Abstract: Objective To review the early treatment and diagnositic modalities of 3 patients with Brucella periprosthetic joint infection and to review the relevant literature. Method The clinical data of the three patients with brucella periprosthetic joint infection were analysed, and the relevant literature was reviewed. Results The diagnosis of these three patients was confirmed by joint fluid or tissue culture. The serological tests of these patients were also positive. One patient was diagnosed with mixed infection and the pathogenic bacteria of the infection was Finegoldia magna. Symptoms were resolved after antibiotics alone, debridement antibiotics and implant retention(DAIR)or two-stage revision arthroplasty. Conclusion Cultures of synovial fluid and intraoperative periprosthetic tissue represent the routine method for diagnosing periprosthetic joint infection caused by brucella. Brucella serology test is helpful in the diagnosis. Antibiotics alone or debridement antibiotics and implant retention(DAIR)has been effective and should be considered first in patients without loosening of brucella-induced periprosthetic joint infection. Two-stage revision arthroplasty should be considered for patients in whom the pathogenic bacteria cannot be identified piror to surgery.

Key words: Arthroplasty, Periprosthetic joint infection, Brucella, Total knee arthroplasty, Total hip arthroplasty