Abstract: Objective To evaluate the efficacy and safety of perioperative intravenous iron sucrose therapy in elderly patients with femoral intertrochanteric fracture. Methods A total of 81 patients with femoral intertrochanteric fracture(≥65 years)treated with proximal femoral nail anti-rotation(PFNA)were divided into two groups: treatment group(n=41), and control group(n=40). The treatment group received 200mg iron sucrose onceadayfor3 consecutive days after admission, while the control group did not receive any iron treatment. The blood transfusion rate, hemoglobin(HB),serum ferritin, complication rate and healing were compared between the two groups. Results The transfusion rate in the treatment group and control group was 48.8% vs 52.5%, with no significant difference between the two groups(P>0.05). The HB of 7, 30, 90 days postoperatively in the treatment group and control group were(95.2±10.5)vs(90.1±12.1),(118.9±13.6)vs(109.8±12.8), and(125.5±14.9)vs(118.6±12.3)g/L. There were significant differences between the two groups(P<0.05). The serum ferritin in both groups was higher than normal before surgery, and markedly increased after operation, especially in the treatment group. There were no significant differences in complication rate and fracture healing between the two groups(P>0.05). Conclusion Perioperative intravenous iron sucrose can increase HB and improve anemia in elderly patients with femoral intertrochanteric fracture, but it cannot reduce transfusion rate.

Key words: Femoral intertrochanteric fracture, Internal fixation, Iron sucrose, Transfusion