JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

• Articles • Previous Articles     Next Articles

Association between polymorphisms of killer cell immunogloblinlikereceptor gene and ankylosing spondylitis

  

  1. 1. Medical Research Centre, Shandong Provincial Hospital, Shandong University, Jinan 250021, Shandong, China; 2. Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan 250062, Shandong, Chin
  • Received:2006-02-19 Revised:1900-01-01 Published:2006-11-24

Abstract: To investigate whether the polymorphisms of killer cell immunoglublinlike receptor(KIR) gene has relation with the ankylosing spondylitis (AS). Methods： Polymerase chain reactionsequencespecific primers (PCRSSP) method was employed for genotyping KIRs from genomic DNA of 86 AS patients and 412 healthy donors. Results： Gene frequencies of KIR3DS1（P=0.044）, KIR2DL2（P=0） and KIR2DL5（P=0.01）were statistically significant higher in the patient group than in the control group. Moreover, the percentage of patients carrying two or more activating KIRs was higher than that of controls. The frequencies of the other KIR loci subjected to assay in this work showed no significant difference in patients and controls. Conclusion： The data from this study suggest that the imbalance of KIR genes may have an association with a genetic predisposition to ankylosing spondylitis.

Key words: Killer cells, Receptors, Spondylitis ankylosing, Genotyping, Immunogloblinlike

[1] ZHANG Dao-Lai, SUN Tao, XIE Shan-Shan, WANG Yu-Zhuo, ZHAO Ling, FENG Yu-Xin, XIN Hua. Developmental expression of NMDAR1 subunit on cultured cerebral cortical neurons of fetal rats in vitro [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 28-32.
[2] ZHAO Lu, JIAO Jun, ZHANG Teng, JIAO Xinlin, CUI Baoxia. Expression of LXRα in ovarian carcinoma and effects of T0901317 on SKOV3 cell line [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(1): 49-53.
[3] GUAN Jingyun, YANG Yang, QIU Chunhong, LI Xiangzhi. Role of histone acetyltransferase MOF in the pathogenesis of multiple sclerosis [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(2): 27-32.
[4] DONG Xiaojing, LI Jing, ZHAO Lei, QI Mei, SUN Zeyu, WANG Hong, ZHAO Weiming. Effect of natural killer cells on the production of interleukin-22 and disease process during Chlamydia muridarum lung infection [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(11): 19-23.
[5] ZHANG Mingming, AN Yonghui, HAN Caili, ZHANG Yingqi, MA Ming, LI Na, ZOU Changpeng. Clinical efficacy of combined cellular immunotherapy and photodynamic therapy for advanced esophageal cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(1): 38-41.
[6] WANG Fuying1, LIU Xiaomeng2, DONG Qingyu2, LIANG Cuige2, DU Wenhua2, WANG Yueli2, LI Wenxia2, GAO Guanqi2. Dynamic changes of serum TRAb concentration after 131I treatment of Graves’ disease and its association with early hypothyroidism [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(6): 55-57.
[7] ZHANG Qian1，2, QIAN Fen-hong3, ZHOU Lin-fu4, WEI Guo-zhen1,BAI Jian-ling5, YIN Kai-sheng4, SHI Yi2. Association of TLR7/8 polymorphisms with risk and severity of asthma in Han population of Jiangsu province of China [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(2): 93-98.
[8] JI En-fei1， LIU Xue-wen2. Protective effects and mechanism of p38MAPK signaling pathway inhibitors on NMDA-induced primary cultured cortical neurons injury in vitro [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(11): 10-15.
[9] LIU Xue-wen1, ZHU Jin-li2, TIAN Bu-xian1, LI Xi-dong1, CAI Ai-min1, XING Rui-xian1, ZHANG Xue-jie1, LI Qiu-shi1. Activations of P-p38MAPK and caspase-3 in NMDA-induced cultured
cortical neurons in vitro and the protective effect of SB203580 [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(6): 51-56.
[10] YU Xiao1, YU Pi-xian2, ZHAO Dan-dan3, LIU Fu-chen3, YAN Chuan-zhu3. A3 adenosine receptor expression in idopathic
inflammatory myopathies [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(6): 105-.
[11] LIU Hai-rong1， YU Jin-ming2， LI Yan1， LIANG Jing1， LIU Xiao-lin1. Study of the relationship between ER， PR， C-erB-2 and
bone metastasis of  lung adenocacinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(4): 91-.
[12] BIAN Xiao-kun1， SI Yuan-quan1， LU Nan3， LI Ying-Jie1， JIA Yan-fei2， ZHANG Yi1. Expression and clinical significance of immunoglobulin-like transcript 2 in gastric cancer cells [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(1): 117-.
[13] LIU Yong1, GU Ying-Hui1, PENG Yan1, ZHOU Guo-ping2, ZHOU Deng-ming2, MIAO Bei3, HOU Xiao-yu1. Neur-oprotection of Egb761 against glutamate excitotoxicity through inhibiting  glutamate receptors in cultured rat hippocampal neurons [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(6): 15-19.
[14] YIN Xian-ming1, DONG Bai-hua1, ZHANG Yun2, SU Shi-li1, DONG Zhao-gang2, QU Xun2. Expression of integrin αvβ3 on NK cells of women with  early pregnancy or missed abortion [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(6): 140-.
[15] WANG He-li1, SUN Xue-mei2, SUN Zheng-yun1, WANG Na1, LIN Xia1. Changes of CD3+, CD4+ and CD8+ T cells and natural killer cells in neonates born to gestational diabetes mellitus mothers and  their relationship with blood glucose [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(4): 4-.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd