Journal of Shandong University (Health Sciences) ›› 2023, Vol. 61 ›› Issue (12): 36-43.doi: 10.6040/j.issn.1671-7554.0.2023.0389

• The innovation and challenge of artificial intelligence in medical imaging-Clinical Research • Previous Articles    

Identification of carotid high-risk plaques by non-alcoholic fatty liver disease based on CTA

XU Tianqi1,3, CHANG Na2, ZHANG Shuai3, LI Sha1,3, JIAO Bingxuan1,3, YU Xinxin1,3, WANG Ximing1,3   

  1. 1. Cheeloo College of Shandong University, Jinan 250012, Shandong, China;
    2. Department of Medical Technology, Jinan Vocational College of Nursing, Jinan 250102, Shandong, China;
    3. Department of Medical Radiology, Shandong Provincial Hospital, Jinan 250021, Shandong, China
  • Published:2024-01-11

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Abstract: Objective To investigate the correlation between non-alcoholic fatty liver disease(NAFLD)and carotid artery high-risk plaques by computed tomographic angiography(CTA). Methods A total of 203 patients(119 males and 84 females)aged 61.4±12.5 years who underwent carotid CTA for suspected cardiovascular diseases during Jan. and Oct. 2022 were involved. NAFLD was defined as hepatic steatosis without clinical liver disease, cirrhosis or alcohol abuse as demonstrated by non-enhanced CT(hepatosplenic CT value ratio <1). The patients were divided into NAFLD(case group)and non-NAFLD group(control group)according to the abdominal CT findings. The general clinical data, characteristics of high-risk plaques(positive remodeling, ulceration, lipid plaques, "napkin ring" sign), nature of plaques, and degree of carotid stenosis were compared between the two groups. The correlation between NAFLD and presence of high-risk plaques in carotid arteries was analyzed with binary Logistic regression. Results Patients in the NAFLD group had a significantly higher prevalence of diabetes mellitus(P=0.047), levels of alanine aminotransferase(P=0.015), glutamyl transpeptidase(P=0.029), triglycerides(P=0.004), and high-density lipoprotein(P<0.001)than the non-NAFLD group; the presence of high-risk plaques(P=0.001), non-calcified plaques(P=0.015)and incidence of partially calcified plaques(P=0.008)in the common carotid artery and extracranial segment of the internal carotid artery, and non-calcified plaques(P=0.022)and incidence of partially calcified plaques(P=0.002)in the intracranial segment of the internal carotid artery were also higher than the non-NAFLD group. In multivariate Logistic analysis, NAFLD remained independently associated with high-risk plaques after adjusments of age, sex, history of diabetes, hypertension, GGT, uric acid, total carotid artery, calcified plaques in the internal carotid artery, noncalcified plaques, and partially calcified plaques and degree of stenosis(OR: 4.85; 95%CI: 1.77-13.28; P=0.002). Conclusion NAFLD is independently associated with carotid high-risk plaques detected by CTA.

Key words: Non-alcoholic fatty liver disease, Carotid plaque, High-risk plaque, Carotid atherosclerosis, Carotid CT angiography

CLC Number: 

  • R445.3
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