Journal of Shandong University (Health Sciences) ›› 2020, Vol. 58 ›› Issue (6): 60-64.doi: 10.6040/j.issn.1671-7554.0.2020.109

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Effect of cetrorelix on early moderate and severe ovarian hyperstimulation syndrome

HA Lingxia1,2, LI Weixia1,2, WU Yangyang1,2, YIN Ting1,2, LI Yufeng1,2   

  1. 1.Center for Reproductive Medicine, General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia, China;
    2. Key Laboratory of Fertility Preservation and Maintenance, Ministry of Education, Ningxia Medical University, Yinchuan 750004, Ningxia, China
  • Published:2022-09-27

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Abstract: Objective To assess the effectiveness of cetrorelix on preventing early moderate and severe ovarian hyperstimulation syndrome(OHSS)in high-risk women. Methods A total of 263 patients with high-risk OHSS undergoing cryopreservation of all embryos were randomly divided into two groups: the control group(n=148)received symptomatic treatment including hydroxyethyl starch, metformin, aspirin, and glucocorticoid administration on day of oocyte retrieval. The cetrorelix group(n=115), in addition to symptomatic treatment, started 0.25 mg of cetrorelix daily on day of oocyte retrieval for 3 or 5 days. On day 3 and day 5 post-oocyte retrieval(POR), serum estradiol(E2)levels, hematocrit values, white blood cell(WBC)count, liver markers and coagulation/fibrinolysis parameters were detected, and maximal ovarian diameter(MOD)and ascites volume were assessed by ultrasound scanning. The incidence and severity of early moderate and severe OHSS were evaluated. Results Compared with the control group, E2 level were significantly lower in the cetrorelix group on day 3 and day 5 POR(P<0.05), and the percent of elevated WBC and fibrinogen were significantly lower in the cetrorelix group on day 5 POR(P<0.05). The incidence of moderate and severe OHSS, frequency of aspiration of the ascitic fluid and hospitalization rate was significantly lower in the cetrorelix group(P<0.05). Conclusion Combined with cryopreservation of all embryos, cetrorelix decreases serum E2 levels, improves coagulate functions, and effectively reduces the incidence of early moderate and severe OHSS in high-risk women.

Key words: Cetrorelix, Estradiol, Moderate and severe, Ovarian hyperstimulation syndrome

CLC Number: 

  • R711.6
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