Journal of Shandong University (Health Sciences) ›› 2020, Vol. 58 ›› Issue (12): 97-101.doi: 10.6040/j.issn.1671-7554.0.2020.0470

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Comparison of the efficacy of escitalopram alone and with Qi Yang Yu Xin Dan Fang in the treatment of female depression with sexual dysfunction

WANG Wei, YANG Yongqin, MI Guolin   

  1. Department of Psychiatry, Shandong Mental Health Center, Jinan 250014, Shandong, China
  • Published:2020-12-08

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Abstract: Objective To retrospectively analyze the curative effect of Qi Yang Yu Xin Dan Fang on female depression with sexual dysfunction. Methods A total of 62 female patients with depression and sexual dysfunction were selected, including 31 cases in the control group(escitalopram 20 mg/d)and 31 cases in the experimental group(Qi Yang Yu Xin Dan Fang plus escitalopram 20 mg/d). The Hamilton Depression Scale(HAMD-17), Hamilton Anxiety Scale(HAMA-14), sexual function index(FSFI), Treatment Emergent Symptom Scale(TESS)and prolactin results were collected at baseline and at the end of the 2nd, 4th and 8th week after administration. Results Analysis showed that HAMD scores, HAMA scores, FSFI scores and PRL indexes had statistical significance in group effect, time effect and interaction effect(P<0.05). At the end of the 8th week, the total effective rate of antidepression(87% vs 62%, P<0.05)and sexual dysfunction(65% vs 47%, P<0.05)were higher in the experimental group than in the control group; there was no significant difference in the incidence of adverse reactions between the two groups(16.1% vs 19.4%, P>0.05). Conclusion Escitalopram combined with Qi Yang Yu Xin Dan Fang can effectively improve the symptoms of depression and anxiety, reduce prolactin level and improve sexual function in female patients with depression and sexual dysfunction.

Key words: Qi Yang Yu Xin Dan, Female, Depression, Sexual dysfunction

CLC Number: 

  • R749.4
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