Journal of Shandong University (Health Sciences) ›› 2019, Vol. 57 ›› Issue (2): 44-51.doi: 10.6040/j.issn.1671-7554.0.2018.1490

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Effects of different doses of menopause hormone therapies in perimenopausal women

XU Wenxian1*, WANG Quanmei2*, MA Linjuan1, HUANG Yizhou1, QI Tongyun1, FU Dongxia1, SONG Yang1, LAN Yibing1, LI Chunming1, CHEN Peiqiong1, YING Qian3, ZHOU Jianhong1   

  1. 1. Department of Gynecology, Womens Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, Zhejiang, China;
    2. Department of Obstetrics and Gynecology, The First People’s Hospital of Tonglu, Tonglu 311500, Zhejiang, China;
    3. Journal of Chinese Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, Zhejiang, China
  • Published:2022-09-27

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Abstract: Objective To compare the effectiveness and safety of different doses of menopause hormone therapies(MHT)in the remission of menopausal symptoms. Methods The clinical data of 450 perimenopausal women who received MHT during 2012 and 2017 were retrospectively analyzed. According to the doses of estradiol valerate, the pa- 山 东 大 学 学 报 (医 学 版)57卷2期 -徐文娴,等.围绝经期应用不同剂量绝经激素治疗的临床观察 \=-tients were divided into 3 groups:group A(standard dose, n=62), group B(low dose, n=322)and group C(ultralow dose, n=66). One treatment cycle lasted for 28 days, during which the continuous sequential regimen was adopted. Before and after treatment, modified Kupperman menopausal index(mKMI)were surveyed, reproductive hormones and glucolipid metabolic indexes were detected, and breast ultrasound was performed. Results Before treatment, there were no significant differences in the general characters and clinical indexes among the 3 groups(all P>0.05). Compared to baseline, the mKMI scores and follicle stimulating hormone(FSH)level significantly decreased, while estradiol level significantly increased after 1, 3 and 6 treatment cycles in all 3 groups(all P<0.001). After 6 treatment cycles, the level of high-density lipoprotein cholesterol(HDL-C)markedly increased in groups B and C, and the levels of low-density lipoprotein cholesterol(LDL-C), fasting blood glucose and fasting insulin significantly decreased in groups A and B(all P<0.01). There were no statistical changes in the thickness of mammary glands, size of mammary nodules and dilatation of ducts in the 3 groups before and after treatment(all P>0.05). Breast distention occurred in 7 cases(11.3%)in group A, 14 cases in group B(4.3%)and 1 case in group C(1.5%), the difference in incidence between groups A and C was significant(P<0.05). Conclusion The standard, low and ultra-low doses of MHT can effectively relieve the menopausal symptoms in perimenopausal women. The standard and low dose are superior to the ultra-low dose in improving glucolipid metabolism. The ultra-low dose has advantages in tolerance. The different doses of MHT has no effects on the mammary glands during the observation period.

Key words: Menopause hormone therapy, Perimenopause period, Low dose, Ultra-low dose, Menopausal symptoms

CLC Number: 

  • R711
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