Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (11): 84-92.doi: 10.6040/j.issn.1671-7554.0.2021.0470

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Associations between self-harm behavior and psychosocial-polymorphism in female freshmen

XU Xiaoming1, ZENG Qi2, CAO Jun1, CHEN Xiaorong2, LYU Zhen2, WANG Wo2, AI Ming1, KONG Yiting1, KUANG Li1   

  1. 1.Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China;
    2. Mental Health Center, University-Town Hospital of Chongqing Medical University, Chongqing 401331, China
  • Published:2021-11-11

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Abstract: Objective To explore the factors associated with self-harm behavior in female freshmen by using multi-modal data such as single nucleotide polymorphisms(SNPs)of serotonin receptor gene, social demographic characteristics, and psychological characteristics. Methods iMLDRTM multiplex SNP typing was used to detect 4 SNPs, i. e., rs878567, rs10042486, rs1364043, and rs1423691, in HTR1A gene and 9 SNPs, i. e., rs3125, rs1745837, rs1928042, rs2770296, rs731779, rs6313, rs2070037, rs6311, and rs2070040, in HTR2A gene from 68 female freshmen with self-harm behavior(self-harm group)and 46 healthy controls(control group). The genotypes, alleles, and haplotype frequencies were compared. Additionally, the gene-psychosocial-self-harm interaction was analyzed. Results There were significant differences in the family history of mental illness, structured clinical interview for SCID diagnosis, impulsive personality, aggressive personality, and internet addiction behavior between the self-harm and control group(P<0.05). There was no significant difference in the frequencies of genotypes and alleles of the 13 candidate SNPs between the self-harm and control groups. In the dominant model, the G/T-T/T genotype in rs1364043 locus in self-harm group was 2.19(95%CI=1.01-4.74)times of that in the control group. rs10042486-rs1364043-rs1423691-rs878567 in HTR1A gene and rs2770296-rs731779-rs2070037-rs2070040-rs6313-rs6311 in HTR2A gene showed strong linkage disequilibrium, respectively. There was no significant difference in haplotypes between the self-harm and control groups(P>0.05, adjusted for age, economic level, BMI, chronic somatic disease, family history of mental illness, SCID diagnosis, aggressive personality, impulsive personality, and internet addiction). The interaction between rs6313 and rs6311 loci and impulsive personality showed a significant difference between the control and self-harm groups. Similarly, after the interaction of rs10042486, rs1423691, and rs878567 loci with internet addiction behavior and SCID diagnosis, respectively, significant differences have been shown between the self-harm and control groups(P<0.05). Conclusion The SNPs of the HTR1A and HTR2A gene are related to the self-harm behavior in the female freshmen or play an indirect role through interaction with impulsive personality, internet addiction, or diagnosis of mental disorders.

Key words: Female, University students, Self-harm, Psychosocial factors, Single nucleotide polymorphisms, HTR1A, HTR2A

CLC Number: 

  • C320.57
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