANG Xu-ping3, SUI Shu-jian1. TWEAK promotes expressions of collagen I and matrix metalloproteinase1
in rat cardiac fibroblasts via P38MAPK pathway [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(11): 43-47.
[9] CHEN Jie1, SONG Yong-hong2, WANG Shu-rong2, HAN Zhen-long3, JIANG Xue-bing1, LI Guo-sheng1, GUO Chun1, ZHANG Li-ning1, SHI Yong-yu1. Identification of human TIPE2 promoter and its regulatory regions [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(7): 39-43.
[10] REN Min1, L Yi-jing1, ZHANG Ji-dong1, Wang Bo1, LIU Ping2. Inhibitory effect of the Qindan capsule on proliferation and migration of adventitial fibroblasts [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(6): 71-.
[11] LIU Jian, WANG Fa-gang, CAO Yong-qian, XU Qian, XU Rong-jian. Effect of sense and antisense VEGF165 cDNA transfection on the  growth of hypertrophic scar-derived fibroblasts in vitro [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(5): 135-139.
[12] LIN Wen-li1, LIU Jie2, LI Zhe3, ZHANG Nan2, LIU Chuan-yong2, LIU Jin-feng1, SUN Yu-ping2. Relationship of expressions of PDGFR-β and podoplanin with cancer-associated fibroblasts and  lymphangiogenesis in NSCLC [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(4): 85-89.
[13] WANG De-jin1， REN Man-yi2， CHEN Hui-na1， WANG Xu-ping3， SUI Shu-jian1. Tumor necrosis factor-like weak inducer of apoptosis promotes expression of matrix metalloproteinase 9 in rat cardiac fibroblasts via the nuclear factor-κB pathway [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(11): 13-17.
[14] SHAN Fei1, JIANG Duyin1, ZONG Xianlei1, FU Xiaobing2, LIU Junli3, ZHAO Jingjie3. Effect of keratinocyte growth factor on epidermis cell proliferation promoted by fibroblasts [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(4): 18-22.
[15] WANG Yibing1, FENG Yongqiang1, ZHANG Rui2, ZHANG Cheng3， LENG Tingting1,　WU Nan1. Effect of fetal rat fibroblasts on wound healing of deep second degree scalds treated with dermabrasion [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(2): 72-.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd