JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2017, Vol. 55 ›› Issue (10): 14-20.doi: 10.6040/j.issn.1671-7554.0.2017.320

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Evolution of diagnostic criteria for Alzheimers disease: from clinical diagnosis to pathophysiological diagnosis

TANG Yi   

  1. Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
  • Received:2017-04-12 Online:2017-10-10 Published:2017-10-10

Abstract: Alzheimers disease(AD)is the leading cause of dementia and the most prevalent neurodegenerative disease in the elderly. The first diagnostic criteria was developed by the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimers Disease and Related Disorders Association Work Group in 1984. With the further understanding of pathophysiological mechanism underlying AD, two new sets of research criteria for Alzheimers 山 东 大 学 学 报 (医 学 版)55卷10期 -唐毅.阿尔茨海默病诊断标准:从临床诊断到病理生理诊断 \=-disease were proposed: those published by an International Working Group in 2007, which was updated in 2014, and the recommendations published by the National Institute on Aging and the Alzheimers Association(NIA-AA)in 2011. A comparison of the criteria is needed for clinical practice and research purpose.

Key words: Alzheimers disease, Diagnostic criteria, Biomarker, Preclinical AD

CLC Number: 

  • R741.04
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