Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (12): 58-62.doi: 10.6040/j.issn.1671-7554.0.2022.0386

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Clinical characteristics of bronchiolitis obliterans syndrome after allogeneichematopoietic stem cell transplantation in 9 children

LIANG Ziting1*, XU Changjuan1*, ZENG Rong1, ZHANG Jintao1, ZENG Qingshi2, DONG Liang1,3   

  1. 1. Department of Respiratory, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, Shandong, China;
    2. Department of Radiology, The First Affiliated Hospital of Shandong First Medical University &
    Shandong Provincial Qianfoshan Hospital, Jinan 250014, Shandong, China;
    3. Department of Respiratory, The First Affiliated Hospital of Shandong First Medical University &
    Shandong Provincial Qianfoshan Hospital, Shandong Institute of Respiratory, Jinan 250014, Shandong, China
  • Published:2022-12-01

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Abstract: Objective To analyze the clinical characteristics of bronchiolitis obliterans syndrome(BOS)in children who had received allogeneic hematopoietic stem cell transplantation(allo-HSCT). Methods The clinical data of 9 children with BOS after allo-HSCT treated in Shandong Provincial Qianfoshan Hospital during Aug. 2014 and Mar. 2021 were retrospectively analyzed, including the clinical characteristics, chest imaging features, pulmonary function, diagnosis and treatment. Results The onset of BOS after allo-HSCT was(9.3±4.4)months. Cough and wheezing were the main clinical features. The main manifestations of BOS in the high resolution CT(HRCT)were bronchiectasis, bronchial wall thickening and mosaic sign. Pulmonary function was mainly characterized with obstructive ventilation dysfunction and decreased diffusion function. The rnain treatment were immunosuppressive therapy and corticosteroids. All 9 children improved after treatment. Conclusion BOS is a pulmonary rejection manifestation in children after allo-HSCT. There are no specific clinical manifestations, pulmonary function tests and HRCT findings. Children undergoing transplantation need regular lung function examinations for early diagnosis and treatment.

Key words: Allogeneic hematopoietic stem cell transplantation, Children, Bronchiolitis obliterans syndrome, Clinical features, Diagnosis

CLC Number: 

  • R562.21
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