卵巢肿瘤组织中抑癌基因ARHI的表达及组蛋白去乙酰化酶抑制剂对其的影响

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

• Articles • Previous Articles Next Articles

ZHANG Lan¹,LIU Pei-shu²,WANG Xiu-ying²,XIN Gang²

1. Department of Gynecology and Obstetrics, Qilu Hospital of Shandong University,Jinan 250012, Shandong, China; 2.Department of Gynecology and Obstetrics, Ningyang People′s Hospital,Tai′an 271400, Shandong, China;

Received:2005-10-14 Revised:1900-01-01 Online:2006-12-24 Published:2006-12-24
Contact: ZHANF Lan

Abstract

Abstract: To investigate the expression of ARHI in ovarian tumor and the effects of histone deacetylase inhibitors(HDACIs) on the growth of ovarian cancer cells and the ARHI expression. Methods: mRNA expression of ARHI gene was evaluated in normal ovary and ovarian tumor by RTPCR. And the effects of HDACIs on the expression of the ARHI in four ovrian cancer cells(SKOV3, A2780, COC1, OC3) was detected by RTPCR and MTT. Results: ①ARHI was expressed in all the normal ovarian tissues (100%), but there was a different decline of ARHI gene in ovarian tumor; ②The positive expression of ARHI was correlated with the malignant degree of tumor (P＜0.05) and the clinical staging of ovarian cancer (P＜0.05), but not correlated with the hisgrading parameters of cancer

Key words: Ovarian cancer, ARHI, Trichostatin A, Gene expression

ZHANG Lan,LIU Pei-shu,WANG Xiu-ying,XIN Gang. [J].JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2006, 44(12): 1276-1280.

References

Related Articles 15

[1]	LI Chang, ZHANG Qian, MA Fang, XIE Qi, CHANG Xiaotian. Relationship between PADI2 and genetic susceptibility in various human tumors [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(11): 47-53.
[2]	LU Heng, LIU Yanguo, LI Shuguang, CHEN Xiaokang, TIAN Qi, YI Cuihua, WANG Xiuwen. Regulation of epithelial ovarian carcinoma SKOV-3 cell migration by YKL-40 [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(1): 33-38.
[3]	ZHAO Lu, JIAO Jun, ZHANG Teng, JIAO Xinlin, CUI Baoxia. Expression of LXRα in ovarian carcinoma and effects of T0901317 on SKOV3 cell line [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(1): 49-53.
[4]	LIU Mengmeng, ZHAO Cuifen, KONG Qingyu, CAI Zhifeng, XIA Wei. miR-1/133 participates in the expression of ion channel genes of myocardial cells in myocarditis mice [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(8): 6-11.
[5]	XIAO Junchao, JIANG Wen, NAN Hui, WANG Peirong. A recombinant adenovirus fiber knob protein sensitizes ovarian cancer cells to cetuximab therapy [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(5): 1-5.
[6]	ZHAO Yunxia, SONG Jing, ZHANG Cancan, LIN Xueyan, WEI Wei, TIAN Yongjie. CXXC4 promotes sensitivity to chemotherapy drugs in epithelial ovarian cancer cells [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(3): 24-29.
[7]	XU Zhihong, WU Xiaohua, YAO Tiezhu, WANG Xiaoxiang, DUAN Xiaoyang, SHI Jian. Relationship between mir-99a expression and prognosis of epithelial ovarian cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(3): 77-80.
[8]	CUI Yong, ZHANG Rongxiang, WANG Fuli, WANG Guoying, FENG Jianlin, ZHANG Haixia. Clinical efficacy of BSD2000 deep hyperthermia combined with chemotherapy of TP regimen for advanced ovarian cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(7): 53-57.
[9]	CHEN Jing, LI Chunyan, ZHAO Miaoqing, CUI Jingjing, ZHANG Na, FU Yibing. Expression of EZH2 protein and its role in ovarian epithelial tumor [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(2): 65-70.
[10]	QIU Huihui1， YE Liping1， WEN Youfeng2， LI Dan1， SONG Jia1. Effects of IL-6 on the expressions of bcl-2，cyclinD1 and VEGF in ovarian cancer cells [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(6): 17-21.
[11]	LI Yan, WEI Wei, LV Shuqing, TIAN Yongjie. Effects of PARP-1 on angiogenesis of ovarian cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(4): 97-101.
[12]	ZHANG Wen1, FENG Tingting1, ZHENG Lin1, WANG Hong1, LU Yi2, QI Mei1, YU Xiuping1, TANG Wei1, ZHAO Weiming1. Effects of enhanced expression of RbAp48 mediated by recombinant adenovirus on proliferation and growth of cervical cancer cells [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(4): 13-17.
[13]	ZHANG Miaoci, LI Ping, HA Minwin. Clinical observation of recombinant human endostatin combined with gemcitabine in the treatment of platinum-resistant recurrent ovarian cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(11): 55-59.
[14]	PEI Chang-an, QIN Shi-yong, CHEN Shi-hui, ZHANG Shu-guang. Detection of the Nelin in peripheral blood of patients with varicose veins of lower extremity and its significance [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(9): 64-66.
[15]	ZHANG Yu-ying, ZHANG Liang, PAN Jie. Conditional expression of COX1 gene in 3T3-L1 predipocytes of mice by Tet-On system [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(5): 24-28.