JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

• Articles • Previous Articles     Next Articles

Changes of transforming growth factor-β of human detrusor after bladder outlet obstruction induced by benign prostatic hyperplasia

HAN Zeng-chi1，XU Zhong-hua1，LIU Ben2，YAN Lei1，ZHOU Zun-lin1，CHEN Xiu-de1，LIU Hai-nan1，LIU Zhao-xu1，FAN Yi-dong1，ZHENG Bao-zhong1   

  1. 1. Department of Urology, Qilu Hospital of Shandong University, Jinan 250012;2. Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou 310003
  • Received:2006-05-15 Revised:1900-01-01 Online:2007-01-24 Published:2007-01-24
  • Contact: XU Zhong-hua

PDF (PC)

747

Abstract: Objective: To investigate the changes of human detrusor transforming growth factor -β(TGF-β) after bladder outlet obstruction (BOO) induced by benign prostatic hyperplasia (BPH). Methods： Obstructive detrusor stability was found in 33 patients and obstructive detrusor overactivity in 21 patients; and bladder tumor in 15 men (control) who were operated on in the same period. TGF-β was measured by immunohistochemical staining. Results： The TGF-βlevels of the obstructive groups were much higher than those in the control group. There were significant differences among the three groups (P<0.01). Conclusion： The TGF-β level is significantly higher after BOO, which might be correlated with denervation supersensitivity and detrusor overactivity.

Key words: Prostatic hyperplasia, Transforming growth factor bata, Detrusor overactivity

CLC Number: 

  • R711.32
[1] ZHENG Gui-xi, WANG Chuan-xin, ZHANG Xin, LI Wei, DU Lu-tao, LI Juan, LIU Hui. Screening and biological characteristics study of human
single chain Fv antibody against prostatic cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(11): 34-38.
[2] ZHONG Hao, LI Bo, WANG Jin, WEI Chun-xiao, JIN Xun-bo. Effect of straight light beam greenlight PVP for the
treatment of benign prostatic hyperplasia [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(11): 88-.
[3] ZHAO Zuo-hui1, SUN Bo1, WANG Jian-jun1, JIANG Ting-qi1, LI Shun-lai1, WANG Wan-li1, MA Tian-jia2. Effect of hemocoagulase on coagulation and fibrinolytic function in the  peri-operative period of BPH patients with PKRP [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(1): 90-93.
[4] WANG Jian-jun, ZHAO Zuo-hui, SUN Bo, JIANG Ting-qi, LI Shun-lai, WANG Wan-li, DONG Gang, WANG Xin-sheng. State of prethrombosis in the perioperative period of PKRP [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(12): 100-103.
[5] WANG Jianjun1, ZHAO Zuohui1, SUN Bo1, PAN Yuzhen1, LI Shunlai1,
WANG Wanli1,　DONG Gang1, MA Tianjia2
. The blood glucose, sodium, chloride, potassium and hematocrit of PKRP in the perioperative period [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2009, 47(01): 95-97.
[6] WANG Rong-hai,YANG Ming-shan. Expressions of androgen receptor in benign prostatic hyperplasia with High PSA value and prostatic cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2008, 46(5): 506-509.
[7] YAN Lei,LIU Ben,XU Zhong-hua,ZHOU Zun-lin,CAI Song-liang. hanges of basic fibroblast growth factor in bladder smooth muscle in patients [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2006, 44(10): 1011-1013.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd