JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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HAN Yong-tao,HUANG Gui-hua2,XI Yan-wei,ZHU Rui-hong   

  1. 1. Department of Pharmaceutics, Qilu Hospitial of Shandong University;2. Department of Pharmaceutics, School of Pharmacy, Shandong University;
  • Received:2006-01-10 Revised:1900-01-01 Online:2006-08-24 Published:2006-08-24
  • Contact: HAN Yong-tao

Abstract: To prepare microsphere containing Azithromycin（AZM） with polylactic acid, and investigate the characteristics of AZM microsphere (AZMMS)in vitro release. Methods: AZMMS was prepared by emulsion solutionevaporation, and its morphology and particle size were examined by light electron microscope.Entrapment ratio, structural properties, quality and the release of AZM in vitro were studied. Results: The AZMMS assumed spherical shape. Its distribution of particle diameter was even with an average particle size of(20.8±0.5)nm. The entrapment ratio was(68.3±1.29)%. The release of AZMMS in vitro conformed to Higuchi Equation.The formation of a new material phase was testified by differential scanning calorimetry(DSC). Conclusion: AZMMS is a good lungtargeting drug release system.

Key words: Azithromycin, Polylactic acid, Microsphere

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