Journal of Shandong University (Health Sciences) ›› 2020, Vol. 58 ›› Issue (12): 97-101.doi: 10.6040/j.issn.1671-7554.0.2020.0470

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Comparison of the efficacy of escitalopram alone and with Qi Yang Yu Xin Dan Fang in the treatment of female depression with sexual dysfunction

WANG Wei, YANG Yongqin, MI Guolin   

  1. Department of Psychiatry, Shandong Mental Health Center, Jinan 250014, Shandong, China
  • Published:2020-12-08

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Abstract: Objective To retrospectively analyze the curative effect of Qi Yang Yu Xin Dan Fang on female depression with sexual dysfunction. Methods A total of 62 female patients with depression and sexual dysfunction were selected, including 31 cases in the control group(escitalopram 20 mg/d)and 31 cases in the experimental group(Qi Yang Yu Xin Dan Fang plus escitalopram 20 mg/d). The Hamilton Depression Scale(HAMD-17), Hamilton Anxiety Scale(HAMA-14), sexual function index(FSFI), Treatment Emergent Symptom Scale(TESS)and prolactin results were collected at baseline and at the end of the 2nd, 4th and 8th week after administration. Results Analysis showed that HAMD scores, HAMA scores, FSFI scores and PRL indexes had statistical significance in group effect, time effect and interaction effect(P<0.05). At the end of the 8th week, the total effective rate of antidepression(87% vs 62%, P<0.05)and sexual dysfunction(65% vs 47%, P<0.05)were higher in the experimental group than in the control group; there was no significant difference in the incidence of adverse reactions between the two groups(16.1% vs 19.4%, P>0.05). Conclusion Escitalopram combined with Qi Yang Yu Xin Dan Fang can effectively improve the symptoms of depression and anxiety, reduce prolactin level and improve sexual function in female patients with depression and sexual dysfunction.

Key words: Qi Yang Yu Xin Dan, Female, Depression, Sexual dysfunction

CLC Number: 

  • R749.4
[1] 张爱霞, 潘连军, 陈湘玉, 等. 南京地区城区女性性功能障碍的调查[J]. 中华男科学杂志, 2011, 17(6): 488-491.
[2] 沈一峰, 徐筠, 顾牛范. 选择性5-羟色胺再摄取抑制药与性功能的关系[J]. 中国新药与临床杂志, 2002, 21(1): 46-50.
[3] 田贞姬, 殷秀荣. 中国中青年女性性功能调查[J]. 中国男科学杂志, 2006, 20(9): 25-28.
[4] Atlantis E, Sullivan T. Bidirectional association between depression and sexual dysfunction: a systematic review and meta-analysis [J]. J Sex Med, 2012, 9(6): 1497-1507.
[5] Piva I, Lo Monte G, Graziano A, et al. A literature review on the relationship between infertility and sexual dysfunction: does fun end with baby making [J]. Eur J Contracep Repr, 2014, 19(4): 231-237.
[6] 胡建. 重视新型抗抑郁药引起的性功能障碍[J]. 中华精神科杂志, 2011, 44(1): 51-52.
[7] 元·朱震亨. 丹溪心法[M]. 北京: 中国中医药出版社, 2008: 96-98.
[8] 李志庸·张景岳医学全书[M]. 北京: 中国中医药出版社, 2002: 1101-1104.
[9] 范肖冬, 汪向东, 于欣, 等. ICD-10精神与行为障碍分类[M]. 北京: 人民卫生出版社, 2004: 97-103.
[10] Hatzinouratidis K, Hatzichristou D. Sexual dysfunctions: classifications and definitions [J]. J Sex Med, 2007, 4(1): 241-250. doi: 10.1111/j.1743-6109.2007.00409.x.
[11] 汪向东, 王希林, 马弘. 心理卫生评定量表手册[M]. 北京: 人民卫生出版社, 1993: 220-223.
[12] 汪向东, 王希林, 马弘. 心理卫生评定量表手册[M]. 北京: 人民卫生出版社, 1993: 253-255.
[13] Xiaoguang Sun, Chunying Li, Lina Jin, et al. Development and validation of Chinese version of female sexual function index in a Chinese population-a pilot study [J]. J Sex Med, 2011, 8(4): 1101-1111.
[14] 清·陈士铎. 辨证录[M]. 北京: 中国中医药出版社, 2008: 256.
[15] 鹿子龙, 付振涛, 杜恩情, 等. 2018年山东省成人自报健康预期寿命测算研究[J]. 山东大学学报(医学版), 2020, 58(9): 83-88. LU Zilong, FU Zhentao, DU Enqing, et al. A study on self-reported health-adjusted life expectancy of adults in Shandong Province,2018[J]. Journal of Shandong University(Health Sciences), 2020, 58(9): 83-88.
[16] Khazaie H, Rezaie L, Rezaei PN, et al. Antidepressant-induced sexual dysfunction during treatment with fluoxetine, sertraline and trazodone; a randomized controlled trial [J]. Gen Hosp Psychiatry, 2015, 37(1): 40-45.
[17] 樊安彤, 田庆, 李欣阳, 等. 女性不孕症患者心理健康状况及其影响因素分析[J]. 山东大学学报(医学版), 2020, 58(1): 110-114. FAN Antong TIAN Qing, LI Xinyang, et al. Analysis of mental health status and influencing factors of female infertility patients[J]. Journal of Shandong University(Health Sciences), 2020, 58(1): 110-114.
[18] Clayton AH, EI HS, Luonakhamhe JP, et al. Sexual dysfunction associated with major depeessive disorder and antidepressant treatment [J]. Expert Opin Drug Saf, 2014, 13(10): 1361-1374.
[19] 王玮. 正念训练对老年抑郁障碍患者的干预效果[J]. 慢性病学杂志, 2020, 21(6): 835-839. WANG Wei. Effect of mindfulness meditation on depression symptoms and sleep quality in elderly depression patients[J]. Chronic Pathematology Journal, 2020, 21(6): 835-839.
[20] Hiranyatheb T, Nakawiro D, Wongpakaran T, et al. The impact of residual symptoms on relapse and quality of life among Thai depressive patients [J]. Neuropsychiatr Dis Treat, 2016,(12): 3175-3181.
[21] 王玮, 陆艺, 陈建平, 等. 抑郁障碍患者筛查及1年随访研究[J]. 中国健康心理学杂志, 2020, 28(6): 824-827. WANG Wei, LU yi, CHEN Jianping, et al. Biphasic screening and 1-year follow-up study of patients with depression[J]. China Journal of Health Psychology, 2020, 28(6): 824-827.
[22] 刘帮彬, 张丽, 汪露, 等. 光照疗法对非季节性抑郁症疗效的随访对照试验系统评价和Meta分析[J]. 中华精神科杂志, 2017, 50(3): 214-221. LIU Bangshan, ZHANG Li, WANG Lu, et al. Eficacy of bright light therapy for nonseasonal major depressive disorder:ameta—analysisof random ized controlled trials[J]. Chinese Journal of Psychiatry, 2017, 50(3):214-221.
[23] Melmed S, Casssanueva FF, Hoffman AR, et al. Diagnosis and treatment of hyperprolactinemia: an endocrine society clinical practice guideline [J]. Clin Endocrinol Metab, 2011, 96(2): 273-288.
[24] 汪天宇, 李英辉, 李磊, 等. 艾司西酞普兰治疗中国抑郁症患者有效性和安全性的Meta分析[J]. 中国临床药理学与治疗学, 2015, 20(9): 1020-1025. WANG Tianyu, LI Yinghui, LI Lei, et al. Eficacy and safety of escitalopram in the treatment of major depressive disorder in Chinesepatients:a meta-analysis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2015, 20(9):1020-1025.
[25] 高作慧, 严峻. 男性抑郁症患者药物治疗前后性功能变化的临床研究[J]. 中国性科学, 2014, 23(10): 20-23. GAO Zuohui, YAN Jun. Changesin the sexualn function of male patients with depression before and after treatment[J]. The Chinese Journal of Human Sexuality, 2014, 23(10):20-23.
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