JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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GAO Yan-hui, LI Bao-iu,GAN Yi-u, DONG Xin, CHENG Xiu-min, ZHAO Yan-biao   

  1. 1. School of Pharmaceutics, Shandong University, Jinan 250012, Shandong, China;2. Institute of Toxicology, Shandong University, Jinan 250012, Shandong, China;
  • Received:2006-02-10 Revised:1900-01-01 Online:2006-08-24 Published:2006-08-24
  • Contact: GAO Yan-hui

Abstract: To study the tissue distribution and antitumor effect of a new preparation paclitaxelloaded nanoparticles (PCTN) injection in tumorbearing mice. Methods: Kunming breed mice were subcutaneously inoculated hepatoma H22 cell to the armpit of forelimb, and then injected PCTN and Toxal injection (PCT) into tail vein. The concentration of paclitaxel in tissue was determined by liquid chromatographytandem mass spectrometry. Results: Paclitaxel was mainly found in pancreas, ovary and spleen and it was higher in PCTN than in PCT (P<0.05), and PCTN on the concentration of 2.5?mg/kg had the most efficacious inhibiting effect on tumor, whereas there was no obvious difference between PCTN and PCT in other tissues of tumorbearing mice (P>0.05). Conclusions: Both PCTN and PCT have obvious inhibiting effect on tumor, and the targeting efficiency of PCTN in

Key words: Paclitaxel, Nanoparticles, Liquid chromatographytandem mass spectrometry, Tissue distribution

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