JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (11): 65-67.doi: 10.6040/j.issn.1671-7554.0.2014.336

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Evaluation of ALS assay (TB-SA antibody) in diagnosis of tuberculous pleurisy

JIAO Jin, WANG Maoshui, WU Yanhua, WANG Xinfeng   

  1. Department of Laboratary Medicine, Shandong Provincial Chest Hospital, Jinan 250013, Shandong, China
  • Received:2014-05-22 Published:2014-11-10

Abstract: Objective To investigate the diagnostic value of the ALS assay (TB-SA antibody) in the tuberculous pleurisy. Methods 55 patients diagnosed as tuberculous pleurisy (TPE group) and 45 healthy persons (healthy group) were enrolled. The levels of TB-SA antibody from lymphocyte secretion were detected by ELISA assay. Mann-Whitney U test was used to compare the levels of TB-SA antibody between the two groups. Receiver operating characteristic (ROC) analysis was performed to analyze the sensitivity of ALS assay (TB-SA antibody) in diagnosis of tuberculous pleurisy. Results The mean concetration of TB-SA antibody from lymphocyte secretion in TPE group was significantly higher than that in healthy group (P<0.01). The area under the curve, best cutoff point, sensitivity, specificity, positive likehood ratio and negtive likehood ratio of the ALS assay (TB-SA) were 0.900 (95%CI: 0.824-0.951), 0.04, 77.8%, 92.7%, 10.69 and 0.24, respectively. Conclusion ALS (TB-SA antibody) assay performs well in the diagnosis of tuberculous pleurisy.

Key words: ALS assay, Tuberculous pleurisy, TB-SA antibody, Receiver operating characteristic curve

CLC Number: 

  • R521.7
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